Rule-based Clinical Decision Support System Matches Expert Assessments in Heart Failure With Preserved Ejection Fraction
AI Helps Doctors Spot Heart Failure Faster
This prospective cohort study evaluated 134 patients with exertional dyspnea and preserved left ventricular ejection fraction.
A new AI tool helps doctors diagnose stiff heart failure faster by automating complex measurements during exercise tests with high accuracy.
Combined NT-proBNP, DLK-1, PSP-D, and PCSK-9 detection shows moderate diagnostic performance for HFpEF
New blood markers may help diagnose heart failure with preserved ejection fraction more accurately
This prospective biomarker cohort study evaluated 58 HFpEF patients and 30 healthy controls to assess the diagnostic utility of specific bio…
Mixing four blood markers improves heart failure diagnosis accuracy compared to standard tests alone, offering a clearer path to early detec…
Spironolactone reduces cardiovascular events in HFpEF patients with increased LV mass or left atrial volume
Spironolactone Saves Lives in Specific Heart Failure Types
This post hoc analysis of the TOPCAT randomized controlled trial evaluated spironolactone in 757 participants with heart failure with preser…
Spironolactone cuts death risk for heart failure patients with enlarged heart chambers, proving that heart size matters just as much as pump…
HFpEF probability scores rule out disease but show limitations in AF and obesity phenotypes
HFpEF probability scores work well for typical cases but struggle with atrial fibrillation and obesity
This systematic review evaluated the performance of HFpEF probability scores (HFA-PEFF and H2FPEF) in patients with heart failure with prese…
Heart failure scores work well for typical cases but lose accuracy in patients with atrial fibrillation or obesity due to altered biological…
Network meta-analysis of pharmacotherapies shows GLP-1 RAs and SGLT2is reduce composite cardiovascular death and hospitalization in HFpEF
New drugs may lower heart failure risk and improve walking distance for patients with preserved ejection fraction
This network meta-analysis evaluated 48,235 patients with heart failure with preserved ejection fraction (HFpEF) treated with various pharma…
New heart drugs lower death risk and hospital visits for patients with preserved ejection fraction while improving walking distance.
Lipidomics analysis identifies three molecular phenogroups in HFpEF, including high-risk group
Could a simple blood test reveal which heart failure patients face the highest risk?
An observational cohort study of 177 HFpEF patients and non-HF subjects in Belgian and Canadian cohorts used plasma lipidomics to identify t…
Blood fat patterns group heart failure patients into distinct types, revealing one high-risk group with severe scarring and lower survival c…
Higher prognostic nutritional index associated with lower MACE and mortality in AF and HFpEF patients
Study links better nutritional scores to lower heart risks in patients with two heart conditions
A retrospective cohort study of 734 patients with atrial fibrillation and HFpEF found that higher prognostic nutritional index (PNI) was ind…
Patients with better nutrition scores face a 63% lower risk of heart events and an 83% lower risk of death compared to those with poorer sco…
Research across Heart Failure
Related studies from across the Heart Failure family.
Moderate mitral regurgitation associated with higher risk of primary outcome in HFrEF patients
Trial shows moderate mitral regurgitation impacts heart failure outcomes
This randomized controlled trial of 8232 patients with heart failure and reduced ejection fraction (HFrEF) evaluated the impact of mitral re…
New research identifies that patients with moderate mitral regurgitation may face higher risks in heart failure treatment outcomes.
Prediction models for heart failure in type 2 diabetes show acceptable discrimination but lack prospective testing
New Prediction Models Help Identify Heart Failure Risk in Diabetes
This meta-analysis of 65 studies evaluated prediction models for incident heart failure and heart failure hospitalization in people with typ…
New prediction models show promise in identifying heart failure risks for people living with type 2 diabetes.
Heart transplantation provides feasible treatment with favorable long-term survival for end-stage Chagas heart disease
Heart transplant offers long term survival for Chagas heart disease
This meta-analysis of 305 patients evaluates outcomes in Chagas heart disease transplant recipients. The analysis indicates that heart trans…
Heart transplants provide a viable path to long term survival for patients with advanced Chagas heart disease.
