Impact of Domain Specific Physical Activity on Risk of All Cause Dementia
High levels of physical activity linked to lower dementia risk
A massive meta-analysis of over 4 million participants reveals that specific types of physical activity significantly influence dementia ris…
Active lifestyles, especially during leisure time, are linked to a lower risk of developing Alzheimer's and other forms of dementia.
Prolonged FVEP-P2 latency is associated with Alzheimer's disease and other forms of dementia
Brain Signal Delays Linked to Alzheimer's and Dementia Types
This meta-analysis of 18 comparisons involving 1,778 participants found significantly prolonged FVEP-P2 latency in patients with Alzheimer's…
A large review found that specific brain signal delays are linked to Alzheimer's disease and other forms of cognitive decline.
SGLT2 inhibitors significantly reduce dementia risk in patients with type 2 diabetes
Diabetes drugs may lower dementia risk, study finds
This network meta-analysis involving 845,433 participants analyzed the impact of SGLT2 inhibitors on dementia outcomes in patients with type…
A large analysis of over 845,000 people with type 2 diabetes found that certain diabetes drugs, especially empagliflozin, were linked to a l…
Elevated neutrophil-to-lymphocyte ratio correlates with greater cerebral small vessel disease burden and white matter hyperintensities
High Neutrophil Levels Linked to Brain Small Vessel Damage
This systematic review and meta-analysis of 62,961 patients found that elevated neutrophil-to-lymphocyte ratio (NLR) is associated with the …
A large analysis finds that higher neutrophil-to-lymphocyte ratios are linked to more severe damage in the brain's small blood vessels.
Diabetes mellitus acts as a context-dependent modifier of risk and phenotype in neurological disorders
Diabetes May Influence Risk and Progress of Neurological Disorders
This narrative review synthesizes evidence regarding the role of diabetes mellitus (DM) as a disease modifier across various neurological co…
New research suggests that diabetes can change how certain neurological conditions progress, potentially opening doors for new treatment opt…
Ligustilide shows neuroprotective effects across multiple CNS disorders in preclinical models
Ligustilide Shows Potential for Treating Various Brain Disorders
This systematic review of 55 original studies evaluates the neuroprotective potential of ligustilide (LIG) in various neurological condition…
Early research on the compound ligustilide shows potential to protect brain cells from damage caused by stroke, dementia, and other neurolog…
Systematic review finds inflammatory markers elevated in Alzheimer's disease compared to healthy controls across 41 studies
Inflammatory markers linked to Alzheimer's and other dementia types
This systematic review and meta-analysis examined 41 eligible studies involving healthy controls and patients with various dementia subtypes…
A large review found that people with Alzheimer's and other dementias show higher inflammation than healthy people, though more research is …
Meta-analysis suggests high BMI causally increases vascular-related dementia risk via blood pressure mediation
Higher body weight linked to increased risk of vascular dementia
This Mendelian randomization meta-analysis evaluates the causal link between high body mass index and vascular-related dementia. The analysi…
A large genetic study shows that a higher body mass index (BMI) raises the risk of vascular-related dementia. High blood pressure plays a ke…
Bayesian network meta-analysis evaluates antidiabetic medications and dementia risk in 4,382,897 patients
Could diabetes drugs lower dementia risk, or raise it for some patients?
This Bayesian network meta-analysis synthesized data from 28 articles involving 4,382,897 patients to assess antidiabetic drugs and dementia…
Insulin and metformin cut dementia risk, but DPP4 inhibitors may double Alzheimer's risk compared to SGLT2 drugs in diabetes patients.
Mini-review synthesizes dementia risk and cognitive trajectories in individuals with schizophrenia
Do people with schizophrenia face a higher risk of dementia, and what does that mean for their care?
This mini-review examines the relationship between schizophrenia and dementia, covering Alzheimer's disease, vascular dementia, and other fo…
People with schizophrenia face a two- to threefold higher risk of dementia, but it's not a direct path to Alzheimer's—brain development, agi…
Body weight variability associated with increased dementia risk in meta-analysis of cohort studies
Large weight fluctuations linked to higher dementia risk in research review
A systematic review and meta-analysis of 16 cohort studies found that highest levels of body weight fluctuation were associated with increas…
Large swings in body weight are linked to a higher risk of dementia, including Alzheimer's and vascular types, but not general cognitive dec…
Research across Dementia
Related studies from across the Dementia family.
Comprehensive dementia care interventions improve caregiver self-efficacy in those with lower baseline scores
Comprehensive Care Programs May Improve Confidence for Dementia Caregivers
This secondary analysis of a randomized pragmatic clinical trial involved 2037 caregivers of community-dwelling persons living with dementia…
Caregivers of people with dementia can improve their self-efficacy and confidence through comprehensive care programs.
