Adrenergic receptor signaling modulates pulmonary innate immunity and barrier integrity in acute lung injury
Understanding How Nerve Signals Influence Lung Health During Severe Respiratory Infections
This systematic review synthesizes the role of adrenergic receptors (ARs) as a molecular interface between the sympathetic nervous system an…
New research explores how specific nerve signals help control inflammation and protect the lungs during severe lung infections.
Shorter antibiotic courses may match longer ones for canine pneumonia, but evidence is weak
Shorter antibiotic courses work just as well as longer ones for dog pneumonia
This systematic review and meta-analysis of 74 dogs found no significant difference in treatment success between shorter (10-14 days) and lo…
A new analysis suggests shorter antibiotic courses may treat dog pneumonia just as well as longer ones, though evidence for cats is missing.
EBOV-specific gene signature identified in nonhuman primates and human cohorts with Ebola infection
New gene signature can spot Ebola infection in blood samples
This observational cohort study analyzed RNA-Seq data from nonhuman primates and human cohorts with Ebola virus infection and comparator inf…
Researchers found a 50-gene signature that reliably separates Ebola from other infections in blood tests, pointing to a future diagnostic to…
Mechanistic review discusses host-directed therapy for children with Long COVID and secondary bacterial pneumonia
Could monitoring specific blood markers help prevent long-term lung damage in kids with Long COVID?
This mechanistic review addresses Long COVID, Post-Acute Sequelae of SARS-CoV-2 infection, and secondary bacterial pneumonia in children.
Monitoring blood markers like ferritin and D-dimer could help doctors catch dangerous lung inflammation early in kids with Long COVID before…
Research across Pneumonia
Related studies from across the Pneumonia family.
EV-D68 infection may cause plastic bronchitis and severe pneumonia in pediatric patients
EV-D68 Infection Linked to Severe Lung Issues in Children
This case report and literature review describes a single 11-year-old girl with Enterovirus D68 infection leading to plastic bronchitis and …
A new case report identifies Enterovirus D68 as a potential cause of severe pneumonia and plastic bronchitis in children.
Short-course antibiotic therapy reduces medication non-adherence in children with non-severe community-acquired pneumonia
Short antibiotic courses may help children finish their full prescriptions
This meta-analysis of 10 trials (n = 8970) found that short-course antibiotic therapy (≤ 5 days) for non-severe pediatric community-acquired…
Shorter antibiotic courses for mild pneumonia in children may help them stay on track with their medication without reducing treatment succe…
Higher baseline Prognostic Nutritional Index reduces mortality risk in sepsis and pneumonia patients
Nutritional status helps predict survival in patients with severe infections
This meta-analysis of 28,757 patients with infectious diseases found that higher baseline Prognostic Nutritional Index (PNI) is associated w…
A high nutritional score at the start of treatment can help doctors identify which patients with sepsis or pneumonia are at the highest risk…
Omadacycline and baloxavir marboxil used in an 89-year-old with influenza A, psittacosis, and Klebsiella pneumonia
New drug combination helps elderly man with severe lung infections
This case report describes an 89-year-old man with influenza A, Chlamydia psittaci pneumonia, and Klebsiella pneumoniae who improved and was…
A combination of omadacycline and baloxavir marboxil helped an 89-year-old man recover from a complex, multi-organ infection in the ICU.
Autoantibody positivity and false-negative cytology can mask invasive mucinous adenocarcinoma in patients with IPAF
Lung cancer can mimic autoimmune lung disease in some patients
This case report describes a 78-year-old female with invasive mucinous adenocarcinoma and interstitial pneumonia with autoimmune features. T…
A new case shows how a rare lung cancer can look like an autoimmune disease, making it hard for doctors to tell them apart.
MRSA nares PCR does not cut vancomycin duration in ICU CAP
MRSA Testing Does Not Reduce Vancomycin Use in Pneumonia Patients
In a single-center randomized trial of 277 adult ICU patients with suspected community-acquired pneumonia, MRSA nares PCR testing did not si…
A trial of 277 ICU patients found that MRSA nasal swab testing did not reduce the amount of vancomycin used for pneumonia.
Physical frailty tops risk factors for pneumonia after esophagectomy, meta-analysis finds
Physical frailty and muscle loss increase pneumonia risk after surgery
This meta-analysis of 60 cohort studies in esophageal cancer patients undergoing esophagectomy identified physical frailty as the highest-ra…
Patients with esophageal cancer face a higher risk of pneumonia after surgery if they show signs of physical frailty or muscle loss.
Short-course ceftriaxone reduces hospital stay and adverse events in children with pneumonia
Shorter antibiotic courses may help children with pneumonia stay home
This randomized controlled trial of 200 children aged 1 to 14 years found that short-course ceftriaxone (5 to 7 days) resulted in shorter ho…
A new trial shows that a shorter course of ceftriaxone can reduce hospital stays and side effects for children with pneumonia.
Aerosolized liposomal amphotericin B provides strongest evidence for invasive pulmonary aspergillosis prophylaxis in high-risk patients
Aerosolized Amphotericin B Shows Promise for Lung Fungal Infections
This mini review synthesizes clinical experience regarding aerosolized antifungal therapies for various pulmonary fungal infections. It conc…
Aerosolized liposomal amphotericin B shows promise for preventing specific lung fungal infections in high-risk and immunocompromised patient…
mNGS achieves 85.83% pathogen detection rate in children with severe pneumonia compared to 49.97% for conventional methods
New Genetic Test Finds More Pneumonia Germs in Kids
This systematic review evaluates metagenomic next-generation sequencing (mNGS) for identifying pathogens in children with severe pneumonia. …
A new genetic test detects pneumonia-causing germs in kids more often than standard methods, which could lead to better treatment.
Inhaled antibiotics may improve lung function and microbiological eradication in cystic fibrosis and bronchiectasis
Inhaled Antibiotics May Improve Lung Health in Chronic Lung Conditions
This meta-analysis evaluated the efficacy of inhaled antibiotics for patients with cystic fibrosis, non-cystic fibrosis bronchiectasis, and …
Inhaled antibiotics may improve lung function and clear infections for people with cystic fibrosis and other chronic lung conditions.
Antibiotic exposure disrupts gut microbiota in 58% to 94% of critically ill children
Antibiotics and gut health in critically ill children
This narrative review examines antibiotic exposure in critically ill children in the PICU, reporting that 58% to 94% receive antibiotics, wh…
Common antibiotics used in intensive care can disrupt a child's gut health, increasing the risk of serious infections like pneumonia.