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Home › Conditions › macular edema

Macular edema

Part of Age-Related Macular Degeneration

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for macular edema

57 trials tracked for macular edema: 29 in phase 3 or 4 and 9 with published results. The most-cited published study has 219 citations.

57Trials tracked
29Phase 3 & 4
0Recruiting
9With published results
Phase distribution
Phase 4 5 Phase 3 24 Phase 2 15 Phase 1 1 Other / NA 12
  1. Phase 3 PeriOcular and INTravitreal Corticosteroids for Uveitic Macular Edema Trial Completed · 219 cited
  2. Phase 3 A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Branch Retinal Vein Occlusion Completed · 110 cited
  3. Phase 3 A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Central Retinal or Hemiretinal Vein Occlusion Completed · 85 cited
  4. Phase 3 Ranibizumab Intravitreal Injections in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion Completed · 43 cited
  5. Phase 3 Macular Edema Ranibizumab v. Intravitreal Anti-inflammatory Therapy Trial Completed · 26 cited
  6. Phase 4 Treatment of Diabetic Macular Edema With Aflibercept in Subjects Previously Treated With Ranibizumab or Bevacizumab Completed · 21 cited
Show 44 more trials
  1. Phase 3 Efficacy and Safety of Three Different Aflibercept Regimens in Subjects With Diabetic Macular Edema (DME) Completed · 18 cited
  2. Phase 3 Efficacy and Safety of VEGF Trap Eye in Diabetic Macular Edema (DME) With Central Involvement Completed · 15 cited
  3. Phase 3 A Study in Patients With Neovascular Age Related Macular Degeneration or Macular Edema Secondary To Retinal Vein Occlusion to Evaluate Usability of the Ranibizumab (Lucentis®) Prefilled Syringe (PFS) Completed · 4 cited
  4. Phase 4 A Safety and Efficacy Study of OZURDEX® in Macular Edema Associated With Branch Retinal Vein Occlusion Completed
  5. Phase 4 Investigation of the Change of Vision-related Quality of Life in Subjects Treated With Aflibercept According to EU Label for DME. Completed
  6. Phase 4 A Study Evaluating Dosing Regimens for Treatment With Intravitreal Ranibizumab Injections in Subjects With Macular Edema Following Retinal Vein Occlusion Completed
  7. Phase 4 Safety and Efficacy Study of Ozurdex® Compared to Lucentis® in Patients With Branch Retinal Vein Occlusion Completed
  8. Phase 3 Efficacy of an Intravitreal DEX Implant in Retinal Vein Occlusion Following Treatment With Anti-VEGF Injections. Completed
  9. Phase 3 An Open-label Extended Clinical Protocol of Ranibizumab to Evaluate Safety and Efficacy in Rare VEGF Driven Ocular Diseases. Completed
  10. Phase 3 A Safety and Efficacy Study of Dexamethasone Versus Laser Photocoagulation in Participants With Diabetic Macular Edema Completed
  11. Phase 3 A Study to Evaluate an Updated Dexamethasone Intravitreal (Into the Eye) Applicator in Adult Participants With Macular Edema Due to Diseases of the Retina Completed
  12. Phase 3 A Study to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Patients With Macular Edema Due to Retinal Vein Occlusion (RVO) Completed
  13. Phase 3 Safety and Efficacy Study of Dexamethasone in the Treatment of Patients With Macular Edema Following Retinal Vein Occlusion (RVO) Completed
  14. Phase 3 Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With Branch Retinal Vein Occlusion (BRVO) Completed
  15. Phase 3 A Study of Ranibizumab Injection in Subjects With Clinically Significant Macular Edema (ME) With Center Involvement Secondary to Diabetes Mellitus (RIDE) Completed
  16. Phase 3 A Study of the Efficacy and Safety of Ranibizumab Injection in Patients With Macular Edema Secondary to Central Retinal Vein Occlusion (CRUISE) Completed
  17. Phase 3 A Phase 3 Study To Compare The Efficacy And Safety Of 0.3 MG Pegaptanib Sodium To Sham Injections In Subjects With Diabetic Macular Edema Completed
