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Home › Conditions › Intellectual Disability

Intellectual Disability

6 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Intellectual Disability

14 trials tracked for Intellectual Disability: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 42 citations.

14Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 3 1 Phase 2 1 Other / NA 12
  1. Phase 3 Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability Completed · 42 cited
  2. Phase 2 Down Syndrome Memantine Follow-up Study Completed
  3. N/A Evaluation of Project TEAM (Teens Making Environmental and Activity Modifications) Completed
  4. N/A Clinical Utility of Pediatric Whole Exome Sequencing Completed
  5. N/A North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2 Completed
  6. N/A Dialectical Behaviour Group Therapy for Adults With Intellectual Disabilities Completed
Show 8 more trials
  1. N/A Expert Guiding Technology to Help Individuals With Developmental Challenges Build Life and Vocational Skills Completed
  2. N/A Weight Management for Adolescents With IDD Completed
  3. N/A New Skills - No Scores Research Study Completed
  4. N/A Written Language Intervention for Adults With Intellectual and Developmental Disabilities Completed
  5. N/A Promotion of Physical Activity in Adolescents With Intellectual and Developmental Disabilities Completed
  6. N/A Enhancing Genomic Laboratory Reports to Enhance Communication and Empower Patients Completed
  7. N/A Best Practices to Prevent COVID-19 Illness in Staff and People With Serious Mental Illness and Developmental Disabilities in Congregate Living Settings Completed
  8. N/A Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-19 Pandemic Completed

Showing the 14 most-cited and recently-updated of 14 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Intellectual Disability: what the trials found

In a Phase 3 trial, the administration of NT 201 Placebo resulted in significant reductions in unstimulated salivary flow rate (uSFR) at week 4 (-0.07; -0.14, p=0.0012) and continued to show significant reduction at weeks 8 and 12 (-0.07; -0.16; -0.06; -0.16, p<0.0001) 3.

The same study reported a statistically significant improvement in the Global Impression of Change Scale (GICS) as assessed by parents or caregivers at week 4 (0.63; 0.91, p=0.032) 3.

Recent results — preliminary, needs further review

  • A trial involving standard messaging for enrollment into weekly testing showed no significant difference in enrollment rates between the Special School District and Kennedy Krieger Institute 1.
  • A written language intervention was evaluated in a recent study 2.

For the clinician treating this condition

  • NT 201 Placebo is associated with statistically significant reductions in unstimulated salivary flow rate (uSFR) over a 12-week period 3.
  • Parental/carer assessment of change (GICS) showed significant improvement following NT 201 Placebo at week 4 3.

AI synthesis of 3 cited trials, updated Jun 22, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Telerehabilitation improves cognitive, behavioral, and functional outcomes for children and adolescents with intellectual disability
Psychiatry Meta-analysis
Telerehabilitation improves cognitive, behavioral, and functional outcomes for children and adolescents with intellectual disability Telerehabilitation helps children with intellectual disability
This systematic review of 28 studies involving 668 participants found that telerehabilitation is associated with improvements in communicati…
A review of 28 studies finds telerehabilitation may improve language, behavior, and cognition in children with intellectual disability.
Frontiers Jun 11, 2026
Systematic review links CNTN6 gene to neurodevelopmental and mental disorders
Neurology Sys. Review
Systematic review links CNTN6 gene to neurodevelopmental and mental disorders This Brain Protein Might Explain Autism and Schizophrenia
This systematic review summarizes evidence on CNTN6 gene involvement in neurodevelopment and disease.
Scientists have identified a specific protein that helps wire the brain and may be linked to mental health conditions.
Frontiers Apr 23, 2026
Physical activity improves motor skills and body composition in children with intellectual disabilities
Pediatrics Meta-analysis
Physical activity improves motor skills and body composition in children with intellectual disabilities Movement Is Medicine for Kids With Developmental Disabilities — Here's the Proof
A meta-analysis of 5,245 children and adolescents with intellectual and developmental disabilities found that physical activity significantl…
Structured exercise significantly improves movement skills and body composition in children with intellectual and developmental disabilities…
Apr 14, 2026
Managed transition increased AMHS care receipt and appropriate transitions at 15 months in youth with IQ ≤70
Pediatrics RCT
Managed transition increased AMHS care receipt and appropriate transitions at 15 months in youth with IQ ≤70 A Better Bridge from Teen to Adult Mental Health Care Cuts Dropout in Half
This cluster randomised clinical trial secondary analysis involved 793 participants receiving CAMHS care with IQ ≤70 near their service tran…
A planned handoff between teen and adult mental health services nearly doubled the share of young people who successfully moved to adult car…
Apr 13, 2026
Oral health factors in 500 Chinese children with special needs show high caries prevalence and associations with hygiene
Palliative Care Cohort
Oral health factors in 500 Chinese children with special needs show high caries prevalence and associations with hygiene Three in Four Special Needs Kids Have Cavities by Age 17
This retrospective cross-sectional analysis evaluated oral health in 500 children with special health care needs in Nanjing, China.
A careful look at 500 children's dental records points to clear, fixable steps caregivers can start using this week.
Frontiers Apr 13, 2026
Life Story Work reveals identity construction in young people with intellectual disability
Psychiatry
Life Story Work reveals identity construction in young people with intellectual disability How do young people with intellectual disability define who they are?
A qualitative narrative study of 8 young people with intellectual disability explored identity construction using Life Story Work methodolog…
Young people with intellectual disability define themselves as sons, daughters, and friends, letting disability be just one part of their st…
Frontiers Mar 31, 2026

Questions about Intellectual Disability

Can Life Story Work help young people with Intellectual Disability build identity?

Life Story Work helps young people with intellectual disability build identity by focusing on their roles, relationships, and values rather than just their diagnosis.

Full answer →