Plasma NfL levels elevated in bipolar and depressive disorders in UK Biobank cohort
Brain Scans Show Hidden Signals in Mental Health
A cohort study of 47,495 UK Biobank participants found plasma neurofilament light chain (NfL) levels were higher in bipolar disorder (d=0.20…
Blood tests now reveal hidden brain signals that distinguish depression from anxiety, offering clearer paths to the right treatment for mill…
Mental health syndemics reduce ART adherence and impair viral suppression in people living with HIV.
When HIV and Depression Collide, Treatment Suffers
This systematic review and meta-analysis of 32 studies involving people living with HIV (PLWH) examined the impact of mental health-related …
When depression, trauma, and poverty pile onto HIV, people struggle more to take their meds and keep the virus in check.
Social risk factors show larger effect sizes than polygenic risk scores for bipolar disorder in cohort study
What matters more for bipolar disorder: your genes or your life experiences?
A cohort study of 115,275 participants from the All of Us Research Program found that six social risk factors had larger effect sizes than p…
Social factors like stress and childhood trauma are more strongly linked to bipolar disorder than genetic risk, with high social burden some…
Protocol outlines target trial emulation for bipolar disorder treatments in patients with opioid use disorder
Study protocol compares bipolar disorder medications for people with opioid use disorder
This protocol describes a planned target trial emulation study using population-level administrative data from British Columbia and Ontario,…
People with bipolar disorder and opioid use disorder face higher risks, but a new plan will compare how well different medications work for …
FDA Approves Depakote (divalproex sodium) for Manic Episodes Associated with Bipolar Disorder
FDA approves Depakote for treating manic episodes in bipolar disorder.
The FDA approved Depakote (divalproex sodium) for the treatment of manic episodes associated with bipolar disorder. The approval was based o…
FDA approves Depakote for treating manic episodes in hospitalized adults with bipolar disorder, offering doctors a new option for managing a…
FDA Approves Depakote ER (divalproex sodium) for Acute Manic or Mixed Episodes in Bipolar Disorder
FDA approves a new once-daily pill for treating manic episodes in bipolar disorder.
The FDA has approved Depakote ER, an extended-release valproate, for the acute treatment of manic or mixed episodes associated with bipolar …
FDA approves a new once-daily pill for short-term treatment of severe manic episodes in adults with bipolar I disorder.
Meta-analysis identifies distinct and shared amygdala connectivity patterns in major depression and bipolar disorder
Do depression and bipolar disorder show different brain wiring patterns?
A voxel-wise meta-analysis of neuroimaging studies compared amygdala functional connectivity in patients with major depressive disorder and …
Brain scans show depression and bipolar disorder have different wiring in memory areas but share abnormalities in emotion control regions.
Transcriptomic meta-analysis in bipolar disorder identifies mitochondrial, synaptic, and inflammatory pathway genes
Gene analysis in bipolar disorder finds links to energy, inflammation, and signaling pathways
A meta-analysis of 917 brain and 638 blood samples from BD patients and controls found enrichment of genes involved in mitochondrial bioener…
Gene analysis reveals that bipolar disorder disrupts brain energy production, stress response, and inflammation pathways, pointing to specif…
Insomnia's association with cognitive function studied in 170 bipolar disorder outpatients
Study examines link between insomnia and thinking problems in bipolar disorder
An observational study examined 170 outpatients with bipolar disorder to assess insomnia's relationship with cognitive functioning. The abst…
People with bipolar disorder who struggle to sleep may also face thinking problems, though this study only shows a connection without provin…