  18. Phase 3 A Study of the Safety and Efficacy of a New Treatment for Macular Edema Resulting From Retinal Vein Occlusion Completed
  19. Phase 3 A Study of the Efficacy and Safety of Ranibizumab Injection in Patients With Macular Edema Secondary to Branch Retinal Vein Occlusion (BRAVO) Completed
  20. Phase 3 Intravitreal Aflibercept Injection in Vision Impairment Due to DME Completed
  21. Phase 3 A Study of the Safety and Efficacy of a New Treatment for Macular Edema Resulting From Retinal Vein Occlusion Completed
  22. Phase 3 Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With Central Retinal Vein Occlusion (CRVO) Completed
  23. Phase 3 A Study of Ranibizumab Injection in Subjects With Clinically Significant Macular Edema (ME) With Center Involvement Secondary to Diabetes Mellitus (RISE) Completed
  24. Phase 2 Assess the Efficacy and Safety of Repeat Intravitreal Injections of Foselutoclax (UBX1325) in Patients With DME (ASPIRE) Completed
  25. Phase 2 Intravitreal Ranibizumab 0.5MG, or 1.0mg for RVO With Macular Edema Previously Receiving Bevacizumab Completed
  26. Phase 2 Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis Completed
  27. Phase 2 Safety and Effect on Central Retinal Thickness of BI 1026706 in Patients With Diabetic Macular Edema Completed
  28. Phase 2 Study Assessing AR-1105 in Subjects With Macular Edema Due to Retinal Vein Occlusion (RVO) Completed
  29. Phase 2 Ranibizumab (Lucentis) for Macular Edema Secondary to Vein Occlusions Completed
  30. Phase 2 Safety and Efficacy of AGN208397 in the Treatment of Macular Edema Associated With Retinal Vein Occlusion (RVO) Completed
  31. Phase 2 Dosing Study of Ranibizumab for Diabetic Retinal and Macular Edema Completed
  32. Phase 2 A Clinical Safety and Efficacy Comparison of NEVANAC 0.1% to Vehicle After Cataract Surgery in Diabetic Retinopathy Patients Completed
  33. Phase 2 A 3-Month Clinical Trial to Assess the Safety and Efficacy of the OZURDEX® Intraocular Implant in Patients With Diabetes Mellitus Completed
  34. Phase 2 A Study to Evaluate the Usability of the SB11 PFS in Subjects With Wet AMD or Macular Oedema Secondary to RVO Completed
  35. Phase 2 Safety and Efficacy Study of Dexamethasone Versus Ranibizumab in Patients With Diabetic Macular Edema Completed
  36. Phase 2 REtinal Vein OccLUsion Treatment With Scatter Laser Guided by UWFA in combiNAtion With Ranibizumab Study Completed
  37. Phase 2 Bevacizumab in Combination With Visudyne Photodynamic Therapy (PDT) Completed
  38. Phase 2 Suprachoroidal Injection of Triamcinolone Acetonide With IVT Aflibercept in Subjects With Macular Edema Following RVO Completed
  39. Phase 1 Efalizumab to Treat Uveitis Completed
  40. N/A Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications Completed
  41. N/A Retrospective Study in Patients Receiving Two or More OZURDEX® Injections for Retinal Vein Occlusion (RVO) Completed
  42. N/A Study of Ozurdex® Treatment Practice in Patients With Macular Oedema Due to Retinal Vein Occlusion Completed
  43. N/A Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO Completed
  44. N/A Comparison of Initial Ozurdex (Dexamethasone Implant) to Avastin (Bevacizumab) for Treatment of Macular Edema Caused by Central Retinal Vein Occlusion (CRVO) Completed

Showing the 50 most-cited and recently-updated of 57 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Macular edema: what the trials found

Several anti-VEGF agents have demonstrated efficacy in treating macular edema. Aflibercept showed significant improvements in visual acuity (BCVA) at week 52, with a mean change of 13.7 and 12.8 letters compared to -0.2 12, and consistent gains in BCVA across various study arms [1, 2, 11]. Specifically, studies using Aflibercept reported significant reductions in central retinal thickness (CRT) at week 52 11 and high percentages of patients gaining at least 10 or 15 letters in BCVA [12, 21].

