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Home › Medications › ketorolac

ketorolac

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of ketorolac

61 trials tracked of ketorolac: 35 in phase 3 or 4 and 9 with published results. The most-cited published study has 61 citations.

61Trials tracked
35Phase 3 & 4
0Recruiting
9With published results
Phase distribution
Phase 4 26 Phase 3 9 Phase 2 11 Phase 1 7 Other / NA 8
  1. Phase 4 Total Hip Arthroplasty (THA) Lumbar Plexus Verses Periarticular Completed · 61 cited
  2. Phase 4 MAST Trial: Multi-modal Analgesic Strategies in Trauma Completed · 51 cited
  3. Phase 4 Comparison of Ketorolac Nasal Spray to Sumatriptan Nasal Spray and Placebo for Acute Treatment of Migraine Completed · 36 cited
  4. Phase 4 Intravenous Lidocaine and Ketorolac for Pain Management Completed · 23 cited
  5. Phase 4 Impact of Local Anesthetic Wound Infiltration on Postoperative Pain Following Cesarean Delivery Completed · 12 cited
  6. Phase 3 Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery Completed · 5 cited
Show 44 more trials
  1. Phase 3 Increased Ketorolac Administration After Cesarean Section and Its Effect on Opioid Use: a Randomized Control Trial Completed · 4 cited
  2. Phase 3 A Pilot Clinical Trial of a New Neuromodulation Device for Acute Attacks of Migraine in Children and Adolescents Completed · 4 cited
  3. Phase 3 Meloxicam for Pain Management After Total Joint Arthroplasty (TJA) Completed
  4. Phase 4 Steroids After Laser Trabeculoplasty for Glaucoma Completed
  5. Phase 4 Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty Completed
  6. Phase 4 Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries Completed
  7. Phase 4 Valproate Versus Ketorolac Versus Metoclopramide Completed
  8. Phase 4 ON-Q Pump Infusion of Ketorolac and Ropivacaine at the Wound Site for Postoperative Pain Management Completed
  9. Phase 4 Oral Ketorolac for Pain Relief During IUD Insertion Completed
  10. Phase 4 A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty Completed
  11. Phase 4 A Comparison of NSAIDs for Acute, Non-radicular Low Back Pain. Completed
  12. Phase 4 Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery Completed
  13. Phase 4 Effect of Ketorolac on Post Adenotonsillectomy Pain Completed
  14. Phase 4 ICE-T Pain Regimen for Total Laparoscopic Hysterectomy Completed
  15. Phase 4 Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair Completed
  16. Phase 4 Study of Ketorolac Versus Opioid for Pain After Endoscopy Completed
  17. Phase 4 A Comparison of Prostaglandin E2 (PGE2) Inhibition of Acuvail(Ketorolac 0.45%), Xibrom (Bromfenac 0.09%)and Nevanac (Nepafenac)in Patients Undergoing Phacoemulsification Completed
  18. Phase 4 Intravenous Ketorolac for Postoperative Pain in Percutaneous Nephrolithotomy Completed
  19. Phase 4 Efficacy of Intravenous Ibuprofen Compared to Intravenous Ketorolac for Pain Control Following Arthroscopic Knee Surgery Completed
  20. Phase 4 Intravenous Ketorolac for Postoperative Pain in Laparoscopic Donor Nephrectomy Completed
  21. Phase 4 Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty Completed
  22. Phase 4 A Comparison of Naropin and Ketorolac for Postoperative Analgesia After Total Knee Arthroplasty Completed
  23. Phase 4 Metoclopramide Versus Ketorolac for Tension-type Headache Completed
  24. Phase 4 Periarticular Multimodal Drug Injections in Total Knee Arthroplasty Completed
  25. Phase 3 Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery Completed
  26. Phase 3 Oral Ketorolac for Arthroscopic Rotator Cuff Repair Completed
  27. Phase 3 Multimodal Pain Management After Robotic-Assisted Total Laparoscopic Hysterectomy Completed
  28. Phase 3 Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction Completed
  29. Phase 3 A Study of Ketorolac for the Treatment of Inflammation and Pain Associated With Cataract Surgery Completed
  30. Phase 2 Study Evaluating the Effects of Toradol and Lyrica for Pain Control After Donor Nephrectomy Completed
  31. Phase 2 Synergistic Pharmacologic Intervention for Prevention of ROP (SPIPROP Study) Completed
  32. Phase 2 Study of CA-008 (Vocacapsaicin) in Bunionectomy Patients Completed
  33. Phase 2 Prospective Randomized Controlled Trial for Pain Relief After Office Ureteral Stent Removal Completed
  34. Phase 2 Phase 2 Herniorrhaphy Study for Opioid Elimination Completed
  35. Phase 2 Study of the Safety, Tolerability and Analgesic Efficacy of Multiple Doses of Ketorolac Tromethamine (IN) for Postoperative Pain Completed
  36. Phase 2 Enhanced Recovery at Cesarean Birth to Improve Postoperative Outcomes and Reduce Postoperative Length of Stay Completed
  37. Phase 2 Open-Label CA-008 (Vocacapsaicin) in Bunionectomy Completed
  38. Phase 2 Nonopioid Analgesia After Rotator Cuff Repair Completed
  39. Phase 2 Toradol v. Celecoxib for Postoperative Pain Completed
  40. Phase 2 Efficacy and Safety of Intranasal Ketorolac for the Acute Treatment of Migraine Completed
  41. Phase 1 Tolerability, Safety and Pharmacokinetics of Four Formulations of Ketorolac Tromethamine in Healthy Volunteers Completed
  42. Phase 1 Inflammatory Markers in Trauma Patient Outcomes Completed
  43. Phase 1 Study to Assess the Absorption and Tolerability of Intranasal Ketorolac Tromethamine and to Assess the Effects of Oxymetazoline Hydrochloride and Fluticasone Propionate on the Absorption and Tolerability of Intranasal Ketorolac Tromethamine in Participants With Allergic Rhinitis Completed
  44. Phase 1 Open Label Study to Assess the Pharmacokinetics of Intranasal Ketorolac Tromethamine Following Fluticasone Propionate in Healthy Subjects Completed

