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Neovascular glaucoma

Part of Glaucoma

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for neovascular glaucoma

6 trials tracked for neovascular glaucoma: 3 in phase 3 or 4 and 2 with published results. The most-cited published study has 15 citations.

6Trials tracked
3Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 3 3 Phase 2 1 Other / NA 2
  1. Phase 3 Study to Learn How the Drug Aflibercept Works in in Japanese Patients With Increased Eye Pressure That is Caused by New Blood Vessels Growing in the Eye (Neovascular Glaucoma or NVG). Safety of the Drug and Patients' Tolerability of the Drug Injection is Also Studied Completed · 15 cited
  2. Phase 3 Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients Completed · 15 cited
  3. Phase 3 An Open-label Extended Clinical Protocol of Ranibizumab to Evaluate Safety and Efficacy in Rare VEGF Driven Ocular Diseases. Completed
  4. Phase 2 Ahmed Glaucoma Valve Surgery With Mitomycin-C Completed
  5. N/A Treatment Outcomes of MicroPulse Trans-scleral Cyclophotocoagulation in Uncontrolled Glaucoma Completed
  6. N/A Use of Intravitreal Aflibercept Injection for Neovascular Glaucoma Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Neovascular glaucoma: what the trials found

Aflibercept has been evaluated in Phase 3 trials for the management of neovascular glaucoma. In one study, Aflibercept administration resulted in a significant reduction in intraocular pressure (IOP) from baseline to week 1 (-8.3; p=0.0004).

In another Phase 3 trial involving Aflibercept, results for IOP change at week 1 were -8.5 and -4.9 (p=0.0644). Regarding the Neovascularization of the Iris (NVI) grade, these trials reported improvement rates of 13% and 70.4% respectively.

Ranibizumab was also evaluated in a Phase 3 trial for this condition.

Recent results — preliminary, needs further review

  • Mitomycin-C was assessed in a Phase 2 trial (not yet corroborated).
  • MicroPulse® P3 Glaucoma Device (MP3) showed Cup-to-disc Ratio (CDR) and OCT-assessed CDR of 0.82 (not yet corroborated).
  • Aflibercept was evaluated in a small study showing specific baseline and week 52 IOP measurements (not yet corroborated).

For the clinician treating this condition

  • Aflibercept is associated with significant reductions in intraocular pressure (IOP) at one week post-treatment.
  • Clinical evidence for Aflibercept shows varying rates of improvement in Neovascularization of the Iris (NVI) grade between different Phase 3 studies.
  • Ranibizumab has been investigated as a treatment option in Phase 3 clinical trials.

AI synthesis of 0 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Glaucoma

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