Meta-Analysis Reveals Shared Genetic Loci in Pediatric Nephrotic Syndrome and IgA Nephropathy
Genetic clues link immune cells to pediatric kidney disease risks
A meta-analysis of GWAS data identified nine genome-wide significant loci for pediatric steroid-sensitive nephrotic syndrome and 19 pleiotro…
A large genetic analysis connects specific immune cell pathways to pediatric kidney conditions, offering new targets for future treatments.
Mycophenolate mofetil non-inferior to prednisone for first-episode nephrotic syndrome in children
Mycophenolate Mofetil Offers Alternative to Steroids for Nephrotic Syndrome
This phase 3 non-inferiority trial randomized 272 children aged 1-10 years with first-episode steroid-sensitive nephrotic syndrome to mycoph…
A new trial shows mycophenolate mofetil works as well as prednisone for children with nephrotic syndrome, with fewer steroid side effects.
Atorvastatin evaluated for dyslipidemia in children with steroid-sensitive nephrotic syndrome
Can a common cholesterol drug protect children's hearts and kidneys from a hidden danger?
A quasi-experimental study of 100 children aged 8-18 years with steroid-sensitive nephrotic syndrome and dyslipidemia evaluated the effectiv…
A common cholesterol drug called atorvastatin may help children with kidney disease reach safer heart and blood fat levels when diet alone i…
Research across Kidney Diseases
Related studies from across the Kidney Diseases family.
SLE patients have a 2- to 3-fold higher risk of intracerebral hemorrhage compared to non-SLE populations
Lupus Patients Face Higher Risk of Brain Bleeding
This literature review and case report analyze the association between systemic lupus erythematosus (SLE) and intracranial hemorrhage (ICH).…
Patients with systemic lupus erythematosus may face a much higher risk of brain bleeds compared to those without the condition.
Case report and review on autoimmune nodopathy with Sjogren's disease and nephrotic syndrome
A rare case report shows intravenous methylprednisolone therapy improved neurological symptoms in a woman with autoimmune nodopathy
This is a case report and literature review on a 45-year-old woman with autoimmune nodopathy, Sjogren's disease, and nephrotic syndrome. The…
A 45-year-old woman with autoimmune nodopathy saw her neurological symptoms improve significantly after receiving intravenous methylpredniso…
Narrative review of salvianolic acids for kidney disease pharmacokinetics and anti-fibrotic activity
Salvianolic Acids Show Potential for Kidney Disease Treatment
This narrative review synthesizes evidence on salvianolic acids A, B, and C for kidney conditions. It focuses on pharmacokinetic parameters,…
A review suggests salvianolic acids may help kidney conditions, though low absorption and fast metabolism limit current use.
Meta-analysis shows Bailing Capsule improves markers in adult primary nephrotic syndrome with low adverse events
Bailing Capsule improves kidney markers and safety in adult nephrotic syndrome patients
This systematic review and meta-analysis of randomized controlled trials evaluated Bailing Capsule in 920 adult patients with primary nephro…
A review of trials shows Bailing Capsule helps reduce protein loss and improve kidney markers in adults with primary nephrotic syndrome.
Rituximab Shows Long-Term Remission in Pediatric Steroid-Dependent Nephrotic Syndrome
Rituximab Helps Kids With Kidney Swelling
This retrospective cohort study of 42 children with steroid-dependent or frequently relapsing nephrotic syndrome found that rituximab led to…
Imagine a child who needs medicine just to stay dry.
Case report describes obinutuzumab achieving renal remission in elderly podocytopathy with B-cell disorder
A Cancer Drug Cleared a Man's Failing Kidneys — and Doctors Aren't Sure Why
This single case report details the use of obinutuzumab in a 76-year-old male with podocytopathy and a suspected B-cell lymphoproliferative …
A blood cancer drug put a 76-year-old man's failing kidneys into complete remission within one month, offering hope for elderly patients wit…
Deep learning models predict first relapse in 562 adults with idiopathic nephrotic syndrome over 12 months
An AI Tool Can Now Predict Kidney Disease Flare-Ups Months Ahead
This retrospective cohort study evaluated deep learning models to predict first relapse within 12 months in 562 adult patients with idiopath…
A new AI model can identify which kidney patients are most likely to relapse within a year, potentially allowing doctors to act before sympt…
Rituximab exposure is associated with serum sickness in patients with multiple sclerosis, nephrotic syndrome, or immune thrombocytopenia
Can taking Rituximab cause a severe allergic reaction that returns if you take it again?
This retrospective review analyzed 39 published case reports of patients with rituximab-induced serum sickness (RISS).
Taking Rituximab can trigger a delayed allergic reaction that returns in most patients if the drug is given again, so doctors must use extre…
Case report: obinutuzumab and venetoclax associated with nephrotic syndrome resolution in two CLL patients
Two CLL patients saw kidney condition improve after targeted cancer treatment
A case report describes two patients with chronic lymphocytic leukemia (CLL) and concomitant nephrotic syndrome.
Two CLL patients saw kidney problems improve after targeted cancer treatment, resolving symptoms and reducing urine protein within weeks.
Obinutuzumab induced remission in FSGS patient after rituximab failure in case report
Obinutuzumab helped one patient with kidney disease after rituximab did not work
A case report describes a 33-year-old woman with primary FSGS and nephrotic syndrome who achieved complete remission after obinutuzumab foll…
When rituximab failed to stop protein leakage in a kidney disease patient, a single dose of obinutuzumab restored remission without side eff…