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Home › Medications › liraglutide

liraglutide

26 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of liraglutide

99 trials tracked of liraglutide: 68 in phase 3 or 4 and 35 with published results. The most-cited published study has 7545 citations.

99Trials tracked
68Phase 3 & 4
0Recruiting
35With published results
Phase distribution
Phase 4 17 Phase 3 51 Phase 2 21 Phase 1 6 Other / NA 4
  1. Phase 3 Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results Completed · 7,545 cited
  2. Phase 3 Research Study to Investigate How Well Semaglutide Works Compared to Liraglutide in People Living With Overweight or Obesity Completed · 911 cited
  3. Phase 3 Effect of Liraglutide for Weight Management in Pubertal Adolescent Subjects With Obesity Completed · 699 cited
  4. Phase 3 Efficacy and Safety of Oral Semaglutide Versus Liraglutide and Versus Placebo in Subjects With Type 2 Diabetes Mellitus Completed · 591 cited
  5. Phase 3 Research Study Comparing a New Medicine Semaglutide to Liraglutide in People With Type 2 Diabetes Completed · 420 cited
  6. Phase 3 Dual Action of Liraglutide and Insulin Degludec in Type 2 Diabetes: A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide, Insulin Degludec and Liraglutide in Subjects With Type 2 Diabetes Completed · 363 cited
Show 44 more trials
  1. Phase 3 Efficacy and Safety of Liraglutide in Combination With Metformin Compared to Metformin Alone, in Children and Adolescents With Type 2 Diabetes Completed · 355 cited
  2. Phase 3 The Efficacy and Safety of Liraglutide as Adjunct Therapy to Insulin in the Treatment of Type 1 Diabetes Completed · 340 cited
  3. Phase 4 Liraglutide in Obesity and Diabetes: Identification of CNS Targets Using fMRI Completed · 278 cited
  4. Phase 3 The Efficacy and Safety of Liraglutide Adjunct to Insulin Treatment in Type 1 Diabetes Completed · 259 cited
  5. Phase 4 Effect of Liraglutide on Epicardial Fat in Subjects With Type 2 Diabetes Completed · 245 cited
  6. Phase 3 Dose-response, Safety and Efficacy of Oral Semaglutide Versus Placebo and Versus Liraglutide, All as Monotherapy in Japanese Subjects With Type 2 Diabetes Completed · 227 cited
  7. Phase 3 Individualized Obesity Pharmacotherapy Completed · 208 cited
  8. Phase 4 Impact of Liraglutide 3.0 on Body Fat Distribution Completed · 196 cited
  9. Phase 3 Effect and Safety of Liraglutide 3.0 mg as an Adjunct to Intensive Behaviour Therapy for Obesity in a Non-specialist Setting Completed · 194 cited
  10. Phase 3 The Efficacy of Insulin Degludec/Liraglutide in Controlling Glycaemia in Adults With Type 2 Diabetes Inadequately Controlled on GLP-1 Receptor Agonist and OAD Therapy Completed · 135 cited
  11. Phase 4 The Effect of Liraglutide Treatment on Postprandial Chylomicron and VLDL Kinetics, Liver Fat and de Novo Lipogenesis Completed · 131 cited
  12. Phase 3 Liraglutide and a Calorie Restricted Diet Augments Weight Loss and Decreases Risk of Type 2 Diabetes and CVD. Completed · 122 cited
  13. Phase 3 Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabetes, With a FRC Extension Period Completed · 83 cited
  14. Phase 4 Study of Management of Pasireotide-induced Hyperglycemia in Adult Patients With Cushing's Disease or Acromegaly Completed · 80 cited
  15. Phase 4 Adding Liraglutide to High Dose Insulin: Breaking the Cycle Completed · 76 cited
  16. Phase 3 Effect of Liraglutide for Weight Management in Paediatric Subjects With Prader-Willi Syndrome Completed · 72 cited
  17. Phase 3 Dapagliflozin As Additional Treatment To Liraglutide And Insulin In Patients With Type 1 Diabetes Completed · 71 cited
  18. Phase 4 The Effect of Simple Basal Insulin Titration, Metformin Plus Liraglutide for Type 2 Diabetes With Very Elevated HbA1c - The SIMPLE Study Completed · 56 cited
  19. Phase 4 Liraglutide and Peripheral Artery Disease Completed · 56 cited
  20. Phase 3 LIRA-ADD2SGLT2i - Liraglutide Versus Placebo as add-on to SGLT2 Inhibitors. Completed · 53 cited
  21. Phase 3 RISE Adult Medication Study Completed · 45 cited
  22. Phase 3 Study to Assess the Efficacy of Liraglutide in Patients With Type 2 Diabetes Mellitus Completed · 44 cited
  23. Phase 4 52 Week Trial of Liraglutide in Type 1 Diabetes Completed · 38 cited
  24. Phase 4 Efficacy and Safety of Switching From Sitagliptin to Liraglutide in Subjects With Type 2 Diabetes Not Achieving Adequate Glycaemic Control on Sitagliptin and Metformin Completed · 35 cited
  25. Phase 3 The Effect of Insulin Degludec in Combination With Liraglutide and Metformin in Subjects With Type 2 Diabetes Qualifying for Treatment Intensification Completed · 33 cited
  26. Phase 3 A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide, Insulin Degludec and Liraglutide in Japanese Subjects With Type 2 Diabetes Mellitus. Completed · 25 cited
  27. Phase 3 A Trial Comparing Insulin Degludec/Liraglutide, Insulin Degludec, and Liraglutide in Chinese Subjects With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs (OADs) Completed · 17 cited
  28. Phase 4 Efficacy in Controlling Glycaemia With Victoza® (Liraglutide) as add-on to Metformin vs. OADs as add-on to Metformin After up to 104 Weeks of Treatment in Subjects With Type 2 Diabetes Completed · 12 cited
  29. Phase 3 The Effect of Glucagon-like-peptide 1 (GLP-1) Receptor Agonism on Diabetic Kidney Disease Completed · 12 cited
  30. Phase 4 Cardiovascular Effects of GLP-1 Receptor Activation Completed
  31. Phase 4 A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America Completed
  32. Phase 4 Efficacy and Safety of Liraglutide Versus Lixisenatide as add-on to Metformin in Subjects With Type 2 Diabetes Completed
  33. Phase 4 The Efficacy and Safety of Liraglutide Compared to Sitagliptin, Both in Combination With Metformin in Chinese Subjects With Type 2 Diabetes Completed
  34. Phase 4 Efficacy Assessment of Insulin Glargine Versus LiraglutidE After Oral Agents Failure Completed
  35. Phase 4 Efficacy and Safety of Liraglutide Versus Sulphonylurea Both in Combination With Metformin During Ramadan in Subjects With Type 2 Diabetes Completed
  36. Phase 3 Antidiabetic Effects of Adding a DPP-4 Inhibitor to Pre-Existing Treatment With an Incretin Mimetic in Patients With T2D Completed
  37. Phase 3 A Trial Comparing the Efficacy and Safety of Liraglutide 1.8 mg/Day to Liraglutide 0.9 mg/Day in Japanese Subjects With Type 2 Diabetes Mellitus. Completed
  38. Phase 3 Liraglutide In Overweight Patients With Type 1 Diabetes Completed
  39. Phase 3 Liraglutide in Adolescents With Type 1 Diabetes Completed
  40. Phase 3 Efficacy and Safety of Liraglutide in Combination With Insulin Therapy Compared to Insulin Alone in Japanese Subjects With Type 2 Diabetes Completed
  41. Phase 3 Effect of Liraglutide on Body Weight in Overweight or Obese Subjects With Type 2 Diabetes: SCALE™ - Diabetes Completed
  42. Phase 3 Comparison of the Efficacy and Safety of Two Intensification Strategies in Subjects With Type 2 Diabetes Inadequately Controlled on Basal Insulin and Metformin Completed
  43. Phase 3 Efficacy and Safety of Liraglutide Versus Placebo as add-on to Existing Diabetes Medication in Subjects With Type 2 Diabetes and Moderate Renal Impairment Completed
  44. Phase 3 Comparison of Two Treatment Regimens (Sitagliptin Versus Liraglutide) on Participants Who Failed to Achieve Good Glucose Control on Metformin Alone (MK-0431-403) Completed

