Mesenchymal stromal cells and MSC-derived extracellular vesicles may reprogram neuroimmune responses in neurodegenerative diseases
Stem cells and vesicles show potential for neurodegenerative diseases
This critical review examines the mechanisms and translational barriers of mesenchymal stromal cells (MSCs) and MSC-derived extracellular ve…
New research explores how stem cell products might protect the brain and repair blood-brain barriers in diseases like Parkinson's and Alzhei…
Impact of Domain Specific Physical Activity on Risk of All Cause Dementia
High levels of physical activity linked to lower dementia risk
A massive meta-analysis of over 4 million participants reveals that specific types of physical activity significantly influence dementia ris…
Active lifestyles, especially during leisure time, are linked to a lower risk of developing Alzheimer's and other forms of dementia.
Prolonged FVEP-P2 latency is associated with Alzheimer's disease and other forms of dementia
Brain Signal Delays Linked to Alzheimer's and Dementia Types
This meta-analysis of 18 comparisons involving 1,778 participants found significantly prolonged FVEP-P2 latency in patients with Alzheimer's…
A large review found that specific brain signal delays are linked to Alzheimer's disease and other forms of cognitive decline.
SGLT2 inhibitors significantly reduce dementia risk in patients with type 2 diabetes
Diabetes drugs may lower dementia risk, study finds
This network meta-analysis involving 845,433 participants analyzed the impact of SGLT2 inhibitors on dementia outcomes in patients with type…
A large analysis of over 845,000 people with type 2 diabetes found that certain diabetes drugs, especially empagliflozin, were linked to a l…
Elevated neutrophil-to-lymphocyte ratio correlates with greater cerebral small vessel disease burden and white matter hyperintensities
High Neutrophil Levels Linked to Brain Small Vessel Damage
This systematic review and meta-analysis of 62,961 patients found that elevated neutrophil-to-lymphocyte ratio (NLR) is associated with the …
A large analysis finds that higher neutrophil-to-lymphocyte ratios are linked to more severe damage in the brain's small blood vessels.
Diabetes mellitus acts as a context-dependent modifier of risk and phenotype in neurological disorders
Diabetes May Influence Risk and Progress of Neurological Disorders
This narrative review synthesizes evidence regarding the role of diabetes mellitus (DM) as a disease modifier across various neurological co…
New research suggests that diabetes can change how certain neurological conditions progress, potentially opening doors for new treatment opt…
Ligustilide shows neuroprotective effects across multiple CNS disorders in preclinical models
Ligustilide Shows Potential for Treating Various Brain Disorders
This systematic review of 55 original studies evaluates the neuroprotective potential of ligustilide (LIG) in various neurological condition…
Early research on the compound ligustilide shows potential to protect brain cells from damage caused by stroke, dementia, and other neurolog…
Systematic review finds inflammatory markers elevated in Alzheimer's disease compared to healthy controls across 41 studies
Inflammatory markers linked to Alzheimer's and other dementia types
This systematic review and meta-analysis examined 41 eligible studies involving healthy controls and patients with various dementia subtypes…
A large review found that people with Alzheimer's and other dementias show higher inflammation than healthy people, though more research is …
Meta-analysis suggests high BMI causally increases vascular-related dementia risk via blood pressure mediation
Higher body weight linked to increased risk of vascular dementia
This Mendelian randomization meta-analysis evaluates the causal link between high body mass index and vascular-related dementia. The analysi…
A large genetic study shows that a higher body mass index (BMI) raises the risk of vascular-related dementia. High blood pressure plays a ke…
Bayesian network meta-analysis evaluates antidiabetic medications and dementia risk in 4,382,897 patients
Could diabetes drugs lower dementia risk, or raise it for some patients?
This Bayesian network meta-analysis synthesized data from 28 articles involving 4,382,897 patients to assess antidiabetic drugs and dementia…
Insulin and metformin cut dementia risk, but DPP4 inhibitors may double Alzheimer's risk compared to SGLT2 drugs in diabetes patients.
Mini-review synthesizes dementia risk and cognitive trajectories in individuals with schizophrenia
Do people with schizophrenia face a higher risk of dementia, and what does that mean for their care?
This mini-review examines the relationship between schizophrenia and dementia, covering Alzheimer's disease, vascular dementia, and other fo…
People with schizophrenia face a two- to threefold higher risk of dementia, but it's not a direct path to Alzheimer's—brain development, agi…
Body weight variability associated with increased dementia risk in meta-analysis of cohort studies
Large weight fluctuations linked to higher dementia risk in research review
A systematic review and meta-analysis of 16 cohort studies found that highest levels of body weight fluctuation were associated with increas…
Large swings in body weight are linked to a higher risk of dementia, including Alzheimer's and vascular types, but not general cognitive dec…
Research across Dementia
Related studies from across the Dementia family.
