Systematic review validates iPSC-derived organoids as models for ALS pathology compared to traditional 2D or animal models
Scientists Grow Tiny ALS Brains in Labs — What It Could Mean
This systematic review evaluated in vitro organoid models derived from human-specific neural and neuromuscular subtypes for Amyotrophic Late…
For the first time, scientists can watch ALS unfold in human tissue grown outside the body — which could speed up the search for treatments …
Canadian policies for spinal cord injury supplies vary widely, often relying on means-testing rather than medical need
Over 80,000 Canadians with spinal cord injuries face funding gaps that limit their daily independence and safety
This systematic review examined health care delivery for over 80,000 Canadians with spinal cord injury across provincial and federal levels.
Over 80,000 Canadians with spinal cord injuries face funding gaps that limit their daily independence and safety.
Pilot RCT finds Cognitive Multisensory Rehabilitation may improve sensorimotor function in spinal cord injury
A New Kind of Therapy Rewires the Brain to Ease Spinal Cord Pain
A pilot RCT of 16 adults with spinal cord injury compared Cognitive Multisensory Rehabilitation (CMR) to adaptive fitness.
Early research suggests a therapy focused on rebuilding the brain's map of the body can offer lasting relief where medications often fail.
Muscle ultrasonography shows high diagnostic accuracy for fasciculation detection in ALS
A Simple Scan Could Speed Up an ALS Diagnosis
A systematic review and meta-analysis of 13 studies involving 1,176 participants found muscle ultrasonography has high sensitivity (0.87) an…
A common ultrasound machine may help doctors spot a key sign of ALS more quickly, potentially shortening the difficult diagnostic journey.
Narrative review examines autonomic modulation strategies for spinal cord injury recovery
Fixing the Body's Wiring for Spinal Cord Recovery
A narrative review synthesizing emerging evidence (2020–2025) examines autonomic modulation strategies for spinal cord injury.
High stress blocks spinal cord healing by stopping the brain from rewiring, so calming the body is just as important as physical therapy for…
FDG-PET reveals dysregulated glucose metabolism as a common feature across late-onset neurodegenerative diseases with unique patterns
FDG-PET scans show common brain glucose changes across several late-onset neurodegenerative diseases
This meta-analysis of 5,412 individuals with age-associated neurodegenerative diseases (A2ND) and 3,549 controls utilized FDG-PET to quantif…
FDG-PET scans reveal that dysregulated brain glucose metabolism is a shared feature across late-onset neurodegenerative diseases like Alzhei…
Plastic changes in brainstem reticular formation may be involved in spasticity onset across stroke and spinal cord injury
Could brainstem plastic changes trigger spasticity in stroke and spinal cord injury patients?
This systematic review examined pathophysiological similarities in spasticity among humans, primates, and rodents.
Spasticity after stroke or spinal cord injury may stem from plastic changes in the brainstem, though evidence remains limited and controvers…
First-in-human case study of BCI-spinal stimulation shows hand function gains in chronic tetraplegia
Can a brain-spine connection help someone with paralysis move their hand again?
A first-in-human case study in one individual with chronic, motor-complete cervical spinal cord injury tested a brain-computer interface pai…
A brain-spine connection helped a person with severe paralysis regain hand function, with improvements lasting even after therapy ended.
Spinal cord injury linked to altered cortical excitability response to repeated tDCS
Could a brain's 'reset button' work differently after spinal cord injury?
A crossover study in 20 adults with thoracic or below spinal cord injury and 20 healthy controls found greater corticomotor excitability fac…
After spinal cord injury, the brain's 'reset button' may weaken, leading to greater excitability and potentially explaining persistent sympt…
Hypnotic cognitive therapy reduces pain intensity in adults with spinal cord injury
Remote hypnosis therapy shows modest pain relief for adults with spinal cord injury
A randomized controlled trial in 127 community-residing adults with spinal cord injury and chronic pain found that 6 weeks of remote hypnoti…
Remote hypnosis therapy offered by phone or video call helped adults with spinal cord injury manage chronic pain and reduced depression symp…
Spinal cord ischemia recovery after TAAA repair improves from 35% at 3 months to 63% at 24 months
Many patients show functional recovery from spinal cord injury after complex aortic surgery
A retrospective single-center cohort study of 218 patients with postoperative spinal cord ischemia after thoracoabdominal aortic aneurysm re…
Spinal cord injury patients often regain significant function years after complex aortic surgery, with recovery rates rising from 35% to 63%…
Meta-analysis finds no significant association between statin use and ALS survival outcomes
Do statins help people with ALS live longer? A new analysis finds no clear link
A meta-analysis of 3,739 ALS patients (889 statin users) from six studies found no statistically significant association between statin use …
A new analysis of 3,739 people with ALS found no link between taking statins and living longer.