Computational model review predicts dual optima for combination therapy in ageing
New math model shows combining drugs could slow aging better than weight loss alone
This review of a computational model explores combination therapy with semaglutide, SGLT2 inhibitors, metformin, and rapamycin for ageing.
A new computer model reveals that fixing blood sugar and slowing aging are separate tasks, meaning some drugs might help you live longer eve…
Meta-analysis finds preadmission metformin use associated with reduced mortality in diabetic sepsis patients
Metformin Linked to Lower Sepsis Death Risk
This systematic review and meta-analysis of 14 studies (12,687 patients) examined preadmission metformin use in diabetic sepsis patients.
Diabetic patients taking metformin before sepsis face nearly 40% lower death risk, suggesting this common pill may quietly boost survival du…
Narrative review explores metformin and trimetazidine in cardiovascular conditions
The Hidden Cell Death Process Quietly Driving Heart Disease
This narrative review examines the roles of metformin and trimetazidine in cardiovascular diseases, atherosclerosis, vascular calcification,…
A specific type of cell death driven by iron and fat damage plays a key role in multiple heart conditions, including heart failure and ather…
Review summarizes fenofibrate, metformin, and MSC modulation in Primary Sjögren disease management
The Dry Mouth Disease Has an Immune Fix Researchers Didn't Expect
This review examines the potential of fenofibrate, metformin, and mesenchymal stem cells in Primary Sjögren disease management.
Three existing drugs may restore the immune balance broken in Sjögren's disease, a chronic condition that destroys saliva and tear glands.
Bayesian network meta-analysis evaluates antidiabetic medications and dementia risk in 4,382,897 patients
Could diabetes drugs lower dementia risk, or raise it for some patients?
This Bayesian network meta-analysis synthesized data from 28 articles involving 4,382,897 patients to assess antidiabetic drugs and dementia…
Insulin and metformin cut dementia risk, but DPP4 inhibitors may double Alzheimer's risk compared to SGLT2 drugs in diabetes patients.
Mini-review links insulin to worse COVID-19 outcomes in type 2 diabetes patients
Diabetes Meds Do Not Stop COVID-19
A mini-review of observational studies in patients with type 2 diabetes mellitus found that insulin was linked to worse COVID-19 outcomes, w…
Recent research proves that common diabetes pills do not protect you from getting sick or dying from a virus infection.
Orforglipron shows superior HbA1c reduction versus oral semaglutide in adults with type 2 diabetes on metformin
A New Diabetes Pill Takes On Ozempic's Oral Cousin
A phase 3 RCT of 1698 adults with type 2 diabetes inadequately controlled on metformin found that once-daily oral orforglipron (12 mg or 36 …
A new once-daily diabetes pill called orforglipron lowered blood sugar better than oral semaglutide in a major head-to-head trial, but at th…
Semaglutide dose linked to lower mortality and cardiovascular risk in patients with baseline CVD
Why Ozempic's Heart Benefits May Have Nothing to Do With Weight Loss
An observational study of 47,199 patients with baseline cardiovascular disease in a U.S.
A massive real-world study of over 47,000 heart patients suggests that semaglutide may protect the heart through direct biological effects —…
Meta-analysis finds liraglutide improves menstrual frequency and BMI in overweight women with PCOS
A Common Weight Loss Drug May Ease a Hidden Cause of Infertility
A systematic review and meta-analysis of 330 overweight or obese women with PCOS found liraglutide significantly increased menstrual frequen…
A common weight loss drug helps overweight women with PCOS restore regular periods and improve metabolic health.
Systematic review links neutrophil extracellular trap dysregulation to pregnancy complications
Web of White Blood Cells Linked to Pregnancy Risks
A systematic review of emerging evidence indicates that dysregulation of neutrophil extracellular trap (NET) formation and clearance is stro…
A sticky web of white blood cells meant to fight germs can instead trigger serious pregnancy risks like preeclampsia and preterm birth when …
FDA Approves Dapagliflozin and Metformin Hydrochloride Extended-Release Tablets for Type 2 Diabetes and Related Risks
FDA approves a new once-daily pill for type 2 diabetes that may also help protect the heart and kidneys
The FDA has approved dapagliflozin and metformin hydrochloride extended-release tablets as an adjunct to diet and exercise to improve glycem…
A new once-daily pill for type 2 diabetes may protect the heart and kidneys from serious problems like heart attacks and worsening kidney di…
Oral quadruple therapy reduces HbA more than metformin uptitration in type 2 diabetes on triple therapy
When three diabetes pills aren't enough, does adding a fourth help more than increasing metformin?
A 24-week, multicenter RCT in 193 adults with type 2 diabetes (HbA 7.0-9.0%) on triple oral therapy compared adding a fourth oral agent vers…
When three diabetes pills fail to control blood sugar, adding a fourth medication lowered HbA1c better than simply increasing the metformin …