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Home › Conditions › Respiratory Insufficiency

Respiratory Insufficiency

0 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Respiratory Insufficiency

20 trials tracked for Respiratory Insufficiency: 3 in phase 3 or 4 and 2 with published results. The most-cited published study has 63 citations.

20Trials tracked
3Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 1 Phase 3 2 Phase 1 1 Other / NA 16
  1. Phase 3 A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients Completed · 63 cited
  2. Phase 3 Astral VAPS AutoEPAP Clinical Trial Completed · 41 cited
  3. Phase 4 Effect of Neuromuscular Blockade and Reversal on Breathing Completed
  4. Phase 1 Nasal High Frequency Ventilation in Preterm Infants: A Pilot Study Completed
  5. N/A Clinical Efficacy in Relief of Dyspnea by HVNI: Evaluation of New Cannulae Designs Completed
  6. N/A Extracorporeal Lung Assist to Avoid Intubation in Patients Failing Noninvasive Ventilation for Hypercapnic ARF Completed
Show 14 more trials
  1. N/A HVNI Ambulation Feasibility Study Completed
  2. N/A Novel Non-Invasive Monitoring Parameter in a Hospital Setting Completed
  3. N/A Behavioral Activation-Rehabilitation to Improve Depressive Symptoms & Physical Function After Acute Respiratory Failure Completed
  4. N/A RCT of Mesh Versus Jet Nebulizers on Clinical Outcomes During Mechanical Ventilation in the Intensive Care Unit Completed
  5. N/A A Feasibility Study Evaluating the Use of a Non-invasive Ventilation Mask Completed
  6. N/A Pulmonary Rehabilitation in Patients Before Lung Transplantation (LTx) Completed
  7. N/A The Impact of High-Flow Nasal Cannula on Swallow Function Completed
  8. N/A Randomized Crossover of NAVA and Synchronized Intermittent Pressure Ventilation in Neonates and Infants Completed
  9. N/A Assessment of an Endotracheal Tube Securement Device Completed
  10. N/A Cross-over Comparison of the V60 System to Other Bi-Level Noninvasive Ventilators Completed
  11. N/A Helmet Continuous Positive Airway Pressure (CPAP) Versus Oxygen Venturi in Severe Acute Respiratory Failure in Pneumonia Completed
  12. N/A Adjustment of Mask Pressure, for Bilevel Positive Airways Pressure Therapy, by Automated Algorithm Completed
  13. N/A Trilogy Comparison Study - Adults Completed
  14. N/A Study of the Usability and Efficacy of a New Pediatric CPAP Mask Completed

Showing the 20 most-cited and recently-updated of 20 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Respiratory Insufficiency: what the trials found

Astral was shown to significantly improve clinical markers by reducing the Oxygen Desaturation Index 4% (ODI4%) from 7.61 to 3.16 (p=0.0134) 3.

The administration of Sugammadex did not result in a statistically significant increase in breathing due to a reduction in inspired oxygen saturation (Hypoxic Ventilatory Response) 1.

Recent results — preliminary, needs further review

  • Behavioral Activation - Rehabilitation showed an EQ-5D-5L utility score of 0.80, though basic mobility scores remained similar between groups 5.

For the clinician treating this condition

  • Astral is associated with a significant reduction in the Oxygen Desaturation Index (ODI4%) 3.
  • Sugammadex does not significantly impact breathing via the hypoxic ventilatory response 1.

AI synthesis of 3 cited trials, updated Aug 21, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
No published articles yet for this condition. Check back soon.