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Home › Conditions › Sexually Transmitted Diseases

Sexually Transmitted Diseases

Part of Sexually Transmitted Infections

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Sexually Transmitted Diseases

35 trials tracked for Sexually Transmitted Diseases: 6 in phase 3 or 4 and 4 with published results. The most-cited published study has 2 citations.

35Trials tracked
6Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 3 Phase 3 3 Phase 2 6 Phase 1 1 Other / NA 22
  1. Phase 3 Evaluation of EVO100 for Prevention of Urogenital Chlamydia Trachomatis and Neisseria Gonorrhoeae Infection Completed · 2 cited
  2. Phase 4 Combo-PEP: Multipurpose Prevention of Post-Exposure Prophylaxis Regimens Completed
  3. Phase 4 Doxy-Post-exposure Prophylaxis Completed
  4. Phase 3 Our Family Our Future: A Resilience-oriented Family Intervention to Prevent Adolescent HIV/STI Infection and Depression in South Africa Completed
  5. Phase 4 Mesalamine to Reduce T Cell Activation in HIV Infection Completed
  6. Phase 3 Reducing Sexual Risk Behaviors and Improving Health for People at a Sexually Transmitted Infection Clinic Completed
Show 29 more trials
  1. Phase 2 A Peer-Oriented HIV Prevention Outreach Program for Individuals at High Risk for HIV and Other STIs Completed
  2. Phase 2 Evaluation of Many Men, Many Voices, An STD/HIV Prevention Intervention for Black MSM Completed
  3. Phase 2 Safety of and Immune Response to a Novel Human Papillomavirus Vaccine in HIV Infected Children Completed
  4. Phase 2 Safety of and Immune Response to the Human Papillomavirus (HPV) Vaccine in HIV-Infected Women Completed
  5. Phase 2 Addressing Heavy Alcohol Use Consumption With Kudzu Completed
  6. Phase 2 A Placebo-Controlled Study Using VP-102 in the Treatment of External Genital Warts Completed
  7. Phase 1 Innovative Tools to Expand HIV Self-Testing Completed
  8. N/A Mobile-Based Application "MyChoices" Completed
  9. N/A Increasing Engagement and Improving HIV Outcomes Via HealthMPowerment Completed
  10. N/A Reducing HIV Vulnerability Through A Multilevel Life Skills Intervention For Adolescent Men Completed
  11. N/A Enhanced SexHealth Intervention to Improve Adolescent Outcomes Completed
  12. N/A Reducing HIV Risk Among Adolescents: Evaluating Project HEART Completed
  13. N/A Effectiveness of an Online Prevention Program in Reducing the Risk of STD Infection in Young Adults Completed
  14. N/A Aspiring to Awesome- Patient Preference Privacy Selections in EMR Completed
  15. N/A A Pilot Peer Mentor Intervention That Trains Black Men Who Have Sex With Men (BMSM) to Use and Promote Uptake of HIV/STI Self-Testing to Peers and Sex Partners: STAR Study (Self-Testing at Your Residence) Completed
  16. N/A Reducing HIV Risk Among Adolescents: Evaluating HEART for Teens Completed
  17. N/A Women SHARE Study: Reducing Sexual Risk Completed
  18. N/A Preventive Sexual Health Screening Among Female-to-Male (FTM) Transgender Adult Patients Completed
  19. N/A P3 (Prepared, Protected, emPowered) Completed
  20. N/A Health and Justice: A Continuum of Care for HIV and SU for Justice-Involved Young Adults (PHASE 2) Completed
  21. N/A The OPENS Trial: Offering Women PrEP (Aim 1) Completed
  22. N/A Zenyth: Motivational Interviewing-based Telehealth Intervention for Bacterial Sexually Transmitted Infection Screening Completed
  23. N/A Development and Evaluation of an HIV, STD, and Pregnancy Prevention Program for Middle School Students Completed
  24. N/A Randomized Evaluation of a Multi-Component, Rights-Based Sexuality Education Initiative for High School Students Completed
  25. N/A Men Together Making a Difference: Reducing HIV/STD Risk Behavior Among South African Men Completed
  26. N/A Efficacy of an Abstinence-Only HIV Risk-Reduction Intervention for Young African-American Adolescents Completed
  27. N/A Multi-component Intervention to Train Providers to Promote PrEP for Girls and Women in the Deep South Completed
  28. N/A LYNX: A Novel Mobile App to Support Linkage to HIV/STI Testing PrEP for Young Men Who Have Sex With Men Completed
  29. N/A Puerto Rico Cuidalos Parent-adolescent Program Completed

Showing the 35 most-cited and recently-updated of 35 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Sexually Transmitted Diseases: what the trials found

Doxycycline was evaluated for its presence in vaginal tissues, with concentrations measured at 0.590 and 1.534 following the fifth dose 2.