Showing the 50 most-cited and recently-updated of 61 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Network meta-analysis compares 155 analgesic regimens for pain after knee and hip arthroplasty
Anesthesiology & Pain Medicine Meta-analysis
Network meta-analysis compares 155 analgesic regimens for pain after knee and hip arthroplasty Study Compares 155 Pain Relief Methods After Knee and Hip Replacement Surgery
A network meta-analysis of 211 RCTs involving 22,972 patients compared 155 analgesic regimens for postoperative pain after knee or hip arthr…
Patients recovering from knee or hip surgery can find which of 155 pain relief methods best controls pain and improves movement in the first…
Apr 9, 2026
Opioid-sparing PCA non-inferior to opioid PCA for pain after total knee arthroplasty
Anesthesiology & Pain Medicine RCT
Opioid-sparing PCA non-inferior to opioid PCA for pain after total knee arthroplasty Opioid-sparing pain control after knee replacement shows similar pain relief with less nausea
A randomized controlled trial of 98 patients undergoing total knee arthroplasty found an opioid-sparing PCA regimen (ketorolac and nefopam) …
A new pain method after knee replacement works just as well as standard care but cuts nausea from 35% down to 12%.
Apr 2, 2026
Ketorolac shows early analgesic advantage for post-endodontic pain at 6 hours in meta-analysis
Anesthesiology & Pain Medicine Meta-analysis
Ketorolac shows early analgesic advantage for post-endodontic pain at 6 hours in meta-analysis Which pain reliever works best after a root canal? Ketorolac may help most in the first 6 hours
A systematic review and meta-analysis of 7 studies in patients undergoing root canal therapy found ketorolac provided statistically signific…
Ketorolac offers the best pain relief in the first six hours after a root canal, reducing the need for extra rescue doses compared to other …
Apr 2, 2026