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Home › Conditions › Endometriosis

Endometriosis

Subtypes of Endometriosis

Deep infiltrating endometriosis 1 Diaphragmatic Endometriosis 1 Ovarian endometriosis cyst 1

14 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Endometriosis

46 trials tracked for Endometriosis: 15 in phase 3 or 4 and 12 with published results. The most-cited published study has 539 citations.

46Trials tracked
15Phase 3 & 4
0Recruiting
12With published results
Phase distribution
Phase 4 6 Phase 3 9 Phase 2 18 Phase 1 1 Other / NA 12
  1. Phase 4 Resveratrol for Pain Due to Endometriosis Completed · 539 cited
  2. Phase 3 A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed · 491 cited
  3. Phase 3 A Global Phase 3 Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed · 489 cited
  4. Phase 3 SPIRIT EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Endometriosis-Associated Pain Completed · 50 cited
  5. Phase 3 Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain. Completed · 38 cited
  6. Phase 3 A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain Completed · 36 cited
Show 40 more trials
  1. Phase 3 Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Adults With Moderate to Severe Endometriosis-Associated Pain Completed · 31 cited
  2. Phase 3 Global Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Women With Moderate to Severe Endometriosis-associated Pain Completed · 27 cited
  3. Phase 4 Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF Completed · 19 cited
  4. Phase 4 Chronic Pain Risk Associated With Menstrual Period Pain Completed · 8 cited
  5. Phase 3 Study to Compare the Oestradiol Suppression, Clinical Efficacy and Safety of Two Formulations of Triptorelin (Triptorelin Pamoate PR 3-month and Triptorelin Acetate PR 1-month) in Chinese Subjects With Endometriosis Completed · 6 cited
  6. Phase 3 Extension to Study on Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain (EDELWEISS 6) Completed · 1 cited
  7. Phase 4 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Completed
  8. Phase 4 Ulipristal for Endometriosis-related Pelvic Pain Completed
  9. Phase 4 The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis. Completed
  10. Phase 2 Evaluation of Endometriosis With 18F-fluoroestradiol PET / MRI Completed
  11. Phase 2 Quinagolide Vaginal Ring on Lesion Reduction Assessed by MRI in Women With Endometriosis/Adenomyosis Completed
  12. Phase 2 A Study of Pharmacokinetic/Pharmacodynamic Profile of Orally Administered Leuprolide in Healthy Female Volunteers Completed
  13. Phase 2 A Study to Assess the Efficacy and Safety of OBE2109 in Subjects With Endometriosis Completed
  14. Phase 2 Bay98-7196, Dose Finding / POC Study Completed
  15. Phase 2 Dopamine Receptor Agonist Therapy for Pain Relief in Women Suffering From Endometriosis: A Pilot Study Completed
  16. Phase 2 Efficacy and Safety Study of Elagolix Versus Placebo or Leuprorelin Acetate in Endometriosis Completed
  17. Phase 2 A Study to Assess the Efficacy and Safety of HMI-115 in Subjects With Endometriosis-Associated Pain Completed
  18. Phase 2 BGS649 Monotherapy in Moderate to Severe Endometriosis Patients Completed
  19. Phase 2 Botulinum Toxin for Pelvic Pain in Women With Endometriosis Completed
  20. Phase 2 The Effect of Hormonal Add-Back Therapy in Adolescents Treated With a GnRH Agonist for Endometriosis: A Randomized Trial Completed
  21. Phase 2 A Study to Investigate Efficacy and Safety of OG-6219 BID in 3 Dose Levels Compared With Placebo in Participants Aged 18 to 49 With Moderate to Severe Endometriosis-related Pain Completed
  22. Phase 2 Assessment and Prevention of Pain During Ovarian Stimulation in Patients With Endometriosis Completed
  23. Phase 2 Elagolix Versus Subcutaneous Depot Medroxyprogesterone Acetate for the Treatment of Endometriosis Completed
  24. Phase 2 Safety and Efficacy of Telapristone Acetate (Proellex®) in the Treatment of Pre-Menopausal Women With Confirmed, Symptomatic Endometriosis Completed
  25. Phase 2 Effect of Pre-operative Depo Medroxyprogesterone Acetate on Serum Anti-mullerian Hormone Level After Laparoscopic Ovarian Cystectomy of Endometriomas Completed
  26. Phase 2 Elagolix for Fertility Enhancement Clinical Trial Completed
  27. Phase 2 Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments Completed
  28. Phase 1 A Phase 1 Study to Evaluate the Effects of Fluconazole and Atorvastatin on the Pharmacokinetics of TAK-385 in Healthy Subjects Completed
  29. N/A A Survey on Efficacy and Safety in Patients With Endometriosis Completed
  30. N/A Endometriosis Group Care Completed
  31. N/A Dyspareunia and Central Sensitization Completed
  32. N/A An AHEI Dietary Intervention to Reduce Pain in Women With Endometriosis Completed
  33. N/A GnRH-a and Pregnancy Rate in In Vitro Fertilization (IVF) Cycles. Completed
  34. N/A Enriched Environments in Endometriosis Completed
  35. N/A Novel Web-based, Self-directed Intervention for Chronic Pelvic Pain Completed
  36. N/A The Association Between Endometriosis, Obesity and nesfatin1 Completed
  37. N/A Ultravision™ System to Facilitate Low Impact Laparoscopic Surgery for Endometriosis Completed
  38. N/A Effects of Intravenous Lidocaine on Endometriosis Pain Completed
  39. N/A Laparoscopy vs. Robotic Surgery for Endometriosis (LAROSE): a Prospective Randomized Controlled Trial Completed
  40. N/A A Comparison of Narrow Band Imaging (NBI) and Standard White Light Laparoscopy to Detect Endometriosis Completed