Non-pharmacological interventions for sleep disturbances in mild cognitive impairment and early dementia provide management guidance
Sleep Care Plan for Early Dementia: Best Evidence
This integrative review and guideline identifies 44 evidence items across 11 themes for managing sleep disturbances in patients with mild co…
A new review maps 44 best evidence items for managing sleep problems in mild cognitive impairment and early dementia.
Increased Risk of Dementia Diagnosis Among Individuals Diagnosed With Bipolar Disorder
Bipolar disorder linked to triple dementia risk
A large-scale meta-analysis identifies a significant correlation between bipolar disorder and an elevated risk of dementia diagnosis.
People with bipolar disorder face a higher risk of dementia, a new analysis finds. The link is strong but the evidence has limits.
Dementia prevalence 24.3% in older adults with psychotic disorders, meta-analysis finds
Dementia found in 1 in 4 older adults with psychotic disorders
This meta-analysis of older adults with psychotic disorders reports a pooled dementia prevalence of 24.3% (95% CI: 20.5%-28.5%), with high h…
A new analysis finds dementia in 24.3% of older adults with psychotic disorders, highlighting the need for better care planning.
Animal-assisted interventions improve depression in dementia, but not other outcomes
Animal interactions may help ease depression in people with dementia
This overview of systematic reviews and meta-analyses found moderate evidence that animal-assisted interventions (AAIs) improve depression i…
Interacting with animals can significantly improve feelings of depression for people living with dementia, according to a review of recent r…
Person-centered non-pharmacological interventions significantly reduce verbal agitation in patients with dementia
Personalized care helps reduce agitation in people with dementia
This meta-analysis of randomized controlled trials evaluates the impact of person-centered non-pharmacological interventions on agitation in…
Tailored, person-centered care can significantly lower verbal agitation in people living with dementia compared to standard methods.
Gabapentinoid use is associated with modestly higher odds of Alzheimer's disease and related dementias
Reviewing the Link Between Gabapentin Use and Risk of Developing Dementia
This meta-analysis of 325,245 individuals found that gabapentinoid use was associated with modestly higher odds of Alzheimer's disease and r…
A large review looked at how gabapentin and pregabalin affect brain health. Some findings suggest a possible link to dementia.
Diabetic retinopathy is associated with a significantly higher risk of all-cause dementia
Diabetic retinopathy is linked to a higher risk of dementia
This meta-analysis of observational studies involving 2,887,409 patients found that diabetic retinopathy is associated with an increased ris…
A large analysis shows people with diabetic retinopathy may face an increased risk of developing dementia, highlighting the need for closer …
Pain assessment guidelines for cognitively impaired older adults lack practical detail
Pain guidelines for dementia patients lack practical advice
This scoping review mapped pain assessment guidelines for hospitalized older adults with cognitive impairment. No Australian guidelines were…
A review finds most pain assessment guidelines for older adults with dementia offer little practical help for hospital staff.
Network meta-analysis protocol aims to rank structured exercise interventions for fall prevention in dementia
Exercise Programs May Help Prevent Falls in Seniors with Dementia
This is a protocol for a systematic review and network meta-analysis regarding structured exercise interventions for older adults with mild …
A planned review aims to determine which types of structured exercise best help older adults with memory loss stay safe and avoid falling.
Multidomain lifestyle interventions provide small but statistically significant benefits for global cognition scores
Multidomain lifestyle changes may help slow signs of dementia
This meta-analysis of randomized controlled trials involving 23209 participants found that multidomain lifestyle interventions (three or mor…
Combining multiple lifestyle habits like diet and exercise can lead to small but steady improvements in brain health for those at risk of de…
TBP expansion in SCA17 can cause dementia-like symptoms and requires etiological reconsideration
New Diagnosis for Dementia Patients with Spinocerebellar Ataxia Type 17
This case report and focused literature review describes a patient with SCA17 presenting as dementia, highlighting the need for genetic test…
A new look at dementia cases may reveal an underlying genetic condition called spinocerebellar ataxia type 17.
Questions about Vascular Dementia
Is there a link between schizophrenia and the development of vascular dementia?
People with schizophrenia have a two- to threefold higher risk of developing dementia, including vascular dementia, due to shared biological factors and medical burdens.
Full answer →How do antidiabetic drugs affect dementia risk in patients with diabetes?
Research shows that insulin, metformin, and pioglitazone lower dementia risk compared to placebo, while DPP4 inhibitors may increase vascular dementia risk compared to SGLT2 inhibitors.
Full answer →Does having schizophrenia increase my chances of getting vascular dementia later?
Having schizophrenia increases your risk of developing dementia later in life by about two to three times, and this higher risk includes a specific increase in vascular dementia.
Full answer →