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Home › Conditions › Endometriosis

Endometriosis

Subtypes of Endometriosis

Deep infiltrating endometriosis 1 Diaphragmatic Endometriosis 1 Ovarian endometriosis cyst 1

20 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Endometriosis

46 trials tracked for Endometriosis: 15 in phase 3 or 4 and 12 with published results. The most-cited published study has 544 citations.

46Trials tracked
15Phase 3 & 4
0Recruiting
12With published results
Phase distribution
Phase 4 6 Phase 3 9 Phase 2 18 Phase 1 1 Other / NA 12
  1. Phase 4 Resveratrol for Pain Due to Endometriosis Completed · 544 cited
  2. Phase 3 A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed · 497 cited
  3. Phase 3 A Global Phase 3 Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed · 495 cited
  4. Phase 3 SPIRIT EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Endometriosis-Associated Pain Completed · 52 cited
  5. Phase 3 Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain. Completed · 41 cited
  6. Phase 3 A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain Completed · 36 cited
Show 40 more trials
  1. Phase 3 Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Adults With Moderate to Severe Endometriosis-Associated Pain Completed · 31 cited
  2. Phase 3 Global Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Women With Moderate to Severe Endometriosis-associated Pain Completed · 28 cited
  3. Phase 4 Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF Completed · 19 cited
  4. Phase 4 Chronic Pain Risk Associated With Menstrual Period Pain Completed · 9 cited
  5. Phase 3 Study to Compare the Oestradiol Suppression, Clinical Efficacy and Safety of Two Formulations of Triptorelin (Triptorelin Pamoate PR 3-month and Triptorelin Acetate PR 1-month) in Chinese Subjects With Endometriosis Completed · 6 cited
  6. Phase 3 Extension to Study on Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain (EDELWEISS 6) Completed · 1 cited
  7. Phase 4 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Completed
  8. Phase 4 Ulipristal for Endometriosis-related Pelvic Pain Completed
  9. Phase 4 The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis. Completed
  10. Phase 2 Evaluation of Endometriosis With 18F-fluoroestradiol PET / MRI Completed
  11. Phase 2 Quinagolide Vaginal Ring on Lesion Reduction Assessed by MRI in Women With Endometriosis/Adenomyosis Completed
  12. Phase 2 A Study of Pharmacokinetic/Pharmacodynamic Profile of Orally Administered Leuprolide in Healthy Female Volunteers Completed
  13. Phase 2 A Study to Assess the Efficacy and Safety of OBE2109 in Subjects With Endometriosis Completed
  14. Phase 2 Bay98-7196, Dose Finding / POC Study Completed
  15. Phase 2 Dopamine Receptor Agonist Therapy for Pain Relief in Women Suffering From Endometriosis: A Pilot Study Completed
  16. Phase 2 Efficacy and Safety Study of Elagolix Versus Placebo or Leuprorelin Acetate in Endometriosis Completed
  17. Phase 2 A Study to Assess the Efficacy and Safety of HMI-115 in Subjects With Endometriosis-Associated Pain Completed
  18. Phase 2 BGS649 Monotherapy in Moderate to Severe Endometriosis Patients Completed
  19. Phase 2 Botulinum Toxin for Pelvic Pain in Women With Endometriosis Completed
  20. Phase 2 The Effect of Hormonal Add-Back Therapy in Adolescents Treated With a GnRH Agonist for Endometriosis: A Randomized Trial Completed
  21. Phase 2 A Study to Investigate Efficacy and Safety of OG-6219 BID in 3 Dose Levels Compared With Placebo in Participants Aged 18 to 49 With Moderate to Severe Endometriosis-related Pain Completed
  22. Phase 2 Assessment and Prevention of Pain During Ovarian Stimulation in Patients With Endometriosis Completed
  23. Phase 2 Elagolix Versus Subcutaneous Depot Medroxyprogesterone Acetate for the Treatment of Endometriosis Completed
  24. Phase 2 Safety and Efficacy of Telapristone Acetate (Proellex®) in the Treatment of Pre-Menopausal Women With Confirmed, Symptomatic Endometriosis Completed
  25. Phase 2 Effect of Pre-operative Depo Medroxyprogesterone Acetate on Serum Anti-mullerian Hormone Level After Laparoscopic Ovarian Cystectomy of Endometriomas Completed
  26. Phase 2 Elagolix for Fertility Enhancement Clinical Trial Completed
  27. Phase 2 Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments Completed
  28. Phase 1 A Phase 1 Study to Evaluate the Effects of Fluconazole and Atorvastatin on the Pharmacokinetics of TAK-385 in Healthy Subjects Completed
  29. N/A A Survey on Efficacy and Safety in Patients With Endometriosis Completed
  30. N/A Endometriosis Group Care Completed
  31. N/A Dyspareunia and Central Sensitization Completed
  32. N/A An AHEI Dietary Intervention to Reduce Pain in Women With Endometriosis Completed
  33. N/A GnRH-a and Pregnancy Rate in In Vitro Fertilization (IVF) Cycles. Completed
  34. N/A Enriched Environments in Endometriosis Completed
  35. N/A Novel Web-based, Self-directed Intervention for Chronic Pelvic Pain Completed
  36. N/A The Association Between Endometriosis, Obesity and nesfatin1 Completed
  37. N/A Ultravision™ System to Facilitate Low Impact Laparoscopic Surgery for Endometriosis Completed
  38. N/A Effects of Intravenous Lidocaine on Endometriosis Pain Completed
  39. N/A Laparoscopy vs. Robotic Surgery for Endometriosis (LAROSE): a Prospective Randomized Controlled Trial Completed
  40. N/A A Comparison of Narrow Band Imaging (NBI) and Standard White Light Laparoscopy to Detect Endometriosis Completed

