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Home › Conditions › Venous Thromboembolism

Venous Thromboembolism

Part of Embolism and Thrombosis

13 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Venous Thromboembolism

84 trials tracked for Venous Thromboembolism: 31 in phase 3 or 4 and 14 with published results. The most-cited published study has 1028 citations.

84Trials tracked
31Phase 3 & 4
0Recruiting
14With published results
Phase distribution
Phase 4 9 Phase 3 22 Phase 2 20 Phase 1 5 Other / NA 28
  1. Phase 3 Apixaban for the Treatment of Venous Thromboembolism in Patients With Cancer Completed · 1,028 cited
  2. Phase 3 Reduced-dosed Rivaroxaban in the Long-term Prevention of Recurrent Symptomatic VTE(Venous Thromboembolism) Completed · 764 cited
  3. Phase 3 Apixaban or Dalteparin in Reducing Blood Clots in Patients With Cancer Related Venous Thromboembolism Completed · 576 cited
  4. Phase 3 EINSTEIN Junior: Oral Rivaroxaban in Children With Venous Thrombosis Completed · 314 cited
  5. Phase 3 Open Label Study Comparing Efficacy and Safety of Dabigatran Etexilate to Standard of Care in Paediatric Patients With Venous Thromboembolism (VTE) Completed · 149 cited
  6. Phase 3 Safety of Dabigatran Etexilate in Blood Clot Prevention in Children Completed · 93 cited
Show 44 more trials
  1. Phase 3 Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis Completed · 86 cited
  2. Phase 3 PROSPER: PostpaRtum PrOphylaxiS for PE Randomized Control Trial Pilot Completed · 83 cited
  3. Phase 4 Prevention of Arteriovenous Thrombotic Events in Critically-Ill COVID-19 Patients Trial Completed · 82 cited
  4. Phase 4 Dalteparin for Primary Venous Thromboembolism (VTE) Prophylaxis in Pancreatic Cancer Patients Completed · 63 cited
  5. Phase 3 Prospective Study on Preoperative Versus Postoperative Venous Thromboprophylaxis in Patients Undergoing Major Colorectal Surgery Completed · 36 cited
  6. Phase 4 Extended-Duration Low-Intensity Apixaban to Prevent Recurrence in High-Risk Patients With Provoked Venous Thromboembolism Completed · 28 cited
  7. Phase 4 Apixaban for Primary Prevention of Venous Thromboembolism in Patients With Multiple Myeloma Completed · 15 cited
  8. Phase 4 Evaluation of Venous Thromboembolism Prevention in High-Risk Trauma Patients Completed · 8 cited
  9. Phase 4 Aspirin for Prevention of Venous Thromboembolism Among Ovarian Cancer Patients Receiving Neoadjuvant Chemotherapy Completed
  10. Phase 4 Use of Tranexamic Acid in Reduction Mammoplasty Completed
  11. Phase 4 Apixaban for the Acute Treatment of Venous Thromboembolism in Children Completed
  12. Phase 4 Fondaparinux in Critically Ill Patients With Renal Failure Completed
  13. Phase 3 A Different Approach to Preventing Thrombosis Completed
  14. Phase 3 RAMBLE - Rivaroxaban vs. Apixaban for Heavy Menstrual Bleeding Completed
  15. Phase 3 Regulation of Coagulation in Orthopedic Surgery to Prevent Deep Vein Thromboembolism (DVT) and Pulmonary Embolism (PE). A Study of BAY59-7939 in the Prevention of Venous Thrombo Embolism (VTE) in Subjects Undergoing Elective Total Knee Replacement. Completed
  16. Phase 3 Comparative Investigation of Low Molecular Weight (LMW) Heparin/Edoxaban Tosylate (DU176b) Versus (LMW) Heparin/Warfarin in the Treatment of Symptomatic Deep-Vein Blood Clots and/or Lung Blood Clots. (The Edoxaban Hokusai-VTE Study). Completed
