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Home › Medications › metformin

metformin

49 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of metformin

328 trials tracked of metformin: 202 in phase 3 or 4 and 57 with published results. The most-cited published study has 360 citations.

328Trials tracked
202Phase 3 & 4
0Recruiting
57With published results
Phase distribution
Phase 4 68 Phase 3 134 Phase 2 73 Phase 1 33 Other / NA 20
  1. Phase 4 VERIFY:A Study to Compare Combination Regimen With Vildagliptin & Metformin Versus Metformin in Treatment-naïve Patients With Type 2 Diabetes Mellitus Completed · 360 cited
  2. Phase 3 Efficacy and Safety of Liraglutide in Combination With Metformin Compared to Metformin Alone, in Children and Adolescents With Type 2 Diabetes Completed · 355 cited
  3. Phase 3 REducing With MetfOrmin Vascular Adverse Lesions in Type 1 Diabetes (REMOVAL) Completed · 354 cited
  4. Phase 3 GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Basal Insulin Completed · 288 cited
  5. Phase 3 Efficacy and Safety of Insulin Glargine/ Lixisenatide Fixed Ratio Combination Compared to Insulin Glargine Alone and Lixisenatide Alone on Top of Metformin in Patients With T2DM Completed · 271 cited
  6. Phase 3 A Study of Dulaglutide (LY2189265) in Participants With Type 2 Diabetes Mellitus Completed · 267 cited
Show 44 more trials
  1. Phase 3 GLP-1 Receptor Agonist Lixisenatide Versus Exenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin Completed · 254 cited
  2. Phase 3 24-week Treatment With Lixisenatide in Type 2 Diabetes Insufficiently Controlled With Metformin and Insulin Glargine Completed · 252 cited
  3. Phase 3 COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) Completed · 249 cited
  4. Phase 4 Effect of Liraglutide on Epicardial Fat in Subjects With Type 2 Diabetes Completed · 245 cited
  5. Phase 3 A Phase III Randomized Trial of Metformin vs Placebo in Early Stage Breast Cancer Completed · 238 cited
  6. Phase 3 A Study To Evaluate The Efficacy And Safety Of Ertugliflozin In Participants With Type 2 Diabetes Mellitus And Inadequate Glycemic Control On Metformin Monotherapy (MK-8835-007). Completed · 191 cited
  7. Phase 3 RISE Pediatric Medication Study Completed · 176 cited
  8. Phase 3 GLP-1 Receptor Agonist Lixisenatide (Morning or Evening) in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin Completed · 172 cited
  9. Phase 3 Safety and Efficacy of Ertugliflozin in the Treatment of Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin and Sitagliptin (MK-8835-006; VERTIS SITA2) Completed · 161 cited
  10. Phase 3 A Study of the Efficacy and Safety of Ertugliflozin Monotherapy in the Treatment of Participants With Type 2 Diabetes Mellitus and Inadequate Glycemic Control Despite Diet and Exercise (MK-8835-003, VERTIS MONO) Completed · 146 cited
  11. Phase 3 GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin Completed · 143 cited
  12. Phase 3 EMERALD: Effects of Metformin on Cardiovascular Function in Adolescents With Type 1 Diabetes Completed · 143 cited
  13. Phase 3 GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Pioglitazone Completed · 138 cited
  14. Phase 4 FLuctuATion Reduction With inSULin and Glp-1 Added togetheR (FLAT-SUGAR) Completed · 134 cited
  15. Phase 3 GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Sulfonylurea Completed · 128 cited
  16. Phase 3 Treatment of Overweight Induced by Antipsychotic Medication in Young People With Autism Spectrum Disorders (ASD) Completed · 120 cited
  17. Phase 3 Diabetes Study of Linagliptin and Empagliflozin in Children and Adolescents (DINAMO)TM Completed · 105 cited
  18. Phase 3 RCT Metformin for Reduction of Gestational Diabetes Mellitus Effects Completed · 90 cited
  19. Phase 3 Prevention of Metabolic Complications of Glucocorticoid Excess Completed · 88 cited
  20. Phase 4 Effect of Dapagliflozin on 24-hour Blood Glucose in T2DM Patients Inadequately Controlled With Either Metformin Or Insulin Completed · 82 cited