Nursing-led strategies address patient, systemic, and socio-cultural barriers to cardiac rehabilitation participation
Nurses help heart failure patients overcome barriers to cardiac rehab
This systematic review of 17 studies identifies nursing-led interventions as key facilitators for overcoming barriers to cardiac rehabilitat…
Many heart failure patients struggle to join rehab due to fear or travel issues, but nurse-led support can help them stay on track.
Dapagliflozin associated with lower risk of heart failure in frail patients with aortic stenosis
Trial shows dapagliflozin may help frail patients with aortic stenosis
This post hoc analysis examined the impact of dapagliflozin on patients with severe aortic stenosis undergoing transcatheter aortic valve im…
A new analysis suggests the medication dapagliflozin may offer specific benefits for patients with aortic stenosis who are also experiencing…
Cardiac resynchronization therapy increases left ventricular ejection fraction by 9.95% in cancer-related heart failure
Heart therapy shows promise for cancer patients with heart damage
This meta-analysis of 110 patients with cancer therapy-related cardiac dysfunction found that cardiac resynchronization therapy (CRT) increa…
A new look at heart treatments shows that a specific device can improve heart function for cancer survivors with heart damage.
Individualized mechanical circulatory support is necessary as increased hemodynamic support does not uniformly improve survival
Mechanical Support for Cardiogenic Shock Does Not Uniformly Improve Survival
This mini review examines the role of short-term mechanical circulatory support (MCS) in patients with cardiogenic shock, including those wi…
Newer reviews suggest that while mechanical support helps heart function, it does not always lead to better survival rates for patients in c…
Qili Qiangxin plus conventional medicine improves surrogate markers in heart failure after myocardial infarction
Qili Qiangxin May Improve Heart Function After Heart Attack
This meta-analysis of 1391 patients found that Qili Qiangxin combined with conventional Western medicine led to greater reductions in NT-pro…
Adding Qili Qiangxin to standard medicine may improve heart function and quality of life for patients following a heart attack.
RAAS inhibitors modulate inflammatory responses and oxidative stress across multiple chronic conditions
RAAS Inhibitors May Protect Organs Beyond Lowering Blood Pressure
This systematic review synthesizes the roles of ACEI, ARB, DRI, ARNI, and MRA in modulating inflammatory responses and oxidative stress. The…
New research suggests certain blood pressure medications may protect the heart, kidneys, and lungs by reducing inflammation and oxidative st…
An RV-first framework addresses controversies in tricuspid intervention and right ventricular support for cardiogenic shock
New framework aims to improve care for heart failure patients
This narrative review explores the role of transcatheter tricuspid interventions and mechanical circulatory support for patients with advanc…
Doctors are looking for better ways to treat heart failure and cardiogenic shock using a new approach to manage the right side of the heart.
SGLT-2is and GLP-1RAs significantly reduce heart failure related composite endpoints in type 2 diabetes
SGLT2 inhibitors and GLP-1RAs both improve heart failure outcomes
This network meta-analysis of 13,886 patients with type 2 diabetes and heart failure found that both SGLT-2is and GLP-1RAs significantly red…
New data shows both SGLT2 inhibitors and GLP-1RAs effectively reduce heart failure risks for people with type 2 diabetes.
Ventricular Arterial Coupling Surrogates Predict Mortality and Adverse Events in Acute Heart Failure
Ventricular-arterial coupling measures help identify high risk in heart failure
Meta-analysis of 36,989 patients reveals that RV-PA uncoupling predicts mortality while LV-Ao uncoupling identifies risk for in-hospital car…
New data shows that specific heart measurements can help doctors identify which heart failure patients face the highest risk of death or com…
Questions about Heart Failure with Preserved Ejection Fraction
Do GLP-1 drugs and SGLT2 inhibitors reduce hospital visits for my heart failure?
Yes, both GLP-1 receptor agonists and SGLT2 inhibitors reduce hospital visits for heart failure with preserved ejection fraction (HFpEF), according to a large network meta-analysis and other studies.
Full answer →Does spironolactone lower my risk of heart problems if I have a large heart?
Yes, spironolactone may lower your risk of heart problems if you have a large heart, especially reducing heart failure hospitalizations and cardiovascular death.
Full answer →