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Home › Medications › metformin

metformin

40 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of metformin

328 trials tracked of metformin: 202 in phase 3 or 4 and 57 with published results. The most-cited published study has 355 citations.

328Trials tracked
202Phase 3 & 4
0Recruiting
57With published results
Phase distribution
Phase 4 68 Phase 3 134 Phase 2 73 Phase 1 33 Other / NA 20
  1. Phase 4 VERIFY:A Study to Compare Combination Regimen With Vildagliptin & Metformin Versus Metformin in Treatment-naïve Patients With Type 2 Diabetes Mellitus Completed · 355 cited
  2. Phase 3 REducing With MetfOrmin Vascular Adverse Lesions in Type 1 Diabetes (REMOVAL) Completed · 351 cited
  3. Phase 3 Efficacy and Safety of Liraglutide in Combination With Metformin Compared to Metformin Alone, in Children and Adolescents With Type 2 Diabetes Completed · 350 cited
  4. Phase 3 GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Basal Insulin Completed · 285 cited
  5. Phase 3 Efficacy and Safety of Insulin Glargine/ Lixisenatide Fixed Ratio Combination Compared to Insulin Glargine Alone and Lixisenatide Alone on Top of Metformin in Patients With T2DM Completed · 270 cited
  6. Phase 3 A Study of Dulaglutide (LY2189265) in Participants With Type 2 Diabetes Mellitus Completed · 263 cited
Show 44 more trials
  1. Phase 3 GLP-1 Receptor Agonist Lixisenatide Versus Exenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin Completed · 251 cited
  2. Phase 3 24-week Treatment With Lixisenatide in Type 2 Diabetes Insufficiently Controlled With Metformin and Insulin Glargine Completed · 251 cited
  3. Phase 3 COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) Completed · 247 cited
  4. Phase 4 Effect of Liraglutide on Epicardial Fat in Subjects With Type 2 Diabetes Completed · 246 cited
  5. Phase 3 A Phase III Randomized Trial of Metformin vs Placebo in Early Stage Breast Cancer Completed · 229 cited
  6. Phase 3 A Study To Evaluate The Efficacy And Safety Of Ertugliflozin In Participants With Type 2 Diabetes Mellitus And Inadequate Glycemic Control On Metformin Monotherapy (MK-8835-007). Completed · 190 cited
  7. Phase 3 RISE Pediatric Medication Study Completed · 176 cited
  8. Phase 3 GLP-1 Receptor Agonist Lixisenatide (Morning or Evening) in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin Completed · 171 cited
  9. Phase 3 Safety and Efficacy of Ertugliflozin in the Treatment of Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin and Sitagliptin (MK-8835-006; VERTIS SITA2) Completed · 161 cited
  10. Phase 3 A Study of the Efficacy and Safety of Ertugliflozin Monotherapy in the Treatment of Participants With Type 2 Diabetes Mellitus and Inadequate Glycemic Control Despite Diet and Exercise (MK-8835-003, VERTIS MONO) Completed · 146 cited
  11. Phase 3 GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin Completed · 143 cited
  12. Phase 3 EMERALD: Effects of Metformin on Cardiovascular Function in Adolescents With Type 1 Diabetes Completed · 143 cited
  13. Phase 3 GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Pioglitazone Completed · 137 cited
  14. Phase 4 FLuctuATion Reduction With inSULin and Glp-1 Added togetheR (FLAT-SUGAR) Completed · 134 cited
  15. Phase 3 GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Sulfonylurea Completed · 126 cited
  16. Phase 3 Treatment of Overweight Induced by Antipsychotic Medication in Young People With Autism Spectrum Disorders (ASD) Completed · 118 cited
  17. Phase 3 Diabetes Study of Linagliptin and Empagliflozin in Children and Adolescents (DINAMO)TM Completed · 104 cited
  18. Phase 3 Prevention of Metabolic Complications of Glucocorticoid Excess Completed · 86 cited
  19. Phase 3 RCT Metformin for Reduction of Gestational Diabetes Mellitus Effects Completed · 84 cited
  20. Phase 4 Effect of Dapagliflozin on 24-hour Blood Glucose in T2DM Patients Inadequately Controlled With Either Metformin Or Insulin Completed · 82 cited
  21. Phase 4 Study of Management of Pasireotide-induced Hyperglycemia in Adult Patients With Cushing's Disease or Acromegaly Completed · 80 cited
  22. Phase 3 A Study of LY900014 Compared to Insulin Lispro in Participants With Type 2 Diabetes Completed · 69 cited
  23. Phase 3 Efficacy and Safety of Lixisenatide in Patients With Type 2 Diabetes Mellitus Insufficiently Controlled by Metformin Completed · 69 cited
  24. Phase 4 Effects of Metformin on Hepatic FFA Metabolism Completed · 64 cited
  25. Phase 3 A Study to Assess the Addition of Sitagliptin to Metformin Compared With the Addition of Dapagliflozin to Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) and Mild Renal Impairment Who Have Inadequate Glycemic Control on Metformin With or Without a Sulfonylurea (MK-0431-838) Completed · 56 cited
  26. Phase 4 The Effect of Simple Basal Insulin Titration, Metformin Plus Liraglutide for Type 2 Diabetes With Very Elevated HbA1c - The SIMPLE Study Completed · 55 cited
  27. Phase 3 Effect of Vildagliptin vs. Glibenclamide on Circulating Endothelial Progenitor Cell Number Type 2 Diabetes Completed · 53 cited
  28. Phase 3 A Study to Evaluate the Efficacy and Safety of Ertugliflozin in Asian Participants With Type 2 Diabetes and Inadequate Glycemic Control on Metformin Monotherapy (MK-8835-012) Completed · 53 cited
  29. Phase 4 Remission Evaluation of Metabolic Interventions in Type 2 Diabetes (REMIT Pilot Trial) Completed · 51 cited
  30. Phase 3 Ertugliflozin vs. Glimepiride in Type 2 Diabetes Mellitus (T2DM) Participants on Metformin (MK-8835-002) Completed · 50 cited
  31. Phase 4 The Health Influences of Puberty (HIP) Study Completed · 45 cited
  32. Phase 3 RISE Adult Medication Study Completed · 45 cited
  33. Phase 3 Metformin to Reduce Heart Failure After Myocardial Infarction Completed · 42 cited
  34. Phase 4 Remission Evaluation of a Metabolic Intervention in Type 2 Diabetes With Forxiga Completed · 32 cited
  35. Phase 3 Study to Assess Safety & Efficacy of Sitagliptin as Initial Oral Therapy for Treatment of Type 2 Diabetes Mellitus in Pediatric Participants. (MK-0431-083) Completed · 32 cited
  36. Phase 3 Exercise Dose and Metformin for Vascular Health in Metabolic Syndrome Completed · 32 cited
  37. Phase 3 A Pooled Analysis of the Safety and Efficacy of MK-0431A and MK-0431A XR in Pediatric Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Therapy (Alone or in Combination With Insulin) (MK-0431A-170/MK-0431A-289) Completed · 31 cited
  38. Phase 3 Research Study Comparing a New Medicine "Fast-acting Insulin Aspart" to Another Already Available Medicine "NovoRapid"/"NovoLog" in People With Type 2 Diabetes Completed · 26 cited
  39. Phase 4 Reducing Weight Gain and Improving Metabolic Function in Children Being Treated With Antipsychotics Completed · 22 cited
  40. Phase 3 A Study of Dulaglutide (LY2189265) in Participants With Type II Diabetes Completed · 20 cited
  41. Phase 3 Randomized Sitagliptin Withdrawal Study (MK-0431-845) Completed · 19 cited
  42. Phase 3 Comparison of Lixisenatide Injected Prior to the Main Meal of the Day Versus Prior to Breakfast in Type 2 Diabetic Patients on Metformin Completed · 19 cited
  43. Phase 3 A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on Metformin Completed · 18 cited
  44. Phase 4 Metformin and Its Impact on the Substances Associated With NO Production in Prediabetes Patients. Completed · 17 cited