The intervention 'Our Family Our Future' was conducted in a Phase 3 trial 6.

In a study involving DVD 1, the number of sexual partners remained relatively stable across three follow-up periods (3, 6, and 9 months) post-intervention 7.

Recent results — preliminary, needs further review

  • Standardized kudzu was evaluated in a Phase 2 trial regarding binge drinking days 1.
  • A PrEP Pro training intervention was conducted 14.
  • Motivational interviewing and specimen self-collection were utilized to improve session attendance and specimen return rates 15.

For the clinician treating this condition

  • Doxycycline concentrations in vaginal tissues were documented following a 5-dose regimen 2.
  • Interventions such as 'Our Family Our Future' and DVD 1 have been evaluated in Phase 3 clinical settings [6, 7].

AI synthesis of 6 cited trials, updated Jun 23, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Surveillance describes characteristics of persons seeking care at sexually transmitted disease clinics
Infectious Disease
Surveillance describes characteristics of persons seeking care at sexually transmitted disease clinics Health officials monitor characteristics of people visiting STD clinics across 14 U.S. sites
A surveillance summary from 14 STD Surveillance Network sites in the United States describes characteristics of persons seeking care at STD …
Public health officials track who visits STD clinics at 14 sites across the United States to guide better care planning.
CDC Apr 6, 2026

Research across Sexually Transmitted Infections

Related studies from across the Sexually Transmitted Infections family.

Scoping review of partner notification barriers and facilitators for youth with STIs in sub-Saharan Africa
OB/GYN & Women's Health Cohort
Scoping review of partner notification barriers and facilitators for youth with STIs in sub-Saharan Africa Why is telling partners about STIs so hard for young people in Southern Africa?
This scoping review synthesizes evidence from three studies on partner notification for sexually transmitted infections among youth (ages 15…
Young people in Southern Africa struggle to tell partners about STIs due to fears and heavy social pressure, making this key infection contr…
Frontiers Apr 20, 2026
Meta-analysis finds doxycycline prophylaxis reduces STI risk in MSM and transgender women
Infectious Disease Meta-analysis
Meta-analysis finds doxycycline prophylaxis reduces STI risk in MSM and transgender women A Common Pill Could Slash Your Risk of Common STIs
A systematic review and meta-analysis of 14 studies in men who have sex with men and transgender women found doxycycline prophylaxis reduced…
A major review of the latest science confirms that a simple antibiotic, taken strategically, offers powerful new protection against chlamydi…
Apr 12, 2026
Meta-analysis finds 47% inconsistent condom use among female sex workers in Africa
Infectious Disease Meta-analysis
Meta-analysis finds 47% inconsistent condom use among female sex workers in Africa Half of African sex workers skip condoms. Here is why
A systematic review and meta-analysis of 23,496 female sex workers across African countries found a pooled prevalence of inconsistent condom…
Simple changes like better condom supply and mental health support could save lives right now.
Apr 12, 2026
Guideline published on sexually transmitted infections without specific study details
Infectious Disease
Guideline published on sexually transmitted infections without specific study details New guidelines released for sexually transmitted infection testing and treatment
A guideline document addresses sexually transmitted infections, but provides no information about study type, population, or specific findin…
New CDC guidelines update how doctors test for and treat sexually transmitted infections based on current medical evidence.
CDC Apr 6, 2026
Observational report describes coinfections with monkeypox, HIV, and STIs in U.S. patients
Infectious Disease
Observational report describes coinfections with monkeypox, HIV, and STIs in U.S. patients What happens when monkeypox, HIV, and other STIs overlap in the same person?
An observational report from eight U.S. jurisdictions described coinfections with monkeypox, HIV, and sexually transmitted infections among …
A new report shows people with monkeypox can also have HIV and other sexually transmitted infections, giving health providers a clearer pict…
CDC Apr 5, 2026