Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Partial-Onset Seizures

Partial-Onset Seizures

Part of Epilepsy

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Partial-Onset Seizures

13 trials tracked for Partial-Onset Seizures: 12 in phase 3 or 4 and 4 with published results. The most-cited published study has 82 citations.

13Trials tracked
12Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 1 Phase 3 11 Phase 2 1
  1. Phase 3 A Study With an Open-label Extension Phase to Evaluate the Efficacy and Safety of Perampanel (E2007) Administered as an Adjunctive Therapy in Subjects With Refractory Partial-onset Seizures Completed · 82 cited
  2. Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of Long-term Adjunctive Therapy With Lacosamide in Adults With Partial-onset Seizures Completed · 25 cited
  3. Phase 3 Study for Verification of Efficacy and Safety for Perampanel Monotherapy in Untreated Participants With Partial Onset Seizures (Including Secondarily Generalized Seizures (FREEDOM Study) Completed · 21 cited
  4. Phase 3 A Safety, Efficacy, and Tolerability Trial of Pregabalin as Add-On Treatment in Pediatric Subjects <4 Years of Age With Partial Onset Seizures. Completed · 17 cited
  5. Phase 4 Study to Evaluate the Efficacy and Safety of Perampanel as Monotherapy or First Adjunctive Therapy in Subjects With Partial Onset Seizures With or Without Secondarily Generalized Seizures or With Primary Generalized Tonic-Clonic Seizures Completed
  6. Phase 3 A Trial to Evaluate the Long Term Safety and Tolerability of Lacosamide Taken as Monotherapy in Adults With Partial-onset Seizures Completed
Show 7 more trials
  1. Phase 3 Efficacy, Safety and Tolerability of TRI476 (Oxcarbazepine) in Children With Inadequately Controlled Partial Onset Seizures Completed
  2. Phase 3 Safety of Intravenous Lacosamide Dose Followed by Twice Daily Oral Lacosamide in Subjects With Partial-onset Seizures Completed
  3. Phase 3 Study to Assess the Long-term Safety of Oral Lacosamide in Subjects With Partial-onset Seizures Completed
  4. Phase 3 A Trial to Evaluate the Efficacy and Safety of Adjunctive Therapy With Lacosamide in Adults With Partial-Onset Seizures Completed
  5. Phase 3 An Open Label Study of Levetiracetam Monotherapy in Patients With Newly Diagnosed Focal Epilepsy Completed
  6. Phase 3 Open-label Study to Evaluate the Safety and Tolerability of iv Lacosamide in Japanese Adults With Partial-onset Seizures Completed
  7. Phase 2 An Open Label Study of L059 Intravenous (IV) in Japanese Epilepsy Subjects With Partial Onset Seizures Completed

Showing the 13 most-cited and recently-updated of 13 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
FDA Approves Lamotrigine Tablets (lamotrigine) for Epilepsy and Bipolar Disorder Maintenance
Neurology FDA Approval
FDA Approves Lamotrigine Tablets (lamotrigine) for Epilepsy and Bipolar Disorder Maintenance The FDA has approved a drug called lamotrigine for epilepsy and bipolar disorder treatment
Lamotrigine tablets were approved as adjunctive therapy for partial-onset seizures, PGTC seizures, and Lennox-Gastaut syndrome in patients a…
The FDA has approved lamotrigine to help control seizures in children as young as two and maintain mood stability for adults with bipolar di…
FDA Apr 14, 2026
FDA Approves Levetiracetam for Partial-Onset, Myoclonic, and Primary Generalized Tonic-Clonic Seizures
Neurology FDA Approval
FDA Approves Levetiracetam for Partial-Onset, Myoclonic, and Primary Generalized Tonic-Clonic Seizures FDA approves a seizure medicine called levetiracetam for children and adults
Levetiracetam is approved for the treatment of partial-onset seizures in patients 1 month and older, and as adjunctive therapy for myoclonic…
The FDA now approves levetiracetam for children as young as one month and adults to treat specific seizure types.
FDA Apr 10, 2026
FDA Approves Gabapentin Capsules (gabapentin) for Postherpetic Neuralgia and Partial Onset Seizures
Neurology FDA Approval
FDA Approves Gabapentin Capsules (gabapentin) for Postherpetic Neuralgia and Partial Onset Seizures FDA approves a new generic version of the drug gabapentin for nerve pain and seizures
The FDA has approved Gabapentin Capsules, USP for the management of postherpetic neuralgia in adults and as adjunctive therapy for partial o…
FDA approves a new generic gabapentin capsule for nerve pain and seizures, offering patients another low-cost treatment option alongside exi…
FDA Apr 9, 2026

Research across Epilepsy

Related studies from across the Epilepsy family.

Higher levels of dissociative symptoms observed in individuals with functional neurological disorder
Psychiatry Case-Control
Higher levels of dissociative symptoms observed in individuals with functional neurological disorder People with FND experience higher levels of dissociation
This pilot study used ecological momentary assessment to compare symptoms between individuals with functional neurological disorder and heal…
New tracking data shows that individuals living with functional neurological disorder report significantly more dissociative symptoms during…
Frontiers Apr 30, 2026
Diagnostic accuracy study of EEG network measures for epilepsy versus functional seizures
Neurology
Diagnostic accuracy study of EEG network measures for epilepsy versus functional seizures EEG Network Measures May Help Distinguish Epilepsy From Functional Seizures
This diagnostic accuracy study evaluated multivariate resting-state EEG network measures in 148 individuals with suspected seizure disorders…
EEG network measures can distinguish epilepsy from functional seizures with 67.5% accuracy, offering a new tool to help doctors diagnose sei…
medRxiv Apr 19, 2026
Case series and literature review expands phenotypic spectrum of germline PIGA variants
Genetics & Precision Medicine Sys. Review
Case series and literature review expands phenotypic spectrum of germline PIGA variants Do fever spikes make seizures worse in children with specific genetic epilepsy?
This case series and literature review describes five germline PIGA missense pathogenic/likely pathogenic variants across six unrelated fami…
Every child with this rare epilepsy gene change reacts to fever, while specific genetic spots determine if symptoms are severe or mild.
Frontiers Apr 16, 2026
Genetic mutations in febrile sensitivity epilepsy correlate with earlier onset and specific diagnoses in children
Neurology Cohort
Genetic mutations in febrile sensitivity epilepsy correlate with earlier onset and specific diagnoses in children Fever-Triggered Seizures in Children Trace Back to Specific Genes
This retrospective cohort study examined 30 gene-positive cases and 31 gene-negative controls at Wuxi Children's Hospital.
Half of children with fever-triggered seizures carry specific gene mutations that help doctors predict which treatments will work and which …
Frontiers Apr 14, 2026

Questions about Partial-Onset Seizures

Can lamotrigine be used for partial-onset seizures in patients with bipolar disorder?

Yes, lamotrigine is FDA-approved to treat partial-onset seizures in patients with bipolar disorder, serving both seizure control and mood stabilization.

Full answer →