Showing the 50 most-cited and recently-updated of 328 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Phase 4 trial compares pioglitazone versus dapagliflozin add-on in type 2 diabetes
Diabetes & Endocrinology Phase IV
Phase 4 trial compares pioglitazone versus dapagliflozin add-on in type 2 diabetes Trial compares two diabetes drug combinations but results are not yet available
A phase 4 randomized controlled trial in South Korea enrolled 133 participants with type 2 diabetes inadequately controlled by DPP-4 inhibit…
A completed trial in South Korea compared two three-drug combinations for type 2 diabetes, but results on blood sugar control are not yet av…
CT.gov Apr 3, 2026
Offline peer support improves BMI and glucose in type 2 diabetes; hybrid support reduces HbA1c
Diabetes & Endocrinology Meta-analysis
Offline peer support improves BMI and glucose in type 2 diabetes; hybrid support reduces HbA1c Offline peer support linked to better weight and blood sugar in type 2 diabetes
A systematic review and meta-analysis of adults with type 2 diabetes found offline peer support significantly improved body-mass index and f…
In-person peer support for type 2 diabetes improved weight and blood sugar, while mixing online and offline help lowered long-term blood sug…
Apr 2, 2026
Metformin with standard therapy shows no significant survival benefit in gynecologic cancers
Drug Pipeline Meta-analysis
Metformin with standard therapy shows no significant survival benefit in gynecologic cancers Does adding metformin to cancer treatment help women with gynecologic cancers?
A meta-analysis of 5 RCTs involving 705 patients with gynecologic malignancies found metformin combined with standard therapy did not signif…
Adding the diabetes drug metformin to standard cancer treatment did not help women with gynecologic cancers live longer or delay disease pro…
Frontiers Mar 31, 2026
Phase 2 trial tests metformin with neoadjuvant radiochemotherapy for locally advanced rectal cancer
Gastroenterology Phase II
Phase 2 trial tests metformin with neoadjuvant radiochemotherapy for locally advanced rectal cancer Could a common diabetes drug help people with rectal cancer respond better to treatment?
A Phase 2 trial (n=60) evaluated adding metformin to neoadjuvant radiochemotherapy (capecitabine + 50 Gy radiation) for locally advanced rec…
Adding a common diabetes pill to pre-surgery treatment for rectal cancer may help clear out cancer cells before the operation begins.
CT.gov Mar 30, 2026