Research across Schizophrenia
Related studies from across the Schizophrenia family.
Higher baseline PANSS negative symptom severity associated with lower risk of symptom exacerbation
Higher Baseline Negative Symptoms Linked to More Stable Schizophrenia Course
This RCT of 1139 adults with schizophrenia found that patients in the medium and high baseline PANSS negative symptom tertiles had a lower r…
People with schizophrenia who have more severe negative symptoms at the start of treatment may experience fewer sudden flare-ups over 18 mon…
Meta-analysis finds no atypical reliance on priors in schizophrenia-spectrum psychosis
New findings clarify how the brain processes information in people with schizophrenia
This meta-analysis of behavioral measures found no evidence for atypical reliance on priors in adults with schizophrenia-spectrum psychosis …
Researchers looked at how people with schizophrenia process information. They found no evidence for a general flaw in how the brain predicts…
Barriers to mental health care for Black populations include racism, stigma, and socioeconomic determinants
Barriers to mental health care for Black patients identified
This scoping review of 254 sources identifies prevalent mental health disorders and systemic barriers affecting the Black population. Key fi…
New research highlights how racism, stigma, and lack of access create significant hurdles for Black people seeking mental health care.
Semaglutide and liraglutide are associated with the greatest weight reductions in patients with schizophrenia
New data shows weight loss options for people with schizophrenia
This network meta-analysis of 5898 patients with schizophrenia spectrum disorders evaluated pharmacological interventions for weight reducti…
New data identifies specific medications that help people with schizophrenia manage weight gain while staying on their standard antipsychoti…
Aerobic exercise combined with tai chi may reduce Positive and Negative Syndrome Scale scores
Exercise and yoga may help manage symptoms of schizophrenia
This network meta-analysis of 2628 individuals with schizophrenia evaluated the efficacy of aerobic exercise, yoga, and tai chi. The analysi…
New research suggests that aerobic exercise, yoga, and tai chi could help reduce both positive and negative symptoms in people with schizoph…
5-HTR antagonists improve negative symptoms and cognition in schizophrenia, meta-analysis finds
New medications show promise for schizophrenia symptoms and cognition
This meta-analysis of 730 patients with schizophrenia found that adjunctive 5-HTR antagonists (setrons, CVN058, vortioxetine) significantly …
New research suggests specific medications may help manage the difficult cognitive and negative symptoms of schizophrenia.
AGE levels significantly elevated in schizophrenia-spectrum disorders, meta-analysis finds
Higher Levels of AGEs Linked to Schizophrenia Spectrum Disorders
This meta-analysis of 584 patients and 630 controls found significantly higher advanced glycation end products (AGEs) in schizophrenia-spect…
A large review of data shows that people with schizophrenia-spectrum disorders have significantly higher levels of AGEs in their blood and s…
Paliperidone ER and LAI show no significant difference in personal and social performance scores
Paliperidone Treatment Shows Improvement in Schizophrenia Social Performance
This meta-analysis of 20 RCTs and 38 single-arm trials indicates that both paliperidone ER and LAI significantly improve Personal and Social…
Paliperidone in both oral and injectable forms shows significant improvements in social and personal performance for people living with schi…
Dementia prevalence 24.3% in older adults with psychotic disorders, meta-analysis finds
Dementia found in 1 in 4 older adults with psychotic disorders
This meta-analysis of older adults with psychotic disorders reports a pooled dementia prevalence of 24.3% (95% CI: 20.5%-28.5%), with high h…
A new analysis finds dementia in 24.3% of older adults with psychotic disorders, highlighting the need for better care planning.
253 autism-associated genes identified via rare coding variation in 62,429 individuals
253 genes linked to autism may also affect other conditions
This meta-analysis of exome sequencing data from over 1.5 million individuals identified 253 autism-associated genes and 497 genes impacting…
A massive genetic study found 253 autism-linked genes, many tied to other brain and body conditions, opening new paths for understanding.
Lithium-associated nephrogenic diabetes insipidus may cause severe postoperative hypernatremia and polyuria
Lithium use may cause kidney issues after surgery in patients
This case report describes a patient with schizophrenia and type 2 diabetes who developed severe hypernatremia and polyuria following a panc…
A man with schizophrenia and diabetes faced severe complications after surgery, highlighting how lithium can affect kidney function and flui…
Schizophrenia polygenic scores associate with neonatal DNAm at 246 loci in cord blood samples
Cord blood markers linked to risk of autism and schizophrenia
This meta-analysis of 5802 individuals from 4 European cohorts identified associations between genetic susceptibility to schizophrenia and n…
New research shows specific patterns in newborn cord blood can signal a genetic risk for conditions like autism and schizophrenia.