  17. Phase 3 A Phase 3 Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Knee Arthroplasty Completed
  18. Phase 3 Twice-daily Oral Direct Thrombin Inhibitor Dabigatran Etexilate in the Long Term Prevention of Recurrent Symptomatic VTE Completed
  19. Phase 3 A Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Hip Arthroplasty Completed
  20. Phase 3 Dabigatran Etexilate Compared With Enoxaparin in Prevention of Venous Thromboembolism (VTE) Following Total Hip Arthroplasty Completed
  21. Phase 3 Once - Daily Oral Direct Factor Xa Inhibitor Rivaroxaban In The Long-Term Prevention Of Recurrent Symptomatic Venous Thromboembolism In Patients With Symptomatic Deep-Vein Thrombosis Or Pulmonary Embolism. The Einstein-Extension Study Completed
  22. Phase 3 Venous Thromboembolic Event (VTE) Prophylaxis in Medically Ill Patients Completed
  23. Phase 3 The Use of Fondaparinux in Preventing Thromboembolism in High Risk Trauma Patients Completed
  24. Phase 3 Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Hip Fracture Surgery Completed
  25. Phase 3 Safety and Pharmacokinetics Study of DU-176b Administered to Patients With Severe Renal Impairment Undergoing Orthopedic Surgery of The Lower Limbs Completed
  26. Phase 2 Weight-Based Enoxaparin Dosing and Real-Time Dose Adjustment in Orthopaedic Trauma Completed
  27. Phase 2 Apixaban vs Enoxaparin Following Microsurgical Breast Reconstruction-An RCT Completed
  28. Phase 2 Prothrombin Times Outside the Therapeutic Range in Otherwise Stable Patients Completed
  29. Phase 2 Fixed Versus Weight-Based Enoxaparin Dosing in Thoracic Surgery Patients Completed
  30. Phase 2 A Trial to Learn How Well REGN7508 Works for Preventing Blood Clots After a Knee Replacement in Adult Participants Completed
  31. Phase 2 Safety and Tolerability of Dabigatran Etexilate Solution in Children 1 to < 12 Years of Age Completed
  32. Phase 2 BIBR 1048 Dose Range Finding Study in Prevention of Venous Thromboembolism in Patients With Primary Elective Total Hip or Knee Replacement Surgery Completed
  33. Phase 2 Fragmin for the Treatment of Acute VTE in Pediatric Cancer Patients Completed
  34. Phase 2 Minimization of Bleeding Related Adverse Drug Events in Plastic & Reconstructive Surgery Completed
  35. Phase 2 Oral Apixaban (Eliquis) Versus Enoxaparin (Lovenox) for Thromboprophylaxis in Women With Suspected Pelvic Malignancy Completed
  36. Phase 2 Tolerability , PK/PD and Safety of Dabigatran Etexilate Oral Liquid Formulation in Children < 1 Year of Age Completed
  37. Phase 2 A Phase 2b Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Hip Arthroplasty Completed
  38. Phase 2 A Phase 2b Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Knee Arthroplasty Completed
  39. Phase 2 Safety and Tolerability of Dabigatran Etexilate in Adolescents Completed
  40. Phase 2 EINSTEIN Junior Phase II: Oral Rivaroxaban in Young Children With Venous Thrombosis Completed
  41. Phase 2 A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult Participants Completed
  42. Phase 2 Enoxaparin Metabolism in Reconstructive Surgery Patients Completed
  43. Phase 2 Efficacy of RIvaroxaban for Prevention of Venous Thromboembolism After Knee Arthroscopy Completed
  44. Phase 2 Odiparcil For The Prevention Of Venous Thromboembolism Completed

