Network meta-analysis of pharmacotherapies shows GLP-1 RAs and SGLT2is reduce composite cardiovascular death and hospitalization in HFpEF
New drugs may lower heart failure risk and improve walking distance for patients with preserved ejection fraction
This network meta-analysis evaluated 48,235 patients with heart failure with preserved ejection fraction (HFpEF) treated with various pharma…
New heart drugs lower death risk and hospital visits for patients with preserved ejection fraction while improving walking distance.
Lipidomics analysis identifies three molecular phenogroups in HFpEF, including high-risk group
Could a simple blood test reveal which heart failure patients face the highest risk?
An observational cohort study of 177 HFpEF patients and non-HF subjects in Belgian and Canadian cohorts used plasma lipidomics to identify t…
Blood fat patterns group heart failure patients into distinct types, revealing one high-risk group with severe scarring and lower survival c…
Higher prognostic nutritional index associated with lower MACE and mortality in AF and HFpEF patients
Study links better nutritional scores to lower heart risks in patients with two heart conditions
A retrospective cohort study of 734 patients with atrial fibrillation and HFpEF found that higher prognostic nutritional index (PNI) was ind…
Patients with better nutrition scores face a 63% lower risk of heart events and an 83% lower risk of death compared to those with poorer sco…
Research across Heart Failure
Related studies from across the Heart Failure family.
Intradialytic exercise improves cardiovascular function and arterial stiffness in patients on maintenance haemodialysis
Intradialytic Exercise May Improve Heart Function in Dialysis Patients
This meta-analysis of 934 patients receiving maintenance haemodialysis found that intradialytic exercise improved left ventricular ejection …
Exercise during dialysis may improve heart function and blood pressure for patients with heart failure on maintenance hemodialysis.
Four mailer types aim to increase health care proxy documentation in patients with chronic conditions
New trial plans to use mailers to help patients name proxies
This study protocol describes a factorial randomized trial of approximately 20,000 patients with cancer, congestive heart failure, or chroni…
A new study plans to see if different types of mailers can help patients with serious illnesses name a healthcare proxy.
Rheumatic heart disease prevalence in Nepal is 3.1% with significant geographic and temporal disparities
Rheumatic heart disease is much more common in rural Nepal
This meta-analysis of 209,815 participants in Nepal indicates a pooled rheumatic heart disease prevalence of 3.1%. Findings show a higher pr…
New data shows rheumatic heart disease is six times more common in rural areas of Nepal compared to the capital city of Kathmandu.
High-flow nasal cannula shows no significant difference from noninvasive ventilation in acute heart failure
High-flow nasal cannula shows no advantage over noninvasive ventilation
This meta-analysis of 1,282 patients with respiratory failure secondary to acute heart failure found no statistically significant difference…
New data shows that high-flow nasal cannula does not outperform noninvasive ventilation for patients with heart failure and respiratory issu…
Geographic and socioeconomic disparities limit access to mechanical circulatory support and heart transplantation
Heart Devices and Transplants Are Out of Reach for Many
This narrative review with scoping methods examines the global landscape of mechanical circulatory support (MCS) and heart transplantation f…
A new review finds heart transplants and mechanical support are concentrated in wealthy regions, leaving many patients without access.
Breviscapine Add-On May Improve Angina Response in Coronary Heart Disease
Breviscapine May Help Heart Disease Patients With Angina Symptoms
A meta-analysis finds breviscapine plus conventional therapy improves total effective rate in coronary heart disease with angina. Safety dat…
A new analysis finds breviscapine may improve treatment success for people with heart disease and angina. More research is needed to confirm…
Conduction system pacing reduces heart failure hospitalization and cardiomyopathy risk compared to right ventricular pacing
Conduction system pacing may lower heart failure hospital risks
This meta-analysis of randomized controlled trials involving 1466 patients with preserved or mildly reduced LVEF found that conduction syste…
A new type of heart pacing could significantly lower the risk of heart muscle damage and hospital stays for patients with heart failure.
Culturally tailored meal programs reduce hospitalization rates among patients with heart failure
Tailored Navajo meal program reduces heart failure hospital visits
Researchers evaluated a culturally and medically tailored meal program for adults with heart failure in a rural setting. The intervention wa…
A culturally tailored meal program using traditional Navajo foods helped reduce hospital visits for patients living with heart failure.
Disulfidptosis may drive cardiomyocyte injury and cytoskeletal collapse under conditions of disulfide stress
New research explores a specific cell death path in heart failure
This narrative review explores the role of disulfidptosis in heart failure and cardiomyocyte injury. The authors suggest that disulfide stre…
Scientists are looking into a process called disulfidptosis to understand how heart cells die during heart failure.
Sarcopenia and Low Grip Strength Correlate with Increased Cardiovascular Risk in Older Adults
Low Muscle Mass and Grip Strength Linked to Heart Risks
A large-scale meta-analysis identifies sarcopenia and low grip strength as significant markers for increased cardiovascular events in elderl…
Lower muscle mass and weaker grip strength are linked to a higher risk of heart disease and stroke in older adults.
Tai Chi provides positive effects for balance, mood, and cognitive performance in older adults
Tai Chi Shows Positive Effects for Older Adults with Parkinson's
This evidence map synthesized 118 systematic reviews regarding Tai Chi for older adults. The findings indicate positive effects for balance,…
Tai Chi may help older adults improve balance, reduce anxiety, and manage symptoms of Parkinson's disease and other age-related conditions.
Semaglutide reduces NT-proBNP levels and heart-failure hospitalization in adults with HFpEF and obesity
Semaglutide shows promise for heart failure and obesity patients
This meta-analysis of 6 randomized trials involving 4216 adults with HFpEF and obesity found that semaglutide significantly reduced NT-proBN…
A new look at clinical data shows semaglutide may improve symptoms and lower hospital risks for people with obesity and heart failure.
Questions about Heart Failure with Preserved Ejection Fraction
Do GLP-1 drugs and SGLT2 inhibitors reduce hospital visits for my heart failure?
Yes, both GLP-1 receptor agonists and SGLT2 inhibitors reduce hospital visits for heart failure with preserved ejection fraction (HFpEF), according to a large network meta-analysis and other studies.
Full answer →Does spironolactone lower my risk of heart problems if I have a large heart?
Yes, spironolactone may lower your risk of heart problems if you have a large heart, especially reducing heart failure hospitalizations and cardiovascular death.
Full answer →