Germline BAP1 variants are associated with aggressive clinical phenotypes in patients with uveal melanoma
Genetic variants linked to more aggressive eye cancer cases
This systematic review examines the clinical phenotype of uveal melanoma in patients harboring germline pathogenic or likely pathogenic BAP1…
A specific genetic marker, BAP1, is linked to earlier diagnoses and higher risks of spreading in certain types of eye cancer.
Tebentafusp provides modest survival benefit and manageable safety profile in metastatic uveal melanoma
Trial Shows Tebentafusp Offers Survival Benefit for Metastatic Uveal Melanoma
This systematic review and meta-analysis of 631 patients evaluates tebentafusp for metastatic uveal melanoma. The analysis found an overall …
Tebentafusp shows a modest survival benefit for patients with metastatic uveal melanoma, despite low response rates and manageable side effe…
Network meta-analysis compares therapies for liver metastatic uveal melanoma
Liver-directed therapy combined with ICIs leads for metastatic uveal melanoma survival
This systematic review and network meta-analysis synthesized evidence on therapeutic modalities for patients with liver metastatic uveal mel…
A network meta-analysis of 2,585 patients found liver-directed therapy combined with immune checkpoint inhibitors offered the best survival …
Combined tebentafusp and SBRT showed disease control in a patient with metastatic uveal melanoma
One Woman’s Rare Eye Cancer Spread. Then a New Combo Stopped It Cold
This case report describes a 39-year-old woman with localized uveal melanoma who developed liver and hilar adenopathy metastases.
This story shows how combining a new immune drug with targeted radiation may help the body fight cancer longer, even after it has spread.
Immunoembolization shows lower disease control than FOCUS trial in liver-dominant metastatic uveal melanoma
Eye Cancer in Liver: New Therapy Extends Life Even When Tumors Grow
This single-center retrospective analysis evaluated immunoembolization (IE) in 43 patients with liver-dominant metastatic uveal melanoma.
A new liver treatment for eye cancer patients may help them live longer, even if it does not shrink tumors as much as expected.
Phase II trial compares IMCgp100 vs investigator choice in advanced uveal melanoma
Can a new drug help people with a rare eye cancer live longer?
This Phase II study evaluated IMCgp100 versus investigator's choice (dacarbazine, ipilimumab, or pembrolizumab) in HLA-A*0201 positive adult…
A new drug for advanced eye cancer is being compared to standard treatments to see if it helps patients with a specific genetic marker live …
Research across Melanoma
Related studies from across the Melanoma family.
AI-assisted clinicians achieve 1.000 sensitivity in melanoma diagnosis but autonomous AI lacks clear clinical advantage
Artificial Intelligence Shows Mixed Results in Detecting Melanoma
This meta-analysis of 17 diagnostic arms from 10 studies evaluates artificial intelligence for dermoscopic image analysis in melanoma detect…
New research shows that while AI can help identify skin cancer, it does not yet outperform traditional methods used by doctors.
Opsin 3 serves as a potential therapeutic target for melanoma and inflammatory skin diseases
Opsin 3 May Offer New Path for Skin Disease Treatment
This narrative review explores the role of Opsin 3 (OPN3) in skin pathophysiology, including its involvement in UV damage, melanoma developm…
A protein called Opsin 3 may play a key role in how skin cells respond to UV damage, aging, and inflammation.
AI diagnostic tools show high accuracy but limited real-world validation in systematic review
Artificial intelligence shows high accuracy in detecting various medical conditions
This systematic review of 24 studies synthesizes evidence on AI and deep learning for disease detection across multiple imaging modalities. …
New analysis of 24 studies shows AI tools can reach over 90% accuracy in spotting everything from lung cancer to skin disorders.