Ranibizumab has also shown consistent results for macular edema. Patients treated with Ranibizumab demonstrated significant gains in BCVA (mean change of 16.18 and 8.10 over 6 months) 22, and a high percentage of patients achieved a gain of at least 15 letters 22. Additionally, Ranibizumab was associated with improved patient-reported outcomes in the NEI-VFQ-25 composite scores 9.

Faricimab demonstrated consistent results across multiple trials, showing mean BCVA improvements of approximately 16.9 to 17.5 letters at week 24 [7, 8], with over 50% of participants gaining at least 15 letters in BCVA [7, 8].

Corticosteroid treatments provided varying results for macular edema. Dexamethasone implants showed significant reductions in central subfield thickness at 12 weeks 10 and substantial reductions in CRT (mean -120.3 to -209.5) 16, though the percentage of patients achieving a gain of $\geq$15 letters was lower compared to some anti-VEGF agents [16, 19]. A dexamethasone implant also showed that approximately 55.9% to 64.5% of participants achieved a gain of 15 or more letters in BCVA 3. Periocular triamcinolone 40 mg significantly reduced macular thickness at 8 weeks 6.

For the clinician treating this condition

  • Anti-VEGF agents such as Aflibercept, Ranibizumab, and Faricimab are established treatments for macular edema, with consistent improvements in both BCVA and anatomical measures like central retinal thickness.
  • Dexamethasone implants and periocular triamcinolone provide significant reductions in macular thickness, though clinical gains in BCVA may vary compared to anti-VEGF therapies.
  • Faricimab showed consistent BCVA improvement of approximately 17 letters at week 24 across multiple study cohorts.

AI synthesis of 8 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Ranibizumab and bevacizumab show comparable short-term efficacy for macular edema in retinal vein occlusion
Oncology Meta-analysis
Ranibizumab and bevacizumab show comparable short-term efficacy for macular edema in retinal vein occlusion Eye Drug Comparison Shows Similar Vision Gains
This meta-analysis of 759 patients with RVO-ME found no significant difference between intravitreal ranibizumab and bevacizumab monotherapy …
Two common eye injections work equally well for swelling caused by retinal vein blockage, a new analysis finds.
Aug 1, 2026
Anti-VEGF plus corticosteroids improves BCVA and reduces edema recurrence in BRVO and CRVO
Ophthalmology Meta-analysis
Anti-VEGF plus corticosteroids improves BCVA and reduces edema recurrence in BRVO and CRVO Combination therapy improves vision for patients with retinal vein occlusion
This meta-analysis of 2040 patients found that anti-VEGF plus corticosteroid combination therapy resulted in better BCVA (MD -0.09) and redu…
Adding corticosteroids to anti-VEGF injections can improve vision and reduce the need for frequent eye injections in certain retinal conditi…
Jul 5, 2026
Retrospective study links systemic BP control to better visual outcomes with conbercept for RVO-related macular edema
Dermatology Cohort
Retrospective study links systemic BP control to better visual outcomes with conbercept for RVO-related macular edema Your Blood Pressure May Decide How Well Eye Injections Work
A retrospective cohort study of 76 hypertensive patients with macular edema secondary to retinal vein occlusion found that those with contro…
If you need eye injections for fluid swelling behind the retina, keeping your blood pressure in check could decide how much vision you get b…
Frontiers Apr 13, 2026

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Aflibercept 8 mg at extended intervals yields comparable outcomes to 2 mg regardless of severity Higher doses of aflibercept show similar results for macular degeneration
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