Early transanal irrigation improves constipation and independence in spinal cord injury patients
New Standard for Spinal Injury Bowel Care Emerges
This prospective, randomized, open-label, multicenter, parallel group study enrolled 22 SCI patients across four Italian spinal units.
Alex, 34, spent weeks in rehab after a spinal cord injury.
Retrospective study links SMA type 1 to higher hip instability prevalence in children
Hip Instability in SMA: What New UAE Data Reveals
This retrospective cross-sectional study evaluated 54 children with a genetic diagnosis of spinal muscular atrophy at a single United Arab E…
This study shows that hip instability is a major issue for children with SMA, especially those with the most severe form, and highlights the…
Secondary analysis of pooled ALS trial data reveals entropy-based functional domain trajectories
New Method Reveals Hidden Treatment Signals in ALS Trials
This secondary analysis of pooled clinical trial data from the PRO-ACT database examined Shannon entropy trajectories of ALSFRS functional d…
This study suggests that the way we measure success in ALS clinical trials might be hiding real treatment benefits, and a new mathematical a…
Meta-analysis finds rTMS improves neuropathic pain in spinal cord injury patients
rTMS may ease nerve pain after spinal cord injury, but not anxiety or depression
This meta-analysis of 7 RCTs with 159 patients found repetitive transcranial magnetic stimulation (rTMS) significantly improved neuropathic …
A review of seven trials found that repetitive magnetic stimulation reduced neuropathic pain in spinal cord injury patients, but did not sig…
Systematic review and meta-analysis of Danshen for spinal cord injury in animal models
This Common Herb May Help Spinal Cord Injuries Heal Faster
This systematic review and meta-analysis of 35 randomized controlled trials in animal models of spinal cord injury found that Danshen extrac…
A common Chinese herb may help spinal cord injuries heal faster by reducing swelling and protecting nerve cells, but human studies are still…
Narrative review discusses exosomes for spinal cord injury without reported outcomes or safety data
Could exosomes help heal spinal cord injuries, but this review offers only ideas, not proof
This narrative review examines the potential of exosomes derived from various cell sources for treating spinal cord injury.
Exosomes might one day help repair broken spinal cord connections, but this review only gathers existing ideas without testing them on real …
Masitinib 4.5 mg/kg/day associated with survival in ALS post-hoc analysis
This Drug Could Add Nearly Two Years to ALS Life
This post-hoc analysis of a randomized, double-blind, placebo-controlled trial in 130 ALS patients found that masitinib 4.5 mg/kg/day was as…
A new look at data suggests a specific drug might significantly extend life for some people with ALS.
Meta-analysis links speech features to severity in Parkinsons, cerebral palsy, and ALS
Speech patterns may help track disease severity in Parkinsons and other conditions
This meta-analysis synthesizes evidence from 890 speakers across 5 languages to evaluate a training-free method for assessing speech degrada…
A new computer method tracks Parkinson's and other disease severity by measuring how specific speech sounds change without needing special t…
Cross-sectional CSF proteomic analysis identifies ALS-specific biomarker signature
ALS Blood Test Breakthrough Could Speed Diagnosis
This observational cross-sectional study analyzed CSF proteomics in 237 participants to identify ALS-specific biomarkers.
A new five-protein blood test pattern could finally help doctors spot ALS early, before nerve damage becomes too advanced.
Systematic review finds gut microbiome dysbiosis associated with ALS progression
Could gut bacteria changes be linked to ALS, or just happen alongside it?
This systematic review with narrative synthesis examined 61 studies on gut microbiome alterations in ALS.
People with ALS often show reduced gut bacteria diversity, but it is still unclear if these changes cause the disease or simply happen along…
Observational study finds no association between ZFHX3 GGC repeat expansions and ALS risk
New DNA Scan Rules Out ALS Link
This observational research article examined ZFHX3 GGC repeat expansions in 5,785 people with ALS and 7,982 healthy controls.
A major genetic test confirms that a specific repeat in your DNA does not cause ALS, even though it can cause a different movement disorder.
REDDI pipeline improves balanced accuracy for classifying MCI, MS, Parkinson's, and ALS using MEG data
Can a new computer tool help doctors spot brain diseases faster and more accurately?
This study developed a machine learning framework called REDDI that utilizes MEG resting-state data and Riemannian geometry for classifying…
A new computer tool helps doctors distinguish between hard-to-tell-apart brain diseases like Parkinson's and ALS with 13% better accuracy.