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Home › Conditions › Polycystic Ovary Syndrome

Polycystic Ovary Syndrome

Part of Ovarian Cysts

24 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Polycystic Ovary Syndrome

64 trials tracked for Polycystic Ovary Syndrome: 27 in phase 3 or 4 and 13 with published results. The most-cited published study has 6045 citations.

64Trials tracked
27Phase 3 & 4
0Recruiting
13With published results
Phase distribution
Phase 4 10 Phase 3 17 Phase 2 11 Phase 1 4 Other / NA 22
  1. Phase 4 The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS Completed · 6,045 cited
  2. Phase 4 LIPT - Liraglutide in Polycystic Ovary Syndrome Completed · 165 cited
  3. Phase 3 Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS Completed · 154 cited
  4. Phase 4 The Effects of Vitamin D on Angiogenic Factors in Women With Polycystic Ovary Syndrome Completed · 114 cited
  5. Phase 4 Combined Letrozole and Clomid in Women With Infertility and PCOS Completed · 96 cited
  6. Phase 3 EQW, DAPA, EQW/DAPA, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS) Completed · 92 cited
Show 44 more trials
  1. Phase 3 Liver and Fat Regulation in Overweight Adolescent Girls Completed · 85 cited
  2. Phase 4 Insulin Resistance, Polycystic Ovary Syndrome, and Bone Research Study Completed · 44 cited
  3. Phase 4 The Effect of Dipeptidyl Peptidase 4 Inhibition on Growth Hormone Secretion in Women With Polycystic Ovarian Syndrome Completed · 39 cited
  4. Phase 3 Saxagliptin + Metformin Compared to Saxagliptin or Metformin Monotherapy in PCOS Women With Impaired Glucose Homeostasis Completed · 30 cited
  5. Phase 3 Induction of Ovulation With Raloxifene or Clomiphene Citrate in Polycystic Ovarian Syndrome Completed · 17 cited
  6. Phase 3 Comparing the Effects of Oral Contraceptive Pills Versus Metformin Completed · 2 cited
  7. Phase 3 Treating PCOS With Semaglutide vs Active Lifestyle Intervention Completed
  8. Phase 4 Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism Completed
  9. Phase 4 Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS Completed
  10. Phase 4 Continuous Versus Cyclical OCP Use in PCOS Completed
  11. Phase 4 Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS) Completed
  12. Phase 3 Cinnamon Extract on Menstrual Cycles in PolyCystic Ovary Syndrome (PCOS) Completed
  13. Phase 3 Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS) Completed
  14. Phase 3 Metabolic and Neuro-Endocrine Effect of Treating PCOS in Adolescents Completed
  15. Phase 3 The Effect of Vitamin D Supplementation Among Overweight Jordanian Women With Polycystic Ovary Syndrome (PCOS) Completed
  16. Phase 3 Pregnancy in Polycystic Ovary Syndrome II Completed
  17. Phase 3 Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy Completed
  18. Phase 3 Theca Cell Function in Women With Polycystic Ovary Syndrome (PCOS) Completed
  19. Phase 3 Trial to Assess the Clinical Efficacy and Safety of MSJ-0011 in Inducing Ovulation in Anovulatory or Oligo-ovulatory Japanese Women Completed
  20. Phase 3 Analysis of Two Therapeutic With Cetrotide® in Polycystic Ovarian (PCO) Women in Assisted Reproductive Technology (ART) Completed
  21. Phase 3 Treatment of Adolescent Polycystic Ovary Syndrome (PCOS) Completed
  22. Phase 2 Study of Pharmacodynamics of LIK066 in Overweight and Obese Women With Polycystic Ovary Syndrome Completed
  23. Phase 2 Study of the Safety and Efficacy of Elagolix in Women With Polycystic Ovary Syndrome Completed
  24. Phase 2 Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS) Completed
  25. Phase 2 The University of Michigan PCOS Intervention Using Nutritional Ketosis Completed
  26. Phase 2 Treatment of Hyperandrogenism Versus Insulin Resistance in Infertile Polycystic Ovary Syndrome (PCOS) Women Completed
  27. Phase 2 Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction Completed
  28. Phase 2 Cavitation Ultrasound in Treatment of Patients With PCOS Completed
  29. Phase 2 Vitamin D for the Treatment of Women With Polycystic Ovary Syndrome (PCOS) Completed
  30. Phase 2 A Trial of Lipitor (Atorvastatin) for the Treatment of Polycystic Ovary Syndrome (PCOS) in Women With Elevated Low-density Lipoprotein (LDL) Cholesterol Completed
  31. Phase 2 The Efficacy and Safety Study of Tung's Acupuncture for Polycystic Ovarian Syndrome Completed
  32. Phase 2 Androgen Excess as a Cause for Adipogenic Dysfunction in PCOS Women Completed
  33. Phase 1 Ovulation Induction in Women With Clomiphene Citrate Resistant PCOS Completed
  34. Phase 1 Treatment With Metformin and Combination of Metformin and Pioglitazone in Polycystic Ovarian Syndrome Completed
  35. Phase 1 Effect of Metformin on Early Pregnancy Loss in Pregnant Women With Polycystic Ovarian Syndrome Completed
  36. Phase 1 Determining How Quickly Progesterone Slows LH Pulse Frequency Completed
  37. N/A Oral Amino Acid Nutrition to Improve Glucose Excursions in PCOS Completed
  38. N/A Behavioral Economics for Activity Motivation in Adolescents (BEAM) Completed
  39. N/A Ovarian Morphology and Theca Cell Androgen Production in Women With Polycystic Ovary Syndrome (PCOS) Completed
  40. N/A Sex Steroids, Sleep, and Metabolic Dysfunction in Women Completed
  41. N/A Effect of Increased Circulating Androgens on Granulosa Cell Responses to FSH. Completed
  42. N/A Evaluation of Vitamin D in Women With PCOS and Sexual Dysfunction Completed
  43. N/A Metabolic Study of Women With Polycystic Ovary Syndrome and Sleep Apnea Completed
  44. N/A Nimodipine to Prevent LH Surge During Ovulation Induction: Blinded Placebo-controlled RCT Completed