Showing the 46 most-cited and recently-updated of 46 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Endometriosis: what the trials found

Several GnRH antagonists and agonists have been evaluated for the management of endometriosis-related pain. Elagolix demonstrated significant improvements in both dysmenorrhea (DYS) and non-menstrual pelvic pain (NMPP) at 3 months compared to placebo, with statistically significant reductions in Numeric Rating Scale (NRS) scores [14, 15, 19, 20]. Linzagolix showed a significant proportion of responders for dysmenorrhea at month 3 17, while relugolix demonstrated high responder rates for both DYS and NMPP at weeks 52 and 104 16.

Hormonal treatments including estradiol/norethindrone acetate showed statistically significant improvements in DYS and NMPP outcomes at months 6 and 12 18. Triptorelin pamoate was shown to effectively achieve castrated status (E2 levels ≤184 Pmol/L or 50 pg/mL) by week 12 21.

Cyclic microgestin 1/20 showed a statistically significant reduction in bladder pain sensitivity from baseline, though changes in pelvic hyperalgesia and cortical activity were not significantly different from baseline 10. Ulipristal was associated with a statistically significant reduction in pelvic pain 11.

Recent results — preliminary, needs further review

  • OG-6129 showed mean overall pelvic pain score reductions of -1.5 to -2.0 by treatment cycle 3 1.
  • A 5% lidocaine/5 mg/ml 0.02% estradiol compound cream did not significantly change pain scores during the tampon test or on the SF-MPQ, but showed a significant improvement in self-reported physical health via SF-12 2.
  • Placebo oral tablets were compared against letrozole; however, no significant difference was found in the delta of endometriosis pain scores between patients receiving placebo and those with no endometriosis 3.
  • Peer Empowered Endometriosis Pain Support (PEEPS) 6 and 'My Pelvic Plan' website interventions were studied but did not show statistically significant differences in PROMIS pain interference, intensity, or self-efficacy scores compared to other groups 7.

For the clinician treating this condition

  • Elagolix, linzagolix, and relugolix are established options for reducing both dysmenorrhea and non-menstrual pelvic pain.
  • Estradiol/norethindrone acetate and triptorelin pamoate provide established pathways for managing symptoms or achieving hormonal castration status.
  • Cyclic microgestin 1/20 is associated with reduced bladder pain sensitivity, though its impact on hyperalgesia parameters is not statistically confirmed.

