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Renal failure

Part of Kidney Diseases

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for renal failure

26 trials tracked for renal failure: 12 in phase 3 or 4 and 2 with published results. The most-cited published study has 93 citations.

26Trials tracked
12Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 1 Phase 3 11 Phase 2 5 Other / NA 9
  1. Phase 3 Crossover Study to Compare PK of Once Daily LCP-Tacro Tablets to Generic Tacrolimus Capsules Twice Daily. Completed · 93 cited
  2. Phase 3 Comparison of the Human Acellular Vessel (HAV) With ePTFE Grafts as Conduits for Hemodialysis Completed · 14 cited
  3. Phase 4 Preemptive Treatment With Grazoprevir and Elbasvir for Donor HCV Positive to Recipient HCV Negative Kidney Transplant Completed
  4. Phase 3 A Long-Term Safety Extension Trial of Ferric Citrate in Patients With End-Stage Renal Disease (ESRD) on Dialysis Completed
  5. Phase 3 AURORA: Crestor 10mg Versus Placebo in Subjects With End-stage Renal Disease (ESRD) Completed
  6. Phase 3 Pharmacokinetic Comparison Of All FK-506 Formulations Completed
Show 20 more trials
  1. Phase 3 Heme Iron Polypeptide for Iron Deficiency Anemia in Chronic Renal Failure Completed
  2. Phase 3 Switching Study of Kidney Transplant Patients With Tremor to LCP-Tacro (STRATO) Completed
  3. Phase 3 Sodium Bicarbonate for Prevention of Contrast-Induced Nephropathy Completed
  4. Phase 3 GORE VIABAHN Endoprosthesis Versus Percutaneous Transluminal Angioplasty (PTA) to Revise AV Grafts in Hemodialysis Completed
  5. Phase 3 Safety and Efficacy of LCP-Tacro™ Once Daily in Stable Renal Transplant Patients Converted From Prograf® Twice Daily Completed
  6. Phase 3 Double-Blind,Double-Dummy,Efficacy/Safety,LCP-Tacro™ Vs Prograf®,Prevention Rejection,De Novo Adult Kidney Tx Completed
  7. Phase 2 Pharmacokinetics of LCP-Tacro(TM) Once Daily And Prograf® Twice A Day in Adult De Novo Kidney Transplant Patients Completed
  8. Phase 2 Multicenter, Prospective, Rand, PK Study of LCP-Tacro™ Compared to Prograf® Capsules in De Novo Adult Kidney Transplant Completed
  9. Phase 2 Safety and Efficacy Assessment of HAV in Patients Needing Vascular Access for Dialysis Completed
  10. Phase 2 Does Nesiritide Provide Renal Protection Completed
  11. Phase 2 Pharmacokinetics of LCP-Tacro in Stable Kidney Transplant Patients Completed
  12. N/A VasQ External Support for Arteriovenous Fistula Completed
  13. N/A Comparing Everolimus and Sirolimus in Renal Transplant Recipients Completed
  14. N/A Buttonhole Versus Step Ladder Cannulation in High Dose Hemodialysis Completed
  15. N/A The Prevention of Failure to Rescue Using Early Warning Scoring Completed
  16. N/A Improving Patient Prioritization During Hospital-homecare Transition Completed
  17. N/A Metabolites of Tramadol in the Postoperative Surgical Patients Completed
  18. N/A Quanta Home Run Trial Completed
  19. N/A Long-term Effects of Intensive Insulin Treatment in Type 1 Diabetes Completed
  20. N/A Conversion to Everolimus From Calcineurin Inhibitor With Mycophenolic Acid: Impact on Long Term Renal Function in Liver Transplantation. Completed

Showing the 26 most-cited and recently-updated of 26 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Renal failure: what the trials found

Management of renal failure involves several pharmacological and procedural interventions. For patients requiring transplant, LCP-Tacro has been evaluated for efficacy; one study reported a low composite endpoint for efficacy failure within 12 months 7. Additionally, switching from Prograf to LCP-Tacro in stable kidney transplant patients was associated with a significant reduction in hand tremors (p=0.0048) 9.

Prograf (tacrolimus) has been studied extensively for transplant outcomes; data showed no statistically significant difference in treatment failures at 12 months (p=0.999) or 24 months (p=0.835) across compared groups 8. Other pharmacological interventions include the use of sodium bicarbonate 12, ferric citrate 5, and Heme Iron Polypeptide (Proferrin), which showed stable hemoglobin concentrations at 6 months 11.

Cardiovascular and metabolic management in renal patients includes the use of 10mg Rosuvastatin 13. For vascular access, the GORE VIABAHN Endoprosthesis with PROPATEN Bioactive Surface demonstrated significantly higher target lesion primary patency at 6, 12, and 24 months compared to standard alternatives (p=0.008) 10.

Alternative surgical materials such as Human Acellular Vessel (HAV) have been evaluated in phase 3 trials for renal-related applications 4.

Recent results — preliminary, needs further review

  • VasQ was investigated in a recent trial 1.
  • The PREVENT clinical decision support tool was evaluated regarding rehospitalizations within 60 days after hospital discharge 19.

For the clinician treating this condition

  • LCP-Tacro may be an effective alternative to Prograf for managing hand tremors in stable kidney transplant patients.
  • GORE VIABAHN Endoprosthesis with PROPATEN Bioactive Surface shows superior patency rates over 24 months compared to standard options.
  • Standard interventions such as Rosuvastatin, sodium bicarbonate, and ferric citrate are established components of management.

AI synthesis of 11 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

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