Showing the 50 most-cited and recently-updated of 84 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
LMWH remains useful when oral anticoagulants are difficult to use safely in venous thromboembolism patients
Drug Pipeline Sys. Review
LMWH remains useful when oral anticoagulants are difficult to use safely in venous thromboembolism patients Low-molecular-weight heparin remains useful when oral anticoagulants are difficult to use safely
This narrative review examines low-molecular-weight heparin dosing, anti-factor Xa monitoring, treatment interruption, and switching strateg…
A review suggests low-molecular-weight heparin stays useful when oral anticoagulants are difficult to use safely for patients with venous th…
Frontiers Jun 5, 2026
Pre-infection vaccination linked to lower cardiovascular and cerebrovascular event risks in SARS-CoV-2 infected individuals
Infectious Disease Sys. Review
Pre-infection vaccination linked to lower cardiovascular and cerebrovascular event risks in SARS-CoV-2 infected individuals Vaccination Before Infection Cuts Heart and Stroke Risks in COVID Patients
This systematic review and meta-analysis examined the association between pre-infection COVID-19 vaccination and cardiovascular outcomes in …
Pre-infection COVID-19 vaccination significantly lowers risks of heart attacks, strokes, and other cardiovascular events in infected individ…
medRxiv May 23, 2026
Postoperative VTE prediction models show substantial heterogeneity and high bias risk in lung cancer surgery patients undergoing systematic review analysis
Oncology Meta-analysis
Postoperative VTE prediction models show substantial heterogeneity and high bias risk in lung cancer surgery patients undergoing systematic review analysis Existing lung cancer VTE prediction models show mixed results in surgery patients
A systematic review of twenty prediction models for venous thromboembolism in lung cancer surgery patients revealed substantial heterogeneit…
A review of twenty studies found that current tools for predicting blood clots in lung cancer surgery patients vary widely in accuracy and c…
Frontiers May 20, 2026
Network meta-analysis compares DOACs and VKAs for intracranial hemorrhage risk
Cardiology Meta-analysis
Network meta-analysis compares DOACs and VKAs for intracranial hemorrhage risk Dabigatran may be safest for brain bleeding risk
This network meta-analysis of 127,267 patients with venous thromboembolism or atrial fibrillation found that all DOACs had lower risk of int…
All blood thinners beat warfarin for brain bleed risk, but dabigatran may be the safest choice.
Frontiers May 19, 2026
Systematic review and meta-analysis links D-dimer and ultrasound findings to recurrent venous thromboembolism risk
Radiology & Imaging Meta-analysis
Systematic review and meta-analysis links D-dimer and ultrasound findings to recurrent venous thromboembolism risk Doctors find high D-dimer levels and ultrasound results predict higher risk of blood clot return
This systematic review and meta-analysis of 48 articles evaluates the association between residual vein thrombosis and positive post-treatme…
A review of many studies shows that leftover blood clots and high D-dimer levels after treatment raise the chance of venous thromboembolism …
May 16, 2026
Subprophylactic anti-Xa levels linked to higher venous thromboembolism risk in critically ill adults receiving low-molecular-weight heparin
Emergency Medicine Meta-analysis
Subprophylactic anti-Xa levels linked to higher venous thromboembolism risk in critically ill adults receiving low-molecular-weight heparin Low blood clot prevention drug levels linked to higher risk in sick adults
A systematic review and meta-analysis of 7,124 critically ill adults reveals that 47% failed to achieve target anti-Xa levels. Subprophylact…
A large review found that nearly half of critically ill adults did not reach safe drug levels. Those with lower levels faced a much higher c…
May 6, 2026
Meta-analysis identifies prognostic factors for recurrent VTE and bleeding in 96 753 adult cancer patients
Oncology Meta-analysis
Meta-analysis identifies prognostic factors for recurrent VTE and bleeding in 96 753 adult cancer patients Certain cancer types and health factors raise risk of blood clots or bleeding in adults with cancer and VTE
This meta-analysis evaluated prognostic factors for recurrent venous thromboembolism (VTE) or anticoagulant-related bleeding in 96 753 adult…
