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Home › Medications › bupivacaine

bupivacaine

6 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of bupivacaine

109 trials tracked of bupivacaine: 76 in phase 3 or 4 and 26 with published results. The most-cited published study has 158 citations.

109Trials tracked
76Phase 3 & 4
0Recruiting
26With published results
Phase distribution
Phase 4 59 Phase 3 17 Phase 2 14 Phase 1 2 Other / NA 17
  1. Phase 4 Local Infiltration Analgesia With and Without EXPAREL Following Total Knee Arthroplasty Completed · 158 cited
  2. Phase 4 Evaluate the Safety and Efficacy of EXPAREL When Administered Via Infiltration Into the TAP vs. Bupivacaine Alone in Subjects Undergoing Elective C-Sections Completed · 111 cited
  3. Phase 4 Single Injection Adductor Canal Block vs Catheter for Total Knee Arthroplasty Completed · 75 cited
  4. Phase 3 Bunionectomy Study for Postoperative Analgesia (EPOCH 1) Completed · 52 cited
  5. Phase 4 The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery Completed · 36 cited
  6. Phase 4 Fascia Iliaca Blocks for Pain Control After Total Hip Arthroplasty Completed · 34 cited
Show 44 more trials
  1. Phase 4 PAIN - Postoperative Analgesia INvestigation Completed · 34 cited
  2. Phase 4 Interscalene Block With Low-dose IV vs. Perineural Dexamethasone for Shoulder Arthroscopy Completed · 33 cited
  3. Phase 4 Improvement of Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse Completed · 32 cited
  4. Phase 4 Mixture of Liposomal Bupivacaine and Bupivacaine for TAP Block for Open Hysterectomy Completed · 26 cited
  5. Phase 4 Liposomal Bupivacaine Interscalene Blocks for Rotator Cuff Repair Completed · 23 cited
  6. Phase 4 The Effect of Liposomal Bupivacaine on Post Operative Pain and Narcotic Use After Bariatric Surgery Completed · 22 cited
  7. Phase 4 Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal) Completed · 21 cited
  8. Phase 3 Para-cervical Block Prior to Laparoscopic Hysterectomy as an Adjuvant Treatment to Reduce Postoperative Pain. Completed · 18 cited
  9. Phase 3 Phase 3, Sciatic Nerve Block With EXPAREL for Subjects Undergoing Bunionectomy Completed · 18 cited
  10. Phase 4 Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain Completed · 15 cited
  11. Phase 4 Perineural Steroids for Peripheral Nerve Blocks Completed · 14 cited
  12. Phase 4 Determining the Prognostic Value of Continuous Intrathecal Infusion Completed · 11 cited
  13. Phase 4 Systemic Steroids for Peripheral Nerve Blocks Completed · 11 cited
  14. Phase 4 Obstetric Liposomal Bupivacaine Via Surgical Transversus Abdominis Plane Block for Post Cesarean Pain Control Completed · 11 cited
  15. Phase 3 Phase 3 Herniorrhaphy Study for Postoperative Analgesia (EPOCH 2) Completed · 9 cited
  16. Phase 4 Efficacy of Ipack Block and Surgeon's Joint Infiltration in Total Knee Arthroplasty Completed · 8 cited
  17. Phase 3 Comparing Liposomal Bupivacaine Versus Standard Bupivacaine in Colorectal Surgery Completed · 7 cited
  18. Phase 4 ED90 for Hyperbaric Bupivacaine in Super Obese Parturients Completed · 6 cited
  19. Phase 4 ESP Block for Post Cesarean Analgesia Completed · 2 cited
  20. Phase 3 Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty Completed
  21. Phase 4 Ultrasound-guided Adductor Canal Block for Total Knee Replacement Completed
  22. Phase 4 Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain Completed
  23. Phase 4 The Effects of Scalp Block With Bupivacaine Versus Levobupivacaine Completed
  24. Phase 4 Continuous Adductor Canal Blocks Vs. Low Dose Femoral Nerve Blocks For Early Rehabilitation After Total Knee Arthroplasty Completed
  25. Phase 4 Liposomal Bupivacaine for Post Operative Pain After Knee Replacement Surgery Completed
  26. Phase 4 Parasternal Nerve Block Using Bupivacaine for Postoperative Analgesia in Children Undergoing Cardiac Surgery Completed
  27. Phase 4 TAP vs Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic Hysterectomy Completed
  28. Phase 4 The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI) Completed
  29. Phase 4 Adductor Canal Block Versus Periarticular Bupivicaine Injection in Total Knee Arthroplasty Completed
  30. Phase 4 A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty Completed
  31. Phase 4 Interscalene Block Versus Superior Trunk Block Completed
  32. Phase 4 Programmed Intermittent Bolus Dosing Versus Continuous Epidural Infusion for Epidural Analgesia in Abdominal Surgery. Completed
  33. Phase 4 Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage Completed
  34. Phase 4 Randomized Trial of Wound Infiltration With Extended-release Bupivacaine Before Laparoscopic or Robotic Hysterectomy Completed
  35. Phase 4 Liposomal Bupivacaine Interscalene Nerve Block in Shoulder Arthroplasty Completed
  36. Phase 4 Sphenopalatine Ganglion Blocks RCT Completed
  37. Phase 4 Patient Controlled Intrathecal Analgesia With Bupivacaine for Chronic Low Back Pain Completed
  38. Phase 4 A Novel Analgesia Technique for ACL Reconstruction Completed
  39. Phase 4 Efficacy of Exparel (TM) on Post-operative Pain After Laparoscopic Gastric Bypass Using Circular EEA Stapler Completed
  40. Phase 4 Efficacy of Liposomal Bupivacaine for Prolonged Postoperative Analgesia in Patient Undergoing Breast Reconstruction With Tissue Expander Completed
  41. Phase 4 Minimal Opioid Use After Total Hip Replacement (THR) Completed
  42. Phase 4 Regional Anesthesia to Reduce Opioid Use Following Functional Endoscopic Sinus Surgery Completed
  43. Phase 4 Unilateral TAP Block for Laparoscopic Gastric Sleeve Surgery Completed
  44. Phase 4 The Use Of Liposomal Bupivacaine For Pain Control Completed

