Eltrombopag addition alters clonal hematopoiesis dynamics in untreated severe aplastic anemia patients over 24 months
Adding Eltrombopag helps severe anemia patients recover blood counts significantly faster
This Phase 3 randomized trial reviewed patient samples from 170 untreated patients with severe or very severe aplastic anemia receiving eltr…
Adding Eltrombopag helps severe anemia patients recover blood counts faster without increasing cancer risks but genetic changes rise over ti…
Eltrombopag plus immunosuppression for severe aplastic anemia shows clonal evolution patterns
Treatment for severe anemia reveals two paths to cancer risk
This phase 2 observational study followed 204 patients with severe aplastic anemia treated with immunosuppression plus eltrombopag for a med…
New research tracks cancer risks in severe anemia patients treated with standard therapy over five years
Pretreatment sTNFR1 and infection predict transplant-associated thrombotic microangiopathy in severe aplastic anemia
A simple blood test may flag a deadly transplant complication before it starts
This prospective nested case–control study evaluated patients with severe aplastic anemia undergoing allogeneic hematopoietic stem cell tran…
A blood marker measured before transplant may flag a deadly complication in severe aplastic anemia patients.
Eltrombopag monotherapy assessed in moderate aplastic anemia and unilineage bone marrow failure disorders
Oral Drug May Reduce Need for Frequent Blood Transfusions
This Phase 2 trial evaluated eltrombopag by mouth once a day in 34 people at least 2 years of age with moderate aplastic anemia or unilineag…
A new oral medication offers hope for patients who rely on regular blood transfusions.
Research across Anemia
Related studies from across the Anemia family.
Roxadustat increases odds of vascular access thrombosis and all-cause mortality in patients with chronic kidney disease
Roxadustat Linked to Higher Risk of Blood Clots in Kidney Patients
This systematic review and meta-analysis of 11,418 adults with chronic kidney disease found that roxadustat is associated with higher odds o…
A review of over 11,000 patients suggests roxadustat may increase the risk of blood clots and death for those with chronic kidney disease.
Vitamin D improves strength and reduces injuries in dancers, while iron lowers anemia prevalence
Dancers take many supplements, but benefits are often unproven and risks remain unclear
This systematic review of dietary supplement and medication use in 654 female and 86 male professional and pre-professional dancers found vi…
Dancers use many supplements and painkillers, yet benefits are limited and potential health risks need more study before we can trust them.
Systematic review and meta-analysis finds roxadustat improves hemoglobin in peritoneal dialysis patients
Roxadustat Boosts Hemoglobin in Peritoneal Dialysis Patients
This systematic review and meta-analysis of 607 patients receiving peritoneal dialysis found that roxadustat significantly increased hemoglo…
A review of 607 patients on peritoneal dialysis finds roxadustat raises hemoglobin and iron levels while lowering hepcidin.
Systematic review and meta-analysis of liposomal iron versus conventional iron in pediatric iron deficiency anemia
Liposomal iron improves blood counts and reduces side effects in children with anemia
This systematic review and meta-analysis evaluated liposomal iron versus conventional oral iron in 454 children with iron deficiency anemia …
A meta-analysis found liposomal iron raised hemoglobin more and caused fewer side effects than conventional iron in children.
Systematic review examines early erythropoiesis-stimulating agents for preterm infants across multiple clinical outcomes and safety endpoints
Early blood boosters may lower severe brain injury risk in premature babies
A systematic review of 37 trials involving 6,724 preterm or low-birthweight infants found that early erythropoiesis-stimulating agents likel…
A review of 37 studies suggests early blood boosters might lower severe brain injury and severe gut illness in premature infants without rai…
Systematic review and meta-analysis of erythropoiesis-stimulating agents in chronic heart failure and anaemia
New drugs help heart failure patients stay out of the hospital
This systematic review and meta-analysis evaluated erythropoiesis-stimulating agents (ESAs) in adults with chronic heart failure and anaemia…
A new review shows specific drugs can keep heart failure patients out of the hospital while improving their daily energy and movement.
Iron micronutrient powders reduce malaria-induced anaemia but not growth in young children
Iron powders reduce malaria-related anaemia in young children
This cluster-randomized trial in 1,806 Ghanaian children aged 6-35 months found that daily iron-containing micronutrient powders for five mo…
Daily iron-based micronutrient powders can lower the risk of malaria-induced anaemia in preschool children in Ghana.
Systematic review and meta-analysis shows dapagliflozin increases hemoglobin in chronic kidney disease patients
Common Diabetes Drug May Help Anemia in Kidney Disease
This systematic review and meta-analysis evaluated dapagliflozin in chronic kidney disease (CKD) patients with anemia.
This study suggests a common diabetes drug could treat anemia in kidney patients without the risks of current options.
Hematocrit–albumin gap linked to sepsis risk in ICU adults in retrospective analysis
Does a simple blood number predict sepsis risk in ICU patients?
A retrospective cross-sectional analysis of 19,134 adults with first ICU admissions found that a higher hematocrit–albumin gap (HAG) was ass…
A simple blood number called the hematocrit–albumin gap predicts sepsis risk in ICU patients, with higher levels increasing infection odds b…
Scoping review identifies poor health outcomes in children under seven with care experience in high-income countries
Young Children in Care Face Hidden Health Risks
This scoping review synthesizes evidence from 36 articles regarding children under seven years in high-income countries with care experience…
Young children in foster or kinship care face hidden physical health risks like poor growth, dental problems, and low vaccination rates befo…
Total IgG Concentration Linked to Anemia in Hemodialysis Patients
Is low immunity linked to anemia in dialysis patients, or just age?
This cross-sectional study included 351 participants, comprising 179 dialysis patients and 172 healthy controls.
Dialysis patients with weaker overall immune defenses are more likely to have anemia, while protection from chickenpox offers little clue ab…
Video capsule endoscopy in children shows diagnostic yield for Crohn's disease but requires endoscopic placement
Tiny Camera Spots Crohn's Damage That Scans Miss in Kids
A retrospective single-center study of 60 children undergoing 76 VCE examinations found VCE supported new Crohn's diagnosis in 46% of cases …
A tiny swallowed camera found gut inflammation missed by standard scans in children with Crohn's disease, changing treatment plans for more …
Questions about severe aplastic anemia
What clonal evolution patterns are seen in severe aplastic anemia treated with eltrombopag and immunosuppression?
Treatment with eltrombopag and immunosuppression leads to an increase in clonal mutations over time, with two main patterns of evolution: early changes involving chromosome 7 and late changes driven by pre-existing clones that can progress to cancer or PNH.
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