Orforglipron shows superior HbA1c reduction versus oral semaglutide in adults with type 2 diabetes on metformin
A New Diabetes Pill Takes On Ozempic's Oral Cousin
A phase 3 RCT of 1698 adults with type 2 diabetes inadequately controlled on metformin found that once-daily oral orforglipron (12 mg or 36 …
A new once-daily diabetes pill called orforglipron lowered blood sugar better than oral semaglutide in a major head-to-head trial, but at th…
Semaglutide dose linked to lower mortality and cardiovascular risk in patients with baseline CVD
Why Ozempic's Heart Benefits May Have Nothing to Do With Weight Loss
An observational study of 47,199 patients with baseline cardiovascular disease in a U.S. EHR network found higher maximum semaglutide dose w…
A massive real-world study of over 47,000 heart patients suggests that semaglutide may protect the heart through direct biological effects —…
Meta-analysis finds liraglutide improves menstrual frequency and BMI in overweight women with PCOS
A Common Weight Loss Drug May Ease a Hidden Cause of Infertility
A systematic review and meta-analysis of 330 overweight or obese women with PCOS found liraglutide significantly increased menstrual frequen…
A common weight loss drug helps overweight women with PCOS restore regular periods and improve metabolic health.
Systematic review links neutrophil extracellular trap dysregulation to pregnancy complications
Web of White Blood Cells Linked to Pregnancy Risks
A systematic review of emerging evidence indicates that dysregulation of neutrophil extracellular trap (NET) formation and clearance is stro…
A sticky web of white blood cells meant to fight germs can instead trigger serious pregnancy risks like preeclampsia and preterm birth when …
FDA Approves Dapagliflozin and Metformin Hydrochloride Extended-Release Tablets for Type 2 Diabetes and Related Risks
FDA approves a new once-daily pill for type 2 diabetes that may also help protect the heart and kidneys.
The FDA has approved dapagliflozin and metformin hydrochloride extended-release tablets as an adjunct to diet and exercise to improve glycem…
A new once-daily pill for type 2 diabetes may protect the heart and kidneys from serious problems like heart attacks and worsening kidney di…
Oral quadruple therapy reduces HbA more than metformin uptitration in type 2 diabetes on triple therapy
When three diabetes pills aren't enough, does adding a fourth help more than increasing metformin?
A 24-week, multicenter RCT in 193 adults with type 2 diabetes (HbA 7.0-9.0%) on triple oral therapy compared adding a fourth oral agent vers…
When three diabetes pills fail to control blood sugar, adding a fourth medication lowered HbA1c better than simply increasing the metformin …
Phase 4 trial compares pioglitazone versus dapagliflozin add-on in type 2 diabetes
Trial compares two diabetes drug combinations but results are not yet available
A phase 4 randomized controlled trial in South Korea enrolled 133 participants with type 2 diabetes inadequately controlled by DPP-4 inhibit…
A completed trial in South Korea compared two three-drug combinations for type 2 diabetes, but results on blood sugar control are not yet av…
Offline peer support improves BMI and glucose in type 2 diabetes; hybrid support reduces HbA1c
Offline peer support linked to better weight and blood sugar in type 2 diabetes
A systematic review and meta-analysis of adults with type 2 diabetes found offline peer support significantly improved body-mass index and f…
In-person peer support for type 2 diabetes improved weight and blood sugar, while mixing online and offline help lowered long-term blood sug…
Metformin with standard therapy shows no significant survival benefit in gynecologic cancers
Does adding metformin to cancer treatment help women with gynecologic cancers?
A meta-analysis of 5 RCTs involving 705 patients with gynecologic malignancies found metformin combined with standard therapy did not signif…
Adding the diabetes drug metformin to standard cancer treatment did not help women with gynecologic cancers live longer or delay disease pro…
Phase 2 trial tests metformin with neoadjuvant radiochemotherapy for locally advanced rectal cancer
Could a common diabetes drug help people with rectal cancer respond better to treatment?
A Phase 2 trial (n=60) evaluated adding metformin to neoadjuvant radiochemotherapy (capecitabine + 50 Gy radiation) for locally advanced rec…
Adding a common diabetes pill to pre-surgery treatment for rectal cancer may help clear out cancer cells before the operation begins.