Actinic keratosis increases melanoma risk while alcohol consumption is associated with lower squamous cell carcinoma risk
Actinic Keratosis Linked to Higher Risk of Melanoma
This meta-analysis of genome-wide association studies evaluates causal relationships between 11 modifiable risk factors and skin cancers. Th…
New research identifies a link between actinic keratosis and melanoma risk while highlighting potential new targets for skin cancer treatmen…
Sugar sweetened beverages and orange juice are associated with increased risk of several cancer types
Sugar sweetened drinks may increase risk of several cancer types
This meta-analysis of 51 cohort studies evaluates the link between sugar sweetened beverages (SSBs), artificially sweetened beverages (ASBs)…
New research suggests a link between sugar-sweetened beverages and an increased risk of certain cancers, including pancreatic and colorectal…
Targeted cytokine delivery platforms in canine oncology provide data for human immuno-oncology dose selection
Cytokine Therapies Show Potential for Treating Canine Cancers
This mini review synthesizes evidence on targeted cytokine delivery platforms, such as IL-12 and IFN-beta, in dogs with various spontaneous …
New research explores how targeted cytokine delivery systems can treat various cancers in dogs and provide data for future human cancer trea…
IO102-IO103 plus pembrolizumab improves progression-free survival in advanced melanoma patients
Trial shows combination therapy may extend time before melanoma progresses
This Phase III randomized controlled trial of 407 patients with untreated advanced melanoma evaluated IO102-IO103 (85 μg) combined with pemb…
A new clinical trial suggests that combining two specific drugs may help patients with advanced melanoma stay stable for longer periods.
Motivation-informed digital reminders do not improve task completion compared to standard wording in melanoma trial
Standard Digital Reminders Work Well for Melanoma Monitoring Tasks
This randomized study within a trial (SWAT) of 260 participants in a melanoma surveillance program found that motivation-informed digital re…
New research shows that standard digital reminders are just as effective as motivation-based ones for helping patients complete melanoma mon…
Narrowband UVB remains first-line phototherapy for vitiligo, with JAK inhibitors emerging as adjuncts
New light therapies and skin grafts offer hope for vitiligo patients
This narrative review synthesizes current evidence on phototherapy for vitiligo, highlighting narrowband UVB as the mainstay. Excimer lasers…
A review of treatments for vitiligo highlights options like narrowband ultraviolet B light, excimer therapy, and cellular grafting that may …
Meta-analysis finds modest melanoma risk increase among infertile women using fertility treatments
Fertility Drugs Linked to Slight Rise in Melanoma Risk
This systematic review and meta-analysis evaluated melanoma incidence in infertile women exposed to fertility treatments compared to untreat…
A large review finds fertility drugs may raise melanoma risk slightly, but the increase is small and more research is needed.
TIL therapy and engineered viral vector immunotherapies show pooled ORR of 37.8% in advanced melanoma
First new analysis in years shows TIL therapy response rates for advanced melanoma
This Bayesian meta-analysis synthesizes data from 13 eligible studies on TIL therapy and engineered viral vector immunotherapies for advance…
A Bayesian meta-analysis of 13 studies finds TIL therapy yields a 49% response rate in advanced melanoma, with moderate certainty for respon…
Systematic Review: Intercellular Mitochondrial Transfer in Melanoma Progression and Resistance
Mitochondrial Transfer Fuels Melanoma Resistance and Spread
This systematic review examines the role of intercellular mitochondrial transfer in melanoma. The authors find that this process contributes…
A systematic review reveals that intercellular mitochondrial transfer helps melanoma resist therapies and spread, but may also suppress tumo…
Questions about Uveal Melanoma
Did a patient with uveal melanoma benefit from combined tebentafusp and SBRT?
Yes, a case report describes a patient with metastatic uveal melanoma who achieved durable disease control after adding SBRT to tebentafusp, with a partial response and 35 months of maintained control.
Full answer →What treatments are available for liver metastatic uveal melanoma patients?
Liver-directed therapy combined with immune checkpoint inhibitors appears most effective; tebentafusp is approved for HLA-A*02:01+ patients; other options include immunoembolization, SBRT, and clinical trials.
Full answer →How does immunoembolization compare to the FOCUS trial for uveal melanoma?
Immunoembolization shows lower disease control rates than the FOCUS trial for liver-dominant metastatic uveal melanoma, though tebentafusp combined with radiotherapy may offer durable control in specific cases.
Full answer →Can tebentafusp and SBRT control disease in uveal melanoma?
Yes, a case report shows tebentafusp plus SBRT controlled metastatic uveal melanoma for over 35 months, but more research is needed to confirm this approach.
Full answer →