AI synthesis of 11 cited trials, updated Jun 25, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Narrative review links lactylation modification to gynecological disease pathogenesis and potential therapy
OB/GYN & Women's Health Meta-analysis
Narrative review links lactylation modification to gynecological disease pathogenesis and potential therapy New metabolic switch could help treat difficult gynecological conditions
This narrative review addresses the lack of systematic analysis on lactylation modification in gynecological diseases. The authors synthesiz…
A new cellular switch that uses energy to control genes might one day help doctors treat difficult gynecological conditions like endometrios…
Frontiers May 4, 2026
Systematic review of induction methods for pelvic inflammatory disease animal models
OB/GYN & Women's Health Sys. Review
Systematic review of induction methods for pelvic inflammatory disease animal models New animal models reveal hidden causes of pelvic pain
This systematic review evaluates various methods used to construct animal models for pelvic inflammatory disease. The authors categorize ind…
Chronic pelvic pain affects millions of women, and new research reveals how animal models are uncovering hidden triggers of pelvic inflammat…
Frontiers May 2, 2026
GWAS meta-analysis identifies genetic risk loci for female genital tract polyps in women
Genetics & Precision Medicine Meta-analysis
GWAS meta-analysis identifies genetic risk loci for female genital tract polyps in women New DNA clues link common gynecological issues to endometriosis and cancer risks
This GWAS meta-analysis examined 48,400 cases and 477,134 controls across four biobanks to identify risk loci for female genital tract polyp…
A massive DNA study of nearly half a million women reveals genetic links between common gynecological polyps, endometriosis, fibroids, and e…
medRxiv Apr 18, 2026
Ultrasound-guided interventional therapy shows higher effectiveness and fewer adverse reactions than laparoscopic cyst resection for ovarian endometriosis cysts
Oncology Meta-analysis
Ultrasound-guided interventional therapy shows higher effectiveness and fewer adverse reactions than laparoscopic cyst resection for ovarian endometriosis cysts Ultrasound-guided therapy may work better and safer than surgery for ovarian cysts
This meta-analysis evaluated ultrasound-guided interventional therapy versus laparoscopic cyst resection in patients with ovarian endometrio…
Ultrasound-guided therapy may work better and safer than surgery for ovarian cysts, offering less pain and faster recovery for women.
Apr 16, 2026
Adenomyosis localization affects infertility and pregnancy outcomes in women with intrinsic or extrinsic disease
OB/GYN & Women's Health Meta-analysis
Adenomyosis localization affects infertility and pregnancy outcomes in women with intrinsic or extrinsic disease Does where adenomyosis grows in your uterus change your chances of getting pregnant?
This narrative systematic review analyzed nine observational studies involving women with intrinsic or extrinsic adenomyosis.
Adenomyosis location matters: outer growth links to infertility while inner growth connects to pregnancy loss, showing the disease pattern c…
Frontiers Apr 9, 2026
VATS and hormonal therapy for diaphragmatic endometriosis in a 42-year-old woman with hepatic herniation
Rheumatology Sys. Review
VATS and hormonal therapy for diaphragmatic endometriosis in a 42-year-old woman with hepatic herniation Can surgery alone fix rare chest pain caused by endometriosis, or is a team approach needed?
This case report and literature review describes a 42-year-old woman with diaphragmatic endometriosis, hepatic herniation, and catamenial pn…
A 42-year-old woman's rare chest pain from endometriosis required both surgery and hormones, proving that surgical repair alone may not be e…
Frontiers Apr 9, 2026
Mendelian randomization links genetic endometriosis liability to increased placenta praevia risk
OB/GYN & Women's Health Meta-analysis
Mendelian randomization links genetic endometriosis liability to increased placenta praevia risk Does endometriosis raise pregnancy risks? A genetic link points to one specific danger
A Mendelian randomization meta-analysis using summary-level GWAS data found genetic liability to endometriosis was robustly associated with …
A woman's genetic risk for endometriosis directly increases the chance of placenta praevia, a dangerous condition where the placenta grows t…
medRxiv Apr 8, 2026
Qualitative study reveals divergent perceptions of hormonal therapy efficacy in endometriosis management
OB/GYN & Women's Health
Qualitative study reveals divergent perceptions of hormonal therapy efficacy in endometriosis management Endometriosis patients and doctors often disagree on what makes treatment effective
A qualitative study of 20 endometriosis patients and 13 healthcare professionals found divergent perceptions of hormonal treatment efficacy.
Endometriosis patients seek pain relief while doctors prioritize stopping periods, creating a communication gap that adds mental burden to b…
medRxiv Apr 8, 2026

Questions about Endometriosis

Does exposure to BPA increase my risk of developing endometriosis based on recent studies?

Yes, recent meta-analyses show BPA exposure is linked to a higher risk of endometriosis, with odds ratios of 1.36 and 1.82.

Full answer →