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Acute Appendicitis

7 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Acute Appendicitis

17 trials tracked for Acute Appendicitis: 5 in phase 3 or 4.

17Trials tracked
5Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 4 4 Phase 3 1 Phase 2 2 Other / NA 10
  1. Phase 4 Comparison of Medical and Surgical Treatment of Uncomplicated Acute Appendicitis in Children Completed
  2. Phase 4 Optimal Care of Complicated Appendicitis Completed
  3. Phase 4 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection Completed
  4. Phase 4 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI) Completed
  5. Phase 3 Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT Completed
  6. Phase 2 Antibiotic Instillation in Appendicitis Completed
Show 11 more trials
  1. Phase 2 The Role of Contrast Enhanced Ultrasound in Appendicitis Completed
  2. N/A Low vs. Standard Dose CT for Appendicitis Trial Completed
  3. N/A Magnetic Resonance Imaging (MRI) of Appendicitis in Children Completed
  4. N/A Laparoscopic Versus Open Appendectomy? Let the Patient Decide Completed
  5. N/A Probiotics and Antibiotic Associated Diarrhea in Pediatric Complicated Appendicitis Completed
  6. N/A Wound Infection Alexis Wound Retractor Completed
  7. N/A EHR-based Decision Support for Pediatric Acute Abdominal Pain in Emergency Care Completed
  8. N/A The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial Completed
  9. N/A Randomized Controlled Trial of a Patient Activation Tool in Pediatric Appendicitis (Antibiotics Alone vs. Appendectomy) Completed
  10. N/A Capillary Leak Index as a Prognostic Indicator for Post-Operative Abdominal Sepsis in Critically Ill Patients Completed
  11. N/A Influence of the Different Ways of Appendix Stump Closure on Patient Outcome in Laparoscopic Appendectomy Completed

Showing the 17 most-cited and recently-updated of 17 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Questions about Acute Appendicitis

What is the diagnostic accuracy of ultrasound for children with appendicitis?

Ultrasound is a key tool for diagnosing appendicitis in children, with point-of-care studies showing a sensitivity of about 86% and a specificity of about 90%.

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Which blood markers help doctors identify complicated acute appendicitis in patients with a retrospective study?

Doctors use blood markers like white blood cell counts, the neutrophil-to-lymphocyte ratio (NLR), and the systemic immune-inflammation index (SII) to identify complicated acute appendicitis, with combining these markers improving accuracy.

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How many adults with acute appendicitis needed surgery within 10 years after taking antibiotics?

About 44% of adults with uncomplicated acute appendicitis treated with antibiotics needed surgery within 10 years, mostly due to recurrence.

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What percentage of adults treated with antibiotics for acute appendicitis had recurrence after 10 years?

About 37.8% of adults treated with antibiotics for uncomplicated acute appendicitis had a recurrence within 10 years, and 44.3% eventually underwent appendectomy.

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