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Home › Conditions › Down Syndrome

Down Syndrome

Part of Trisomy 21

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Down Syndrome

35 trials tracked for Down Syndrome: 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 100 citations.

35Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 2 Phase 3 2 Phase 2 9 Phase 1 2 Other / NA 20
  1. Phase 3 Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Completed · 100 cited
  2. Phase 3 Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children Completed · 14 cited
  3. Phase 4 Fluoxetine Treatment of Depression in Down Syndrome Completed
  4. Phase 4 Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down Syndrome Completed
  5. Phase 2 Rivastigmine Study in Adolescents With Down Syndrome Completed
  6. Phase 2 A 4-Week Safety Study of Oral ELND005 in Young Adults With Down Syndrome Without Dementia Completed
Show 29 more trials
  1. Phase 2 Down Syndrome Memantine Follow-up Study Completed
  2. Phase 2 Nicotine Treatment of Cognitive Decline in Down Syndrome Completed
  3. Phase 2 Medications for Obstructive Sleep Apnea In Children With Down Syndrome Completed
  4. Phase 2 Tofacitinib for Immune Skin Conditions in Down Syndrome Completed
  5. Phase 2 Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (HCl) (Aricept) In Treating Cognitive Dysfunction Exhibited By Children With Down Syndrome Completed
  6. Phase 2 Phase II Study of Florbetaben (BAY94-9172) PET Imaging for Detection/Exclusion of Cerebral β-amyloid. Completed
  7. Phase 2 Dilated Versus Non-Dilated Wavefront Corrections for Patients With Down Syndrome Completed
  8. Phase 1 Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults With Down Syndrome Completed
  9. Phase 1 Investigation of the Safety of Intranasal Glulisine in Down Syndrome Completed
  10. N/A Assessing Malleability of Spatial Abilities in Down Syndrome Completed
  11. N/A Promoting Health Through Parent Empowerment and the Activation of Routines (PrO-PEAR) Completed
  12. N/A GameSquad for Adults With Down Syndrome Completed
  13. N/A Balance Bike Training in Down Syndrome Completed
  14. N/A Treatment Trial of Subclinical Hypothyroidism in Down Syndrome Completed
  15. N/A An Online Health Tool About Down Syndrome: Down Syndrome Clinic to You Completed
  16. N/A A Pilot Study to Evaluate the Hypoglossal Nerve Stimulator in Adolescents With Down Syndrome and Obstructive Sleep Apnea Completed
  17. N/A Investigating the Experience of Living With Down Syndrome and Obstructive Sleep Apnea Syndrome (Stage 1) Completed
  18. N/A Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome Completed
  19. N/A The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down Syndrome Completed
  20. N/A Weight Management for Adolescents With IDD Completed
  21. N/A Blood Flow Regulation in Individuals With Down Syndrome - Training Study Completed
  22. N/A Treadmill Training and Orthotic Use in Infants With Down Syndrome Completed
  23. N/A Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome Completed
  24. N/A Strategies for Teaching Verbs Completed
  25. N/A Promotion of Physical Activity in Adolescents With Intellectual and Developmental Disabilities Completed
  26. N/A Gait in Children With Down Syndrome While Wearing Orthoses Completed
  27. N/A Use of Partial Body Weight Support Play Environment to Encourage Mobility and Exploration in Infants With Down Syndrome Completed
  28. N/A Developing a Down Syndrome Health Instrument Completed
  29. N/A Down Syndrome Metabolic Health Study Completed

Showing the 35 most-cited and recently-updated of 35 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Review of a case of Down syndrome T-ALL with complex karyotype and treatment response
Pediatrics Sys. Review
Review of a case of Down syndrome T-ALL with complex karyotype and treatment response Boy with Down syndrome beats rare leukemia after tailored chemo
This narrative review and case report describes a 7-year-old boy with Down syndrome and T-cell acute lymphoblastic leukemia treated with AIE…
A 7-year-old with Down syndrome and a rare T-cell leukemia achieved remission after tailored chemotherapy, despite severe complications.
Frontiers May 18, 2026
Oral health factors in 500 Chinese children with special needs show high caries prevalence and associations with hygiene
Palliative Care Cohort
Oral health factors in 500 Chinese children with special needs show high caries prevalence and associations with hygiene Three in Four Special Needs Kids Have Cavities by Age 17
This retrospective cross-sectional analysis evaluated oral health in 500 children with special health care needs in Nanjing, China.
A careful look at 500 children's dental records points to clear, fixable steps caregivers can start using this week.
Frontiers Apr 13, 2026