A large review found that specific cancers and health factors significantly increase the risk of recurrent blood clots or bleeding in adults…
Apr 23, 2026
Systematic review and meta-analysis finds high VTE incidence in stroke patients and moderate model performance
Cardiology Meta-analysis
Systematic review and meta-analysis finds high VTE incidence in stroke patients and moderate model performance Doctors Rethink How to Spot Blood Clots in Stroke Patients
This systematic review and meta-analysis of seven prediction models found a pooled VTE incidence of 20.8% in stroke patients.
It starts with a small ache in the leg. A little swelling.
Frontiers Apr 23, 2026
Inflammatory and cardiac markers linked to VTE and bleeding risks in cancer patients on apixaban
Oncology RCT
Inflammatory and cardiac markers linked to VTE and bleeding risks in cancer patients on apixaban New Blood Tests May Predict Clot and Bleed Risks in Cancer
A post hoc analysis of an RCT in 574 ambulatory cancer patients with a Khorana score ≥2 found that elevated baseline growth differentiation …
Scientists found specific blood markers that signal higher risks of clots and bleeding in cancer patients.
Apr 22, 2026
Meta-analysis finds increased VTE risk in pediatric IBD, especially ulcerative colitis
Pediatrics Meta-analysis
Meta-analysis finds increased VTE risk in pediatric IBD, especially ulcerative colitis Kids with Bowel Disease Face a Hidden Blood Clot Risk Adults Miss
A systematic review and meta-analysis of over 100,000 children and teenagers with IBD found a significantly increased risk of venous thrombo…
Children with Crohn's or ulcerative colitis face nearly seven times the blood clot risk of healthy kids, yet prevention guidelines for teens…
Apr 14, 2026
Early LMWH prophylaxis in surgical patients with severe hypertensive intracerebral hemorrhage
Neurology Cohort
Early LMWH prophylaxis in surgical patients with severe hypertensive intracerebral hemorrhage The Blood Thinner Timing Puzzle After a Brain Bleed
This retrospective cohort study evaluated early low-molecular-weight heparin calcium prophylaxis for venous thromboembolism in 123 surgical …
After brain bleed surgery, doctors face a tough choice — start blood thinners early to prevent leg clots, or wait and risk a dangerous clot …
Frontiers Apr 13, 2026
Asthma associated with increased odds of venous thromboembolism, pulmonary embolism, and deep vein thrombosis in observational studies
Allergy & Immunology Meta-analysis
Asthma associated with increased odds of venous thromboembolism, pulmonary embolism, and deep vein thrombosis in observational studies Asthma Linked to Higher Risk of Blood Clots in Observational Data
This meta-analysis of observational studies involving patients with asthma found a statistically significant association between asthma and …
People with asthma face a 1.61 times higher risk of blood clots, with the danger of pulmonary embolism rising 2.41 times and deep vein throm…
Apr 9, 2026

Research across Embolism and Thrombosis

Related studies from across the Embolism and Thrombosis family.

DOACs reduce thromboembolic events in pediatric patients compared to standard anticoagulation
Infectious Disease Meta-analysis
DOACs reduce thromboembolic events in pediatric patients compared to standard anticoagulation A Pill Form of Blood Thinner May Be Safer for Kids Than Standard Shots
A meta-analysis of 2,002 pediatric patients found direct oral anticoagulants (DOACs) significantly reduced thromboembolic event recurrence (…
New oral blood thinners cut dangerous blood clot recurrences in half for children without increasing bleeding risks compared to standard sho…
Frontiers Apr 13, 2026

Questions about Venous Thromboembolism

Does having asthma increase my odds of developing venous thromboembolism or deep vein thrombosis?

Yes, asthma is linked to higher odds of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE).

Full answer →
What factors predict a recurrence of venous thromboembolism or bleeding in adult cancer patients?

In adult cancer patients, prior VTE, poor performance status, advanced cancer, and certain tumor sites (lung, pancreas, hepatobiliary, genitourinary) predict higher recurrence risk; elevated biomarkers like growth differentiation factor-15 also raise risk.

Full answer →

All Venous Thromboembolism Articles