Aerobic and strength training reduce fatigue in multiple sclerosis patients
Aerobic or strength training eases MS fatigue, trial finds
This randomized effectiveness trial in 62 persons with multiple sclerosis and fatigue found that 8 weeks of aerobic training, strength train…
A small trial finds that aerobic and strength training each reduce fatigue in MS, with no clear winner among exercise types.
Frexalimab study validates PROMIS-Fatigue-MS-8a and MSIS-29v2 in relapsing multiple sclerosis patients
New tools reliably measure fatigue in multiple sclerosis
This Phase 2 trial assessed psychometric validation of PROMIS-Fatigue-MS-8a and MSIS-29v2 in adults with relapsing multiple sclerosis.
Two questionnaires accurately track fatigue in relapsing MS, offering a new way to measure treatment benefits in trials.
Sleep efficiency improved with mindfulness in multiple sclerosis patients according to a meta-analysis
Mindfulness and Melatonin May Help Sleep in Multiple Sclerosis
This systematic review and meta-analysis evaluated non-pharmacologic and pharmacologic interventions for sleep in people with multiple scler…
A review of ten studies suggests mindfulness, melatonin, and other therapies may improve sleep for people with multiple sclerosis, though mo…
Meta-analysis shows reduced stress-induced autonomic responses in people with multiple sclerosis compared to controls
People with MS show reduced autonomic responses to stress compared to controls
This meta-analysis reviews fourteen studies examining autonomic responses to emotional or stress-related stimuli in people with multiple scl…
A meta-analysis of fourteen studies found that people with multiple sclerosis have lower stress-induced autonomic responses than healthy con…
Global MS burden in women of childbearing age rises 48% from 1990 to 2021
Multiple sclerosis rates rose sharply in women of childbearing age from 1990 to 2021
A global cohort analysis of 204 countries found that multiple sclerosis incidence in women aged 15–49 rose 48% from 1990 to 2021, with preva…
Multiple sclerosis cases and deaths increased among women of childbearing age globally, though disability years dropped slightly.
Review of active therapeutic interventions in 255 people with multiple sclerosis undergoing inpatient rehabilitation
Rehab goals reached by most people with multiple sclerosis during active therapy
This multicentre single-arm pragmatic clinical trial review examines active therapeutic interventions for people with multiple sclerosis in …
Over 88% of people with multiple sclerosis achieved their therapy goals during active rehabilitation, showing significant mobility improveme…
Case report and literature review of severe adverse reactions following pucotenlimab treatment
New drug treatment linked to severe neurological reactions
This case report and literature review describes severe adverse reactions following treatment with pucotenlimab in a patient with advanced b…
A single patient facing advanced breast cancer experienced life-threatening neurological symptoms after receiving the drug pucotenlimab.
Narrative review discusses multi-target strategies for multiple sclerosis progression
New MS research points to five key targets for better treatment options soon
This narrative review addresses multiple sclerosis and suggests that existing animal models do not fully capture human disease complexity.
New research reveals five specific body processes that drive multiple sclerosis damage and could lead to better treatments for patients soon
Mini-review explores oxidized mannan-conjugated MOG peptide for multiple sclerosis immunotherapy
New MS Treatment Could Teach Immune System To Stop Attack
This mini-review summarizes preclinical evidence on oxidized mannan-conjugated MOG peptide (OM-MOG35-55) for multiple sclerosis.
A new treatment for multiple sclerosis may teach the immune system to stop attacking nerves without shutting down protection or causing majo…
Plasma cytokines and CSF ROS measured in MS phenotypes show associations with disability and cognition
New Clues Explain Why Some MS Patients Lose Mobility Without Inflammation
This multicenter cohort study measured plasma cytokines and CSF ROS in participants with MS and other neurological disorders.
A new study reveals that in a form of progressive MS without active inflammation, brain stress signals—not inflammation—predict disability a…
Composite Endpoints Show Weaker Treatment Effects Than EDSS Alone in Multiple Sclerosis Trials
Adding walk tests to MS disability scores actually hides treatment benefits
This post-hoc analysis of ten phase III trials involving 9369 patients with relapsing-remitting and progressive multiple sclerosis evaluated…
Adding walk tests to standard disability scores actually hides treatment benefits in multiple sclerosis trials.
Narrative review notes lack of comprehensive synthesis on antioxidant strategies for multiple sclerosis
New MS Strategy Targets Hidden Nerve Damage Cycle
This narrative review examines antioxidant-based therapeutic strategies for multiple sclerosis.
Scientists are finding new ways to stop the cycle that destroys nerves in MS.