Showing the 50 most-cited and recently-updated of 99 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

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Patient Mode — summaries use plain language, avoiding clinical jargon.
Short-term liraglutide modulates proteins in obesity, showing weight-independent effects and myostatin suppression
Nutrition & Obesity Medicine RCT
Short-term liraglutide modulates proteins in obesity, showing weight-independent effects and myostatin suppression Could a weight-loss drug work by changing your body's proteins?
A 5-week randomized trial in 20 adults with obesity found liraglutide 3 mg daily modulated 124 proteins, with 85% of effects persisting afte…
A weight-loss drug changed 124 blood proteins in a small study, with 85% of shifts not tied to weight loss, hinting at deeper body-wide effe…
Apr 4, 2026
GLP-1 Receptor Agonist Use in Wolfram Syndrome Shows No Glycemic or BMI Benefit, Common GI Effects
Diabetes & Endocrinology Cohort
GLP-1 Receptor Agonist Use in Wolfram Syndrome Shows No Glycemic or BMI Benefit, Common GI Effects Can diabetes drugs help Wolfram syndrome? A new study looks at real-world use
A retrospective cohort study of 84 participants with genetically confirmed Wolfram syndrome and insulin-dependent diabetes found 35% had rec…
Doctors prescribed diabetes drugs to 35% of rare Wolfram syndrome patients, but records show no improvement in blood sugar, weight, or slowi…
medRxiv Apr 4, 2026