Mode
Text Size
Log in / Sign up

Pre-eclampsia

Part of Pregnancy induced hypertension

7 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Pre-eclampsia

19 trials tracked for Pre-eclampsia: 5 in phase 3 or 4 and 1 with published results. The most-cited published study has 8 citations.

19Trials tracked
5Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 3 Phase 3 2 Phase 2 5 Other / NA 9
  1. Phase 3 Furosemide vs. Placebo for Severe Antepartum Hypertension Completed · 8 cited
  2. Phase 4 The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Completed
  3. Phase 4 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Completed
  4. Phase 4 Optimal Blood Pressure Treatment Thresholds Postpartum Completed
  5. Phase 3 Effectiveness of Higher Aspirin Dosing for Prevention of Preeclampsia in High Risk Obese Gravida Completed
  6. Phase 2 Study of Nicotinamide in Early Onset Preeclampsia Completed
Show 13 more trials
  1. Phase 2 Effect of Vitamin D3 Supplementation in Pregnancy on Risk of Pre-eclampsia Completed
  2. Phase 2 Efficacy Study of Digibind for Treatment of Severe Preeclampsia Completed
  3. Phase 2 Role of ASpirin in Placental and Maternal Endothelial Cell Regulation IN Pre-eclampsia Completed
  4. Phase 2 Assessment of a Syringe Pump to Pre-eclamptic Women in a Low-resource Hospital Completed
  5. N/A Vascular Inflammation and Anti-inflammatory Supplements After Adverse Pregnancy Outcomes Completed
  6. N/A Thoracic Ultrasonography for Pulmonary Edema in Patients With Pre-Eclampsia Completed
  7. N/A Accuracy Assessment of an Automatic Blood Pressure Measurement Device in Pregnant Women Completed
  8. N/A Neonatal Sleep Intervention to Improve Postpartum Hypertension Completed
  9. N/A FACT Biomarker Subgroup Analysis Completed
  10. N/A Acute Exercise Effects in Obese Pregnancy Completed
  11. N/A Pilot Assessment of an Auto Blood Pressure Monitor Completed
  12. N/A Restrictive Fluid Therapy in Severe Preeclampsia Completed
  13. N/A Accuracy Assessment of an Automatic Blood Pressure Measurement Device in Adult Volunteers Completed

Showing the 19 most-cited and recently-updated of 19 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Pre-eclampsia: what the trials found

Newer evidence regarding the use of acetylsalicylic acid (81 mg) is currently being evaluated in clinical trials.

The Sphygmo automatic blood pressure monitor has been validated for accuracy, with high percentages of readings falling within 10 mmHg and 15 mmHg of gold standard sphygmomanometer measurements [16, 17].

Pharmacological interventions such as aspirin (81 mg) have been evaluated in relation to neonatal outcomes; results showed no significant difference in preterm births, low Apgar scores, or intraventricular hemorrhage grades between groups 5.

Furosemide was evaluated for blood pressure management, with recorded systolic and diastolic values at 2 hours post-administration showing no statistically significant differences between study arms 4.

Recent results — preliminary, needs further review

  • Acetylsalicylic Acid (81 mg) is currently undergoing investigation in Phase 2 trials 6.

For the clinician treating this condition

  • The Sphygmo device demonstrates high reliability for blood pressure monitoring, with up to 98% of readings within 15 mmHg of the gold standard 17.
  • Aspirin (81 mg) does not appear to negatively impact neonatal outcomes such as preterm birth or intraventricular hemorrhage based on available data 5.

AI synthesis of 4 cited trials, updated Jun 28, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Questions about Pre-eclampsia

Is there a link between pre-eclampsia history and increased markers of atherosclerosis?

Yes, research shows women with a history of pre-eclampsia have higher markers of subclinical atherosclerosis, including increased carotid artery thickness and impaired blood vessel function.

Full answer →
What does the research say about using Treg-targeting strategies for pre-eclampsia safety?

Research shows Treg-targeting strategies are a new idea for pre-eclampsia, but current studies lack safety data or reported outcomes for pregnant patients.

Full answer →
Does having hidradenitis suppurativa increase the risk of pre-eclampsia or birth defects?

Having hidradenitis suppurativa increases the risk of pre-eclampsia, but current research does not show a clear link to birth defects.

Full answer →
Are there safe treatments for pregnancy complications that target regulatory T cells?

Current research indicates that while regulatory T cells are important for preventing pregnancy complications like pre-eclampsia, there are no safe or approved treatments targeting these cells for use during pregnancy yet.

Full answer →
Can high uric acid levels before 20 weeks predict gestational diabetes or pre-eclampsia?

High uric acid before 20 weeks is linked to higher risk of gestational diabetes and pre-eclampsia, but evidence is limited for predicting pre-eclampsia specifically.

Full answer →
Does having pre-eclampsia in the past increase my risk of heart disease later?

Yes, a history of pre-eclampsia is linked to a higher risk of later heart disease, likely due to early blood vessel damage that can be detected years after pregnancy.

Full answer →
See all 6 questions about Pre-eclampsia →