Showing the 50 most-cited and recently-updated of 109 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Liposomal bupivacaine reduces 24-hour resting pain scores by 1.04 points in brachial plexus blocks
Anesthesiology & Pain Medicine Meta-analysis
Liposomal bupivacaine reduces 24-hour resting pain scores by 1.04 points in brachial plexus blocks Liposomal bupivacaine reduces pain after upper limb surgery
This meta-analysis of trials involving patients undergoing upper limb surgery found that liposomal bupivacaine significantly reduced resting…
A new type of local anesthetic may lower pain scores and reduce opioid use for patients undergoing upper limb surgeries.
Jun 11, 2026
Meta-analysis finds minimal benefit of liposomal bupivacaine in TAP blocks for postoperative pain
Orthopedics & Sports Medicine Meta-analysis
Meta-analysis finds minimal benefit of liposomal bupivacaine in TAP blocks for postoperative pain Liposomal bupivacaine shows minimal benefit for postoperative pain
This meta-analysis of 1528 patients compared liposomal bupivacaine to standard bupivacaine in transversus abdominis plane blocks for postope…
A review of 1,528 patients found liposomal bupivacaine in TAP blocks offers only small reductions in pain and opioid use after surgery.
Frontiers May 20, 2026
Narrative synthesis on liposomal bupivacaine for autologous breast reconstruction pain
Anesthesiology & Pain Medicine Meta-analysis
Narrative synthesis on liposomal bupivacaine for autologous breast reconstruction pain New Pain Strategy Cuts Opioid Use After Breast Surgery
This narrative synthesis reviews evidence on liposomal bupivacaine for autologous breast reconstruction. It finds some studies show reduced …
• May reduce opioid use by 20-30% in some cases • Helps women after breast reconstruction surgery • Works best with specific pain plans, not
Frontiers May 12, 2026
Adding adrenaline to bupivacaine for lipoma plane block reduces blood loss and pain
Oncology RCT
Adding adrenaline to bupivacaine for lipoma plane block reduces blood loss and pain Adrenaline in local blocks reduces pain and bleeding during lipoma surgery
This prospective randomized trial in 40 adults undergoing lipoma excision found that adding adrenaline (1:200,000) to bupivacaine for ultras…
Adding adrenaline to a local anesthetic block lessened pain and bleeding for patients having lipoma removal, based on a trial of 40 adults.
May 1, 2026
PENG block with bupivacaine reduces early POCD incidence after hip arthroplasty in older patients
Anesthesiology & Pain Medicine RCT
PENG block with bupivacaine reduces early POCD incidence after hip arthroplasty in older patients PENG block may lower confusion and pain after hip surgery in older adults
In a randomized, double-blind study of 84 older patients undergoing hip arthroplasty, ultrasound-guided PENG block with 0.25% bupivacaine re…
An ultrasound-guided PENG block lowers confusion and pain after hip surgery in older adults, helping them move earlier and use fewer painkil…
Apr 9, 2026
Liposomal bupivacaine, nerve blocks compared to lidocaine for skin graft donor site pain in burn patients
Emergency Medicine Phase IV
Liposomal bupivacaine, nerve blocks compared to lidocaine for skin graft donor site pain in burn patients What's the best way to ease pain after skin graft surgery for burn patients?
A two-phase study (RCT and prospective cohort) in 74 burn patients with <20% TBSA burns compared liposomal bupivacaine injection and preoper…
Burn patients with minor injuries face intense donor site pain after skin graft surgery, but doctors haven't yet reported which numbing meth…
CT.gov Apr 3, 2026