Avacopan Demonstrates Non-Inferiority to Prednisone Taper in Granulomatosis with Polyangiitis and Microscopic Polyangiitis
Trial shows avacopan works as well as prednisone for vasculitis
A Phase 3 trial shows avacopan maintains efficacy comparable to prednisone while significantly reducing glucocorticoid exposure for GPA and …
A new trial shows that patients with specific autoimmune conditions can achieve remission using avacopan instead of tapering off steroid med…
Immunosuppression with corticosteroids and cyclophosphamide leads to clinical improvement in AAV patients with hepatic granulomas
Treatment shows success for liver issues in specific autoimmune diseases
This systematic scoping review examines the rare manifestation of hepatic granulomatosis in patients with ANCA-associated vasculitides (AAV)…
Patients with rare liver granulomas and certain autoimmune conditions saw improvement when treated with standard immunosuppressive therapies…
Genetic burden in PI3K–AKT–mTOR pathway linked to microscopic polyangiitis susceptibility in Chinese cohort
Genetic markers linked to higher risk of microscopic polyangiitis in Chinese patients
This observational cohort study in a Chinese population examined genetic burden across the PI3K–AKT–mTOR pathway and susceptibility to micro…
A specific genetic load tied to a key cell pathway raises the risk of microscopic polyangiitis, offering new clues for prevention and care.
ANCA-associated vasculitis associated with higher mortality and cardiovascular events in retrospective cohort analysis
New data links rare blood vessel diseases to higher death and heart risks
This retrospective cohort study analyzed 20,422 patients with granulomatosis with polyangiitis and 5,907 with microscopic polyangiitis using…
People with rare blood vessel diseases face nearly three times the death risk and higher heart attack rates compared to healthy people.
Japanese AAV Cohort Shows MPA Has 67.6% Five-Year Survival; Glucocorticoid Reduction Not Linked to Better Outcomes
For Japanese patients with a rare autoimmune disease, survival remains challenging
A retrospective cohort study of 460 treatment-naïve Japanese patients with AAV found microscopic polyangiitis (MPA) had the poorest prognosi…
Japanese patients with microscopic polyangiitis face a five-year survival rate of 67.6%, as older age and kidney issues raise death risk.
Research across Vasculitis
Related studies from across the Vasculitis family.
IL-5/IL-5Rα blockade provides clinically validated benefit in EGPA but requires phenotype-specific evidence for other conditions
Targeting Eosinophils Shows Promise for Specific Autoimmune Conditions
This narrative review explores the role of eosinophils and IL-5/IL-5Rα and IL-4Rα blockade in various autoimmune diseases. The authors concl…
New research highlights how targeting specific immune cells like eosinophils can help manage certain inflammatory and autoimmune diseases.
Systematic review evaluates anti-IL-5 and anti-IL-5Rα biologics for eosinophilic respiratory and systemic diseases
New Asthma Drugs Target the Real Troublemakers Hiding in Your Lungs
This systematic review examined the use of anti-IL-5 and anti-IL-5Rα biologics in patients with severe eosinophilic asthma, chronic rhinosin…
New asthma drugs target the specific immune cells causing swelling and mucus in severe asthma, nasal polyps, and rare eosinophil diseases.
Expert review outlines diagnostic and therapeutic management strategies for eosinophilic granulomatosis with polyangiitis
Rare Lung and Blood Disease Gets a Smarter Treatment Map
This expert review addresses the management of patients with eosinophilic granulomatosis with polyangiitis (EGPA), focusing on glucocorticoi…
A new expert roadmap shifts treatment for rare EGPA disease from steroids to targeted biologic drugs for patients with stubborn asthma and o…
Questions about Microscopic Polyangiitis
How does the mortality risk for microscopic polyangiitis compare to granulomatosis with polyangiitis?
Microscopic polyangiitis (MPA) generally carries a higher mortality risk than granulomatosis with polyangiitis (GPA), with studies showing poorer survival and higher hazard ratios for death in MPA patients.
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