Metformin shows limited impact on gonadotropin levels in PCOS women
Metformin changes one hormone ratio but leaves others unchanged in PCOS
A meta-analysis of 51 RCTs finds metformin does not alter FSH or LH but significantly increases the LH/FSH ratio in women with PCOS.
Metformin treatment significantly increased the LH to FSH ratio in women with PCOS, while leaving FSH and LH levels alone.
Paternal metformin use during spermatogenesis shows no increased risk for major congenital malformations in over 11 000 children across five countries
New analysis shows fathers taking metformin did not raise birth defect risks for their children
A large meta-analysis involving more than 11 000 live-born children found no association between fathers taking metformin and birth defects.…
A large study of over 11,000 children found no higher risk of birth defects when dads took metformin before conception. This good news appli…
Triple oral therapy with metformin, SGLT-2, and DPP-4 inhibitors lowers HbA1c better than dual regimens in adults with type 2 diabetes
Triple oral diabetes drugs lower blood sugar better than two-drug regimens
A systematic review and meta-analysis of 2,606 adults with type 2 diabetes found that triple oral therapy combining metformin, an SGLT-2 inh…
A large analysis shows that taking three specific oral diabetes medicines together lowers blood sugar more effectively than taking just two …
Systematic review and meta-analysis of metformin for pediatric overweight and obesity shows modest BMI reduction
Metformin shows promise for weight management in children with overweight or obesity
This systematic review and meta-analysis evaluated metformin versus placebo in children with overweight or obesity across 19 original studie…
A meta-analysis of 19 studies suggests metformin may help lower BMI and weight in children with overweight or obesity compared to placebo.
Narrative review suggests precision interventions for preeclampsia phenotypes
At-a-Glance
This narrative review examines prevention strategies for preeclampsia in pregnant women. The authors note that standard low-dose aspirin eff…
Preeclampsia prevention is moving beyond aspirin for everyone, with new research showing that matching treatments to a woman's specific risk…
Guideline on severe pediatric obesity with MC4R variant and puberty management
Two siblings with severe obesity and early puberty found to have genetic changes affecting their growth and health over fourteen years
This guideline, based on a case report of two Chinese siblings with a heterozygous MC4R variant, synthesizes long-term management of monogen…
Two Chinese brothers with severe obesity and early puberty received special treatments for fourteen years. Their puberty slowed down, blood …
Nurse-led care coordination fails to improve medication adherence in high-need patients
Nurse-led care coordination did not improve medication adherence for most common chronic conditions
This pragmatic randomized controlled trial tested nurse-led care coordination versus usual care in high-need, high-cost commercially insured…
A large trial found that nurse-led care coordination did not improve how often people took their diabetes, heart, or thyroid medications com…
Review of NHANES data links metformin use to lower mortality and inflammatory markers in type 2 diabetes
Metformin use linked to lower death risk and better inflammation markers in U.S. adults with diabetes
This review of NHANES 2013-2018 data (2,116 adults) found that metformin use was associated with lower all-cause and cardiovascular mortalit…
New analysis of U.S. adults with diabetes suggests metformin use connects to lower death risk and improved inflammation markers, though more…
Metformin, fluvoxamine, or ivermectin for non-hospitalized COVID-19 adults in a Phase 3 trial
Metformin Cuts Long Covid Risk by 40%
This randomized controlled trial in 1323 non-hospitalized adults with SARS-CoV-2 infection evaluated metformin, fluvoxamine, or ivermectin v…
A common diabetes pill taken early in Covid infection cuts the odds of developing long-term symptoms by 40%, offering new hope for millions.
Semaglutide linked to lower neuropsychiatric event risk vs other diabetes drugs in observational study
Semaglutide linked to lower neuropsychiatric risk than other diabetes drugs
This observational cohort study analyzed 63,215 patients with baseline neuropsychiatric conditions across a large US federated data platform…
A large observational study suggests semaglutide may be associated with a lower risk of neuropsychiatric conditions compared to other common…
Metformin use in Type 2 Diabetes shows inconsistent clinical effects in review
Metformin Does More Than Lower Blood Sugar For Your Health
This review examines metformin in over 150 million individuals worldwide receiving treatment annually for Type 2 Diabetes.
Metformin might be doing much more than just controlling blood sugar for people with diabetes.
Review of observational data links semaglutide and tirzepatide to survival in breast cancer
Semaglutide linked to lower death rates in breast cancer patients compared to other diabetes drugs
This review synthesized observational, propensity-matched analyses of patients with pre-existing breast cancer.
In routine care, semaglutide users with breast cancer had significantly lower death rates and less metastatic disease than those on other co…