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Home › Conditions › Cerebral Palsy

Cerebral Palsy

Part of Encephalopathy

14 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Cerebral Palsy

75 trials tracked for Cerebral Palsy: 12 in phase 3 or 4 and 2 with published results. The most-cited published study has 40 citations.

75Trials tracked
12Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 2 Phase 3 10 Phase 2 6 Phase 1 6 Other / NA 51
  1. Phase 3 Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability Completed · 40 cited
  2. Phase 3 Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsy Completed · 19 cited
  3. Phase 4 A Pilot Study of Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging Completed
  4. Phase 4 Peri-operative Use of a Pain Injection in Pediatric Patients With Cerebral Palsy Completed
  5. Phase 3 Dysport® Pediatric Lower Limb Spasticity Study Completed
  6. Phase 3 Dysport® Pediatric Lower Limb Spasticity Follow-on Study Completed
Show 44 more trials
  1. Phase 3 BOTOX® Treatment in Pediatric Lower Limb Spasticity Completed
  2. Phase 3 BOTOX® Treatment in Pediatric Upper Limb Spasticity Completed
  3. Phase 3 BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity Completed
  4. Phase 3 BOTOX® Open-Label Treatment in Pediatric Lower Limb Spasticity Completed
  5. Phase 3 Effect of Dysport Injections on Energy Expenditure and Walking Efficiency in Children With Cerebral Palsy Completed
  6. Phase 3 Safety and Efficacy Study of Oral Glycopyrrolate Liquid for the Treatment of Pathologic (Chronic Moderate to Severe) Drooling in Pediatric Patients 3 to 18 Years of Age With Cerebral Palsy or Other Neurologic Conditions Completed
  7. Phase 2 Endermotherapy for Children With Developmental Disabilities Completed
  8. Phase 2 Safety and Effectiveness of Banked Cord Blood or Bone Marrow Stem Cells in Children With Cerebral Palsy (CP). Completed
  9. Phase 2 Effect of Power Wheelchairs on the Development and Function of Young Children With Severe Physical Disabilities Completed
  10. Phase 2 A Study of UCB and MSCs in Children With CP: ACCeNT-CP Completed
  11. Phase 2 P300 Brain Computer Interface Keyboard to Operate Assistive Technology Completed
  12. Phase 2 A Randomized Study of Autologous Umbilical Cord Blood Reinfusion in Children With Cerebral Palsy Completed
  13. Phase 1 Telehealth Virtual Reality Gaming on Cardiometabolic Health Among Youth With Cerebral Palsy Completed
  14. Phase 1 Development of a Robotic Ankle Assist Device Completed
  15. Phase 1 Testing an Adjustable Ankle Orthosis During Walking in Cerebral Palsy Completed
  16. Phase 1 Piloting Movement-to-Music With Arm-based Sprint-Intensity Interval Training Among Children With Physical Disabilities Completed
  17. Phase 1 Evaluating Wearable Robotic Assistance on Gait Completed
  18. Phase 1 Extending taVNS Paired With Infant CIMT Into a Home-Based Setting Completed
  19. N/A Respiratory Exacerbation Plans for Action and Care Transitions for Children With Severe CP Completed
  20. N/A Early Powered Mobility for Toddlers With Cerebral Palsy Using the Permobil® Explorer Mini and a Modified Ride-On Car Completed
  21. N/A Study Assessing High-Frequency Chest Wall Oscillation (HFCWO) in Preventing Pulmonary Exacerbations Completed
  22. N/A Evaluation of Project TEAM (Teens Making Environmental and Activity Modifications) Completed
  23. N/A Intelligent and Adaptive Control Applied to Powered Walkers Completed
  24. N/A Physical and Social Benefits of Multi-Player Interactive Computer Play Games in Youth With Cerebral Palsy Completed
  25. N/A Constraint-induced Movement Therapy (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegic Cerebral Palsy Completed
  26. N/A A Pilot Study of Hand Function in Children With Cerebral Palsy Undergoing Intensive Neurophysiological Rehabilitation Completed
  27. N/A Clinical Utility of Pediatric Whole Exome Sequencing Completed
  28. N/A Cerebral Palsy Early Mobility Training Completed
  29. N/A SmarToyGym: Smart Detection of Atypical Toy-oriented Actions in At-risk Infants Completed
  30. N/A Orthotics in Ambulatory Cerebral Palsy Completed
  31. N/A Intensive Unimanual (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegia Completed
  32. N/A Use of Low Cost Prostheses to Improve Upper Extremity Function in Children With Cerebral Palsy Completed
  33. N/A Effects of Hippotherapy on Physical Fitness and Attention in Cerebral Palsy Completed
  34. N/A Managing Post-operative Pain in Children With Cerebral Palsy Using a Pain Pump Completed
  35. N/A Precision Gait Retraining for Children With Cerebral Palsy Completed
  36. N/A Therapeutic Dance Intervention for Children With Cerebral Palsy Completed
  37. N/A Effect of Trunk Stabilization Exercises on Quality of Life and Communication in Cerebral Palsy Completed
  38. N/A Seating System for Scoliosis in Non-ambulatory Children With Cerebral Palsy: A Pilot Randomized Controlled Trial Completed
  39. N/A Dynamic Gait Index in Hemiplegic Cerebral Palsy Completed
  40. N/A The TOBY Children Study Completed
  41. N/A Quantifying Patient-Specific Changes in Neuromuscular Control in Cerebral Palsy Completed
  42. N/A A Study of Neurophysiologically Based Occupational Therapy Intervention (NBOTI) for Feeding in the NCCU. Completed
  43. N/A Allogenic Umbilical Cord Blood and Erythropoietin Combination Therapy for Cerebral Palsy Completed
  44. N/A NEO Rehab Program for Premature Infants at Risk for Cerebral Palsy Completed