Showing the 46 most-cited and recently-updated of 46 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Gut microbiota dysbiosis shows strong observational link to endometriosis in reproductive-aged women
OB/GYN & Women's Health Sys. Review
Gut microbiota dysbiosis shows strong observational link to endometriosis in reproductive-aged women Gut bacteria linked to endometriosis, review finds
This narrative review examines the association between gut microbiota dysbiosis and endometriosis in reproductive-aged women. The authors re…
A review of studies finds a strong link between gut bacteria imbalances and endometriosis, but can't prove cause and effect.
Frontiers Jun 5, 2026
Ethical analysis of non-oncological fertility preservation reviews challenges in reproductive autonomy and social justice
OB/GYN & Women's Health Sys. Review
Ethical analysis of non-oncological fertility preservation reviews challenges in reproductive autonomy and social justice Fertility preservation ethics face real risks for women and transgender people
This narrative review analyzes 56 scientific articles regarding non-oncological fertility preservation. The authors synthesize ethical chall…
Fertility preservation for non-cancer patients faces ethical challenges like decisional pressure and unequal access that need attention now.
Frontiers May 25, 2026
Narrative review on endometriosis and adenomyosis effects on assisted reproductive technology outcomes
OB/GYN & Women's Health Meta-analysis
Narrative review on endometriosis and adenomyosis effects on assisted reproductive technology outcomes First new insights into frozen embryo transfer for endometriosis and adenomyosis
This narrative review synthesizes evidence from 91 studies on endometriosis, deep infiltrating endometriosis, and adenomyosis in women under…
A review of 91 studies suggests frozen embryo transfer may help women with endometriosis, while adenomyosis outcomes remain mixed.
Frontiers May 18, 2026
Narrative review refutes causal link between endometriosis and migraine
Neurology Sys. Review
Narrative review refutes causal link between endometriosis and migraine Endometriosis and Migraine Share Hidden Genetic Roots
This narrative review examines the association between endometriosis and migraine. The authors refute a causal relationship and discuss shar…
New genetic research suggests endometriosis and migraine are parallel conditions driven by shared inflammatory pathways, not just hormones.
Frontiers May 15, 2026
Network meta-analysis of 107 RCTs on blood-invigorating Chinese herbal medicines for endometriosis
Hematology Meta-analysis
Network meta-analysis of 107 RCTs on blood-invigorating Chinese herbal medicines for endometriosis Chinese herbal medicines plus standard care help treat endometriosis better than standard care alone
This network meta-analysis synthesizes data from 107 RCTs evaluating blood-invigorating and stasis-resolving Chinese herbal medicines plus c…
A review of many studies shows adding specific Chinese herbs to standard treatment helps more women with endometriosis. Patients felt less p…
Frontiers May 14, 2026
Meta-analysis shows BPA exposure linked to higher endometriosis risk in 2,488 participants
OB/GYN & Women's Health Meta-analysis
Meta-analysis shows BPA exposure linked to higher endometriosis risk in 2,488 participants BPA Exposure Raises Endometriosis Risk More Than We Thought
This meta-analysis reviews data from 2,488 participants regarding bisphenol A (BPA) exposure and endometriosis risk. The authors found a sta…
• BPA exposure increases endometriosis risk by 36 percent • Helps women with unexplained pelvic pain find answers • Avoiding BPA requires ma…
Frontiers May 5, 2026
Narrative review links lactylation modification to gynecological disease pathogenesis and potential therapy
OB/GYN & Women's Health Meta-analysis
