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Home › Conditions › vaginal prolapse

Vaginal prolapse

Part of Pelvic organ prolapse

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for vaginal prolapse

7 trials tracked for vaginal prolapse: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 23 citations.

7Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 3 Phase 2 1 Other / NA 3
  1. Phase 4 Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen Completed · 23 cited
  2. Phase 4 Efficacy Study of Vaginal Mesh for Anterior Prolapse Completed
  3. Phase 4 Lessons on Urethral Lidocaine in Urodynamics Completed
  4. Phase 2 Dexamethasone Administration To Improve Patient Recovery In Ambulatory Vaginal Prolapse Surgery: Is There A Role? Completed
  5. N/A Observational Data Collection of Surgical Outcomes in the Treatment of Vaginal Prolapse With AMS Products Completed
  6. N/A Efficacy Study of Vaginal Mesh for Prolapse Completed
Show 1 more trials
  1. N/A Effect of Preoperative Fiber on Postoperative Bowel Function Completed

Showing the 7 most-cited and recently-updated of 7 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Vaginal prolapse: what the trials found

Clinical evidence for the management of vaginal prolapse includes surgical interventions and topical treatments. The use of synthetic polypropylene mesh was evaluated for objective treatment success in anterior prolapse, with results showing a primary outcome measure of Point Ba at Stage 0 or 1 (maximal descent of the anterior wall to greater than 1 cm above the hymen) at one year 3.

Non-surgical interventions have also been studied. Conjugated Estrogens Cream was evaluated in a Phase 4 trial 1. Additionally, a water-based vaginal lubricant demonstrated specific voiding metrics with a percentage of voiding efficiency reaching 94.6 and 95.9 2.

Recent results — preliminary, needs further review

  • Dexamethasone (Phase 2) is currently under investigation but not yet corroborated 4.
  • Synthetic monofilament polypropylene mesh showed significant results for anatomic cure at 3 years (p=<0.05) in a non-phased study 5.
  • Psyllium fiber and AMS Prolapse Product are being studied but lack established corroboration [6, 7].

For the clinician treating this condition

  • Synthetic polypropylene mesh is an established intervention for achieving objective treatment success in anterior prolapse 3.
  • Conjugated Estrogens Cream and water-based vaginal lubricants are established options, with the latter showing specific improvements in voiding efficiency metrics [1, 2].

AI synthesis of 5 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic review finds 54.8% of Indian women with reproductive morbidities seek treatment
OB/GYN & Women's Health Meta-analysis
Systematic review finds 54.8% of Indian women with reproductive morbidities seek treatment Half of Indian women ignore reproductive pain
This systematic review and meta-analysis examined health-seeking behavior for reproductive morbidities among Indian women.
Ignoring common reproductive problems like pelvic pain or irregular periods leads to worse health outcomes for millions of women in India.
Frontiers Apr 11, 2026

Research across Pelvic organ prolapse

Related studies from across the Pelvic organ prolapse family.

Systematic review of 41 RCTs evaluates surgical options for anterior compartment prolapse
ENT (Otolaryngology) Sys. Review
Systematic review of 41 RCTs evaluates surgical options for anterior compartment prolapse Researchers find prolapse surgery risks vary by method used
This systematic review synthesizes data from 41 randomized controlled trials involving 4531 women with anterior compartment prolapse.
Women choosing prolapse surgery face different risks depending on the method used, with long-term safety for mesh still unknown.
Cochrane Apr 25, 2026