Showing the 50 most-cited and recently-updated of 75 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Vaccinated children with cerebral palsy show better motor, communication function in cohort study
Pediatrics Cohort
Vaccinated children with cerebral palsy show better motor, communication function in cohort study Could vaccines help children with cerebral palsy move and communicate better?
A bidirectional cohort study of 484 children with cerebral palsy found vaccinated children had significantly better motor function (p=0.001)…
Children with cerebral palsy who got routine vaccines scored better on motor and communication tests than unvaccinated peers in a hospital s…
Frontiers Apr 4, 2026
Video feedback intervention shows significant effects on maternal sensitivity in cerebral palsy dyads
Pediatrics RCT
Video feedback intervention shows significant effects on maternal sensitivity in cerebral palsy dyads Video feedback parenting program shows promise for mothers of children with cerebral palsy
A small RCT of 40 mother-child dyads where the child has cerebral palsy found that the VIPP-CP intervention had significant effects on speci…
A video feedback program helped mothers of children with cerebral palsy become more supportive, sensitive, and encouraging during play.
Apr 3, 2026

Research across Encephalopathy

Related studies from across the Encephalopathy family.

First case report links zonisamide to homicidal ideation in epilepsy patient
Psychiatry Sys. Review
First case report links zonisamide to homicidal ideation in epilepsy patient First case report links zonisamide to homicidal thoughts in an epilepsy patient
A case report and literature review describes a patient with epilepsy who developed homicidal ideation during zonisamide uptitration. Sympto…
A patient developed homicidal thoughts after taking zonisamide. This rare case highlights a serious psychiatric side effect of the drug that…
Frontiers Jun 1, 2026
Risk-stratified aeromedical certification protocol assessed in 22 military pilots with cerebral cavernous malformations
Primary Care & Family Medicine Cohort
Risk-stratified aeromedical certification protocol assessed in 22 military pilots with cerebral cavernous malformations Military pilots with brain lesions were assessed for flight safety under a new protocol
This retrospective cohort study evaluated a risk-stratified aeromedical certification protocol in 22 military pilots with cerebral cavernous…
Military pilots with stable brain lesions were cleared to fly without restrictions after a personalized safety review found no neurological …
Frontiers Apr 16, 2026

Questions about Cerebral Palsy

How do prenatal and neonatal factors affect the risk of cerebral periventricular leukomalacia in preterm infants?

Prenatal infections, low gestational age, and neonatal factors like low cerebral blood flow and oxygen levels increase the risk of cystic periventricular leukomalacia (cPVL) in preterm infants, which can lead to cerebral palsy.

Full answer →
Which surgical or neuromodulation options are best for functional outcomes in ambulatory children with cerebral palsy?

For ambulatory children with cerebral palsy, selective dorsal rhizotomy (SDR) is often considered best for spastic diplegia, while deep brain stimulation (DBS) helps dystonia; intrathecal baclofen (ITB) and peripheral neurectomies are other options. Choice depends on individual s

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What genetic factors are linked to the specific characteristics of cerebral palsy in children?

Genetic factors are linked to cerebral palsy characteristics, with 12.2% of patients in a large US registry having a genetic etiology, and genetic causes are associated with specific motor function levels and movement types.

Full answer →