Higher GrimAge epigenetic age acceleration is significantly associated with higher dementia risk
GrimAge metric shows link to increased risk of dementia
This meta-analysis of 46,365 individuals with neurodegenerative diseases found that only the GrimAge metric showed a significant association…
One specific biological age clock, known as GrimAge, showed a link to higher dementia risk in a large study of over 46,000 people.
Social isolation and loneliness are significant determinants of cognitive decline and dementia risk in older adults
Social isolation and loneliness increase risk of dementia in older adults
This systematic review examines the impact of social isolation and loneliness on cognitive decline and dementia risk in older adults. The au…
Loneliness and social isolation are linked to faster cognitive decline and a higher risk of dementia in older adults.
Chronic pain is associated with poorer executive functioning and processing speed in dementia patients
Chronic pain is linked to poorer thinking in people with dementia
This systematic scoping review explores the relationship between chronic pain and cognitive performance in individuals with dementia. The re…
Living with chronic pain may make it harder for people with dementia to manage tasks and process information quickly.
HMB and vitamin D enriched protein supplements may support muscle and cognitive health in dementia
Nutrition Drink May Help Muscles In Dementia Patients
This narrative review examines the role of high protein oral nutritional supplements enriched with HMB and vitamin D for older adults at ris…
A high protein drink with HMB and vitamin D may support muscle health in older adults with dementia, but brain benefits remain unproven.
HMGB1 acts as a progression-associated inflammatory amplifier in Alzheimer's, Parkinson's, and ALS models
New research explores a protein linked to several brain diseases
This narrative review explores the role of HMGB1 in various neurodegenerative diseases including Alzheimer's, Parkinson's, and ALS. The auth…
A specific protein called HMGB1 may act as a driver of inflammation in conditions like Alzheimer's and Parkinson's disease.
HRSN assessment tools lack sufficient psychometric testing and reliability data for geriatric populations
New Review Highlights Gaps in Alzheimer's and Dementia Care Tools
This systematic review of 7 studies evaluated the methodological rigor and psychometric properties of HRSN assessment tools in older adults.…
Current tools used to measure social needs for seniors with dementia lack enough testing to ensure they are accurate for older adults.
Scoping review protocol to map living arrangement and carer variables in dementia help-seeking research
Mapping How Living Arrangements Affect Help Seeking for Dementia
This is a scoping review protocol, not a completed study, that will map how living arrangement and supporter or carer related variables are …
New research plans to map how living situations and family support impact how people with memory problems seek a diagnosis for dementia.
Impact of Receptor Stimulating Antihypertensive Medications on Alzheimer Disease Risk in Elderly Patients
Certain blood pressure medications may link to lower dementia risk
Retrospective analysis suggests receptor-stimulating antihypertensives may correlate with lower ADRD incidence compared to receptor-inhibiti…
A large study of over 1.5 million seniors suggests specific blood pressure medications may be linked to lower rates of dementia and cognitiv…
Comprehensive dementia care interventions improve caregiver self-efficacy in those with lower baseline scores
Comprehensive Care Programs May Improve Confidence for Dementia Caregivers
This secondary analysis of a randomized pragmatic clinical trial involved 2037 caregivers of community-dwelling persons living with dementia…
Caregivers of people with dementia can improve their self-efficacy and confidence through comprehensive care programs.
Non-pharmacological interventions for sleep disturbances in mild cognitive impairment and early dementia provide management guidance
Sleep Care Plan for Early Dementia: Best Evidence
This integrative review and guideline identifies 44 evidence items across 11 themes for managing sleep disturbances in patients with mild co…
A new review maps 44 best evidence items for managing sleep problems in mild cognitive impairment and early dementia.
Increased Risk of Dementia Diagnosis Among Individuals Diagnosed With Bipolar Disorder
Bipolar disorder linked to triple dementia risk
A large-scale meta-analysis identifies a significant correlation between bipolar disorder and an elevated risk of dementia diagnosis.
People with bipolar disorder face a higher risk of dementia, a new analysis finds. The link is strong but the evidence has limits.
Dementia prevalence 24.3% in older adults with psychotic disorders, meta-analysis finds
Dementia found in 1 in 4 older adults with psychotic disorders
This meta-analysis of older adults with psychotic disorders reports a pooled dementia prevalence of 24.3% (95% CI: 20.5%-28.5%), with high h…
A new analysis finds dementia in 24.3% of older adults with psychotic disorders, highlighting the need for better care planning.
Questions about Vascular Dementia
Is there a link between schizophrenia and the development of vascular dementia?
People with schizophrenia have a two- to threefold higher risk of developing dementia, including vascular dementia, due to shared biological factors and medical burdens.
Full answer →How do antidiabetic drugs affect dementia risk in patients with diabetes?
Research shows that insulin, metformin, and pioglitazone lower dementia risk compared to placebo, while DPP4 inhibitors may increase vascular dementia risk compared to SGLT2 inhibitors.
Full answer →Does having schizophrenia increase my chances of getting vascular dementia later?
Having schizophrenia increases your risk of developing dementia later in life by about two to three times, and this higher risk includes a specific increase in vascular dementia.
Full answer →