Narrative review links lactylation modification to gynecological disease pathogenesis and potential therapy New metabolic switch could help treat difficult gynecological conditions
This narrative review addresses the lack of systematic analysis on lactylation modification in gynecological diseases. The authors synthesiz…
A new cellular switch that uses energy to control genes might one day help doctors treat difficult gynecological conditions like endometrios…
Frontiers May 4, 2026
Systematic review of induction methods for pelvic inflammatory disease animal models
OB/GYN & Women's Health Sys. Review
Systematic review of induction methods for pelvic inflammatory disease animal models New animal models reveal hidden causes of pelvic pain
This systematic review evaluates various methods used to construct animal models for pelvic inflammatory disease. The authors categorize ind…
Chronic pelvic pain affects millions of women, and new research reveals how animal models are uncovering hidden triggers of pelvic inflammat…
Frontiers May 2, 2026
GWAS meta-analysis identifies genetic risk loci for female genital tract polyps in women
Genetics & Precision Medicine Meta-analysis
GWAS meta-analysis identifies genetic risk loci for female genital tract polyps in women New DNA clues link common gynecological issues to endometriosis and cancer risks
This GWAS meta-analysis examined 48,400 cases and 477,134 controls across four biobanks to identify risk loci for female genital tract polyp…
A massive DNA study of nearly half a million women reveals genetic links between common gynecological polyps, endometriosis, fibroids, and e…
medRxiv Apr 18, 2026
Ultrasound-guided interventional therapy shows higher effectiveness and fewer adverse reactions than laparoscopic cyst resection for ovarian endometriosis cysts
Oncology Meta-analysis
Ultrasound-guided interventional therapy shows higher effectiveness and fewer adverse reactions than laparoscopic cyst resection for ovarian endometriosis cysts Ultrasound-guided therapy may work better and safer than surgery for ovarian cysts
This meta-analysis evaluated ultrasound-guided interventional therapy versus laparoscopic cyst resection in patients with ovarian endometrio…
Ultrasound-guided therapy may work better and safer than surgery for ovarian cysts, offering less pain and faster recovery for women.
Apr 16, 2026
Adenomyosis localization affects infertility and pregnancy outcomes in women with intrinsic or extrinsic disease
OB/GYN & Women's Health Meta-analysis
Adenomyosis localization affects infertility and pregnancy outcomes in women with intrinsic or extrinsic disease Does where adenomyosis grows in your uterus change your chances of getting pregnant?
This narrative systematic review analyzed nine observational studies involving women with intrinsic or extrinsic adenomyosis.
Adenomyosis location matters: outer growth links to infertility while inner growth connects to pregnancy loss, showing the disease pattern c…
Frontiers Apr 9, 2026
VATS and hormonal therapy for diaphragmatic endometriosis in a 42-year-old woman with hepatic herniation
Rheumatology Sys. Review
VATS and hormonal therapy for diaphragmatic endometriosis in a 42-year-old woman with hepatic herniation Can surgery alone fix rare chest pain caused by endometriosis, or is a team approach needed?
This case report and literature review describes a 42-year-old woman with diaphragmatic endometriosis, hepatic herniation, and catamenial pn…
A 42-year-old woman's rare chest pain from endometriosis required both surgery and hormones, proving that surgical repair alone may not be e…
Frontiers Apr 9, 2026

Questions about Endometriosis

Does exposure to BPA increase my risk of developing endometriosis based on recent studies?

Yes, recent meta-analyses show BPA exposure is linked to a higher risk of endometriosis, with odds ratios of 1.36 and 1.82.

Full answer →

All Endometriosis Articles