  21. Phase 4 Study of Management of Pasireotide-induced Hyperglycemia in Adult Patients With Cushing's Disease or Acromegaly Completed · 80 cited
  22. Phase 3 Efficacy and Safety of Lixisenatide in Patients With Type 2 Diabetes Mellitus Insufficiently Controlled by Metformin Completed · 70 cited
  23. Phase 3 A Study of LY900014 Compared to Insulin Lispro in Participants With Type 2 Diabetes Completed · 69 cited
  24. Phase 4 Effects of Metformin on Hepatic FFA Metabolism Completed · 64 cited
  25. Phase 4 The Effect of Simple Basal Insulin Titration, Metformin Plus Liraglutide for Type 2 Diabetes With Very Elevated HbA1c - The SIMPLE Study Completed · 56 cited
  26. Phase 3 A Study to Assess the Addition of Sitagliptin to Metformin Compared With the Addition of Dapagliflozin to Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) and Mild Renal Impairment Who Have Inadequate Glycemic Control on Metformin With or Without a Sulfonylurea (MK-0431-838) Completed · 56 cited
  27. Phase 4 Remission Evaluation of Metabolic Interventions in Type 2 Diabetes (REMIT Pilot Trial) Completed · 53 cited
  28. Phase 3 Effect of Vildagliptin vs. Glibenclamide on Circulating Endothelial Progenitor Cell Number Type 2 Diabetes Completed · 53 cited
  29. Phase 3 A Study to Evaluate the Efficacy and Safety of Ertugliflozin in Asian Participants With Type 2 Diabetes and Inadequate Glycemic Control on Metformin Monotherapy (MK-8835-012) Completed · 53 cited
  30. Phase 3 Ertugliflozin vs. Glimepiride in Type 2 Diabetes Mellitus (T2DM) Participants on Metformin (MK-8835-002) Completed · 50 cited
  31. Phase 4 The Health Influences of Puberty (HIP) Study Completed · 47 cited
  32. Phase 3 RISE Adult Medication Study Completed · 45 cited
  33. Phase 3 Metformin to Reduce Heart Failure After Myocardial Infarction Completed · 45 cited
  34. Phase 4 Remission Evaluation of a Metabolic Intervention in Type 2 Diabetes With Forxiga Completed · 33 cited
  35. Phase 3 Study to Assess Safety & Efficacy of Sitagliptin as Initial Oral Therapy for Treatment of Type 2 Diabetes Mellitus in Pediatric Participants. (MK-0431-083) Completed · 32 cited
  36. Phase 3 Exercise Dose and Metformin for Vascular Health in Metabolic Syndrome Completed · 32 cited
  37. Phase 3 A Pooled Analysis of the Safety and Efficacy of MK-0431A and MK-0431A XR in Pediatric Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Therapy (Alone or in Combination With Insulin) (MK-0431A-170/MK-0431A-289) Completed · 31 cited
  38. Phase 3 Research Study Comparing a New Medicine "Fast-acting Insulin Aspart" to Another Already Available Medicine "NovoRapid"/"NovoLog" in People With Type 2 Diabetes Completed · 26 cited
  39. Phase 4 Reducing Weight Gain and Improving Metabolic Function in Children Being Treated With Antipsychotics Completed · 22 cited
  40. Phase 3 A Study of Dulaglutide (LY2189265) in Participants With Type II Diabetes Completed · 20 cited
  41. Phase 3 Randomized Sitagliptin Withdrawal Study (MK-0431-845) Completed · 19 cited
  42. Phase 3 Comparison of Lixisenatide Injected Prior to the Main Meal of the Day Versus Prior to Breakfast in Type 2 Diabetic Patients on Metformin Completed · 19 cited
  43. Phase 3 A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on Metformin Completed · 18 cited
  44. Phase 4 Metformin and Its Impact on the Substances Associated With NO Production in Prediabetes Patients. Completed · 17 cited

Showing the 50 most-cited and recently-updated of 328 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Phase 2 trial tests metformin with neoadjuvant radiochemotherapy for locally advanced rectal cancer
Gastroenterology Phase II
Phase 2 trial tests metformin with neoadjuvant radiochemotherapy for locally advanced rectal cancer Could a common diabetes drug help people with rectal cancer respond better to treatment?
A Phase 2 trial (n=60) evaluated adding metformin to neoadjuvant radiochemotherapy (capecitabine + 50 Gy radiation) for locally advanced rec…
Adding a common diabetes pill to pre-surgery treatment for rectal cancer may help clear out cancer cells before the operation begins.
CT.gov Mar 30, 2026