Systematic review finds inflammatory markers elevated in Alzheimer's disease compared to healthy controls across 41 studies
Inflammatory markers linked to Alzheimer's and other dementia types
This systematic review and meta-analysis examined 41 eligible studies involving healthy controls and patients with various dementia subtypes…
A large review found that people with Alzheimer's and other dementias show higher inflammation than healthy people, though more research is …
Meta-analysis suggests high BMI causally increases vascular-related dementia risk via blood pressure mediation
Higher body weight linked to increased risk of vascular dementia
This Mendelian randomization meta-analysis evaluates the causal link between high body mass index and vascular-related dementia. The analysi…
A large genetic study shows that a higher body mass index (BMI) raises the risk of vascular-related dementia. High blood pressure plays a ke…
Bayesian network meta-analysis evaluates antidiabetic medications and dementia risk in 4,382,897 patients
Could diabetes drugs lower dementia risk, or raise it for some patients?
This Bayesian network meta-analysis synthesized data from 28 articles involving 4,382,897 patients to assess antidiabetic drugs and dementia…
Insulin and metformin cut dementia risk, but DPP4 inhibitors may double Alzheimer's risk compared to SGLT2 drugs in diabetes patients.
Mini-review synthesizes dementia risk and cognitive trajectories in individuals with schizophrenia
Do people with schizophrenia face a higher risk of dementia, and what does that mean for their care?
This mini-review examines the relationship between schizophrenia and dementia, covering Alzheimer's disease, vascular dementia, and other fo…
People with schizophrenia face a two- to threefold higher risk of dementia, but it's not a direct path to Alzheimer's—brain development, agi…
Body weight variability associated with increased dementia risk in meta-analysis of cohort studies
Large weight fluctuations linked to higher dementia risk in research review
A systematic review and meta-analysis of 16 cohort studies found that highest levels of body weight fluctuation were associated with increas…
Large swings in body weight are linked to a higher risk of dementia, including Alzheimer's and vascular types, but not general cognitive dec…
Research across Dementia
Related studies from across the Dementia family.
Rapid advancements in imaging and blood-based biomarkers are transforming the diagnosis and management of ADRD
New guidelines help doctors tell delirium from dementia
This clinical guideline provides a narrative review on the evolving diagnostic and treatment landscape for Alzheimer's disease and related d…
Delirium is acute and fluctuating; dementia is chronic. New guidelines help doctors tell them apart.
Extended occupational therapy showed no significant improvement in behavioral symptoms for dementia patients
Extended occupational therapy shows no added benefit for dementia
This randomized controlled trial evaluated community-dwelling adults with mild-to-moderate dementia in France. Participants received occupat…
Adding four more months of occupational therapy did not improve behavioral symptoms in people with mild-to-moderate dementia, compared to st…
GLP-1 receptor agonists may reduce cognitive decline in type 2 diabetes patients with dementia
GLP-1 drugs may slow cognitive decline in type 2 diabetes
A systematic review of systematic reviews and meta-analyses found that GLP-1 receptor agonists are associated with reduced overall cognitive…
A review of reviews suggests GLP-1 drugs like Ozempic may help protect memory and thinking in people with type 2 diabetes.
SLE linked to 53% higher odds of cognitive impairment in meta-analysis of 7 million
Lupus linked to higher risk of cognitive decline
This meta-analysis of 7 observational studies involving over 7 million participants found that systemic lupus erythematosus (SLE) is signifi…
People with lupus may face 53% higher odds of cognitive impairment, a large analysis finds.
Dog-assisted therapy significantly improves behavioral symptoms in dementia patients compared to routine care in a systematic review
Dog-assisted therapy improves behavior in dementia patients
This systematic review and meta-analysis of 10 randomized controlled trials evaluated dog-assisted therapy for patients with dementia. The p…
A meta-analysis suggests dog-assisted therapy may reduce behavioral symptoms in dementia patients, though evidence remains weak due to study…
Higher EAT-Lancet diet adherence linked to lower risks of depression, anxiety, stroke, and dementia in observational cohorts
Eating healthy plant foods may lower risk of depression, anxiety, stroke, and dementia in older adults
This systematic review and meta-analysis examined associations between adherence to the EAT-Lancet diet and neuropsychiatric disorders acros…
A review of many studies found that following a plant-based diet like EAT-Lancet was linked to lower chances of depression, anxiety, stroke,…
Systematic review and meta-analysis of retinal biomarkers in frontotemporal dementia and Alzheimer disease
Retinal scans show thinner layers in frontotemporal dementia than Alzheimer disease
This systematic review and meta-analysis synthesized optical coherence tomography data on retinal biomarkers in frontotemporal dementia, Alz…
A new analysis of retinal scans found that people with frontotemporal dementia have thinner eye layers than those with Alzheimer disease or …
Depression linked to higher risk of progression from mild cognitive impairment to Alzheimer's disease and dementia in adults
Depression Linked to Higher Risk of Dementia Progression in Mild Cognitive Impairment
This systematic review and meta-analysis evaluated the association between depression and progression from mild cognitive impairment to Alzh…
A new analysis suggests depression may increase the risk of dementia progression in adults with mild cognitive impairment, though evidence c…
Meta-analysis of Mendelian randomization suggests GLP-1 receptor agonism lowers vascular dementia risk
Genetic data suggests GLP-1 drugs may lower vascular dementia risk
This meta-analysis of Mendelian randomization studies evaluated the association between GLP-1 receptor agonism and dementia risk using genet…
New genetic evidence hints that GLP-1 receptor agonists might lower the risk of vascular dementia, but results for Alzheimer's disease remai…
Antipsychotic use persists in hospitalized dementia patients despite intervention
Antipsychotics Stay High Despite New Care Plans
This secondary analysis of an RCT examined antipsychotic use in 455 hospitalized older adults with dementia across 12 nursing homes. The int…
Older adults with dementia often leave the hospital on strong drugs that may not help them feel better at home.
Meta-analysis links acute kidney injury to increased stroke, delirium, and dementia risk
Kidney Injury Today Linked to Higher Stroke and Dementia Risk Tomorrow
This systematic review and meta-analysis synthesized data from 11,253,825 participants on associations between acute kidney injury and subse…
New research shows kidney injury dramatically increases later dementia risk even after recovery surprising many who thought kidneys and brai…
Systematic review and meta-analysis of dual-task walking in adults with dementia shows slower speed and shorter steps versus controls
New Walking Tests Reveal Hidden Dementia Signs Before Memory Fails
This systematic review and meta-analysis evaluates instrumented dual-task paradigms versus single-task conditions in adults with clinically …
• Movement changes during thinking tasks signal early dementia • Helps people worried about memory loss get earlier answers • Still needs te…
Questions about Vascular Dementia
Is there a link between schizophrenia and the development of vascular dementia?
People with schizophrenia have a two- to threefold higher risk of developing dementia, including vascular dementia, due to shared biological factors and medical burdens.
Full answer →How do antidiabetic drugs affect dementia risk in patients with diabetes?
Research shows that insulin, metformin, and pioglitazone lower dementia risk compared to placebo, while DPP4 inhibitors may increase vascular dementia risk compared to SGLT2 inhibitors.
Full answer →Does having schizophrenia increase my chances of getting vascular dementia later?
Having schizophrenia increases your risk of developing dementia later in life by about two to three times, and this higher risk includes a specific increase in vascular dementia.
Full answer →