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Home › Conditions › nervous system diseases

Nervous system diseases

Subtypes of Nervous system diseases

Neurological disorders 11

14 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for nervous system diseases

20 trials tracked for nervous system diseases: 8 in phase 3 or 4 and 5 with published results. The most-cited published study has 460 citations.

20Trials tracked
8Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 3 8 Phase 2 3 Phase 1 1 Other / NA 8
  1. Phase 3 Phase 3 Study of Ataluren in Participants With Nonsense Mutation Duchenne Muscular Dystrophy (nmDMD) Completed · 460 cited
  2. Phase 3 Safety and Tolerability Study of Flexible Dosing of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type Completed · 12 cited
  3. Phase 3 Topical Vancomycin for Neurosurgery Wound Prophylaxis Completed · 9 cited
  4. Phase 3 A Phase 3, 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of 2 Fixed Doses of Brexpiprazole in the Treatment of Alzheimer's Agitation Completed · 2 cited
  5. Phase 3 Long-Term Outcomes of Ataluren in Duchenne Muscular Dystrophy Completed · 1 cited
  6. Phase 3 Open-label Study of Midazolam Hydrochloride Oromucosal Solution (MHOS/SHP615) in Children With Status Epilepticus (Convulsive) in a Healthcare Setting in Japan Completed
Show 14 more trials
  1. Phase 3 Study of Midazolam Hydrochloride Oromucosal Solution (MHOS/SHP615) in Pediatric Patients With Status Epilepticus (Convulsive) in the Community Setting Completed
  2. Phase 3 A Study to Evaluate eFFIcacy and Safety of Sublingual TNX-102 SL Tablet Taken at Bedtime in Patients With fibRoMyalgia Completed
  3. Phase 2 AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS) Completed
  4. Phase 2 Open-label Study to Assess Usability of the Medical Information Device #1 (MIND1) System in Adults With Schizophrenia On Oral Aripiprazole Completed
  5. Phase 2 A Study of CAP-1002 in Ambulatory and Non-Ambulatory Patients With Duchenne Muscular Dystrophy Completed
  6. Phase 1 Safety and Tolerability Study of Aripiprazole IM Depot in Adult Subjects With Schizophrenia Completed
  7. N/A Predictors of Response in Chronic Stroke Completed
  8. N/A Long-term Telerehabilitation for Patients With Stroke Completed
  9. N/A Dietary Supplements for the Treatment of Angelman Syndrome Completed
  10. N/A GORE Flow Reversal System and GORE Embolic Filter Extension Study Completed
  11. N/A Harmony at Home: A Pilot Telehealth Program for Rural ADRD Caregivers Completed
  12. N/A Upper Extremity Function in Multiple Sclerosis Patients With Advanced Disability Treated With Ocrevus Completed
  13. N/A Cost-effectiveness of Forced Aerobic Exercise for Stroke Rehabilitation Completed
  14. N/A Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems Completed

Showing the 20 most-cited and recently-updated of 20 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Nervous system diseases: what the trials found

New evidence indicates that Ataluren showed a statistically significant reduction in 6-Minute Walk Distance (6MWD) at week 72 when analyzed using an Intent-to-Treat (ITT) population 1. However, this same metric did not reach statistical significance in the Modified Intention-to-Treat (mITT) population 1. In a separate study of Ataluren, no significant change was observed in 6MWD at week 48 2.

Regarding agitation management, Brexpiprazole combined with OPC-34712 demonstrated a statistically significant reduction in the Cohen-Mansfield Agitation Inventory (CMAI) total score after 12 weeks of treatment 5, though it did not significantly impact Clinical Global Impression-Severity of Illness (CGI-S) scores related to agitation 5. A different trial using the same combination did not reach statistical significance for CMAI scores 3.

In the management of seizures, SHP615 demonstrated a response rate of 80% in a small cohort 8. In this study, patients showed sustained absence of seizure activity for at least 1, 4, and 6 hours at rates of 68.0%, 36.0%, and 32.0%, respectively 8. A smaller trial reported that no participants required additional anticonvulsant medication for ongoing status epilepticus after administration of SHP615 7.

For fibromyalgia, TNX-102 SL (2.8mg) showed a reduction in both the Fibromyalgia Impact Questionnaire - Revised (FIQR) Symptoms Domain Score and Function Domain Score at week 12 6.

Recent results — preliminary, needs further review

  • Aerobic exercise was evaluated for motor function; results showed mean scores of 2.4 and 2.7 on the Wolf Motor Function Test (WMFT) 13.

For the clinician treating this condition

  • Ataluren shows mixed evidence regarding its impact on 6MWD, with significance only observed in ITT analysis 1.
  • Brexpiprazole combined with OPC-34712 significantly reduces Cohen-Mansfield Agitation Inventory (CMAI) scores in some instances but not all [3, 5].
  • SHP615 demonstrated a high response rate and sustained absence of seizure activity in patients with status epilepticus 8.
  • TNX-102 SL (2.8mg) is associated with improvements in both symptom and function domains for fibromyalgia 6.

AI synthesis of 8 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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Neurology Cohort
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Frontiers Apr 10, 2026
Review examines automated ventricular segmentation from MRI for neurological disease insights
Neurology Sys. Review
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Frontiers Apr 2, 2026