Showing the 50 most-cited and recently-updated of 64 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Meta-analysis shows LAP levels elevated in PCOS patients with Metabolic Syndrome
Diabetes & Endocrinology Meta-analysis
Meta-analysis shows LAP levels elevated in PCOS patients with Metabolic Syndrome LAP levels may help screen for metabolic syndrome in PCOS patients
This meta-analysis evaluates the accuracy of the lipid accumulation product (LAP) for screening metabolic syndrome in patients with polycyst…
In PCOS patients, higher LAP levels are linked to metabolic syndrome, a condition that raises heart disease and diabetes risk.
Frontiers Apr 16, 2026
Bioinformatics study identifies shared immune genes and potential drugs for PCOS and T2DM
Diabetes & Endocrinology Cohort
Bioinformatics study identifies shared immune genes and potential drugs for PCOS and T2DM Could existing drugs treat shared genes in PCOS and type 2 diabetes?
A preclinical bioinformatics and experimental validation study analyzed GEO datasets from patients with PCOS and T2DM, identifying 239 commo…
A study identified 239 genes linked to both PCOS and type 2 diabetes, with 40 existing drugs like maraviroc potentially targeting them for n…
Frontiers Apr 16, 2026
Gut microbiome dysbiosis and dietary modifications are associated with Polycystic Ovary Syndrome in women of reproductive age
OB/GYN & Women's Health Sys. Review
Gut microbiome dysbiosis and dietary modifications are associated with Polycystic Ovary Syndrome in women of reproductive age Your Gut Microbiome May Be Playing a Hidden Role in PCOS
This systematic review examined the role of gut microbiome dysbiosis, dietary modifications, and probiotic supplementation in women of repro…
A comprehensive review finds that disruptions in gut bacteria may fuel the hormonal chaos, insulin resistance, and inflammation at the heart…
Frontiers Apr 14, 2026
Scoping review of molecular pathways in insulin resistance among women with PCOS
Diabetes & Endocrinology Sys. Review
Scoping review of molecular pathways in insulin resistance among women with PCOS Your PCOS Symptoms May Start in Your Cells, Not Your Weight
This scoping review examined molecular or cellular pathways related to insulin resistance or glucose metabolism in women of reproductive age…
Women with PCOS often face insulin resistance rooted in cells, not weight, shifting treatment focus from body size to cellular signals for b…
Frontiers Apr 13, 2026
Review of quercetin in metabolic diseases shows promise but lacks clinical validation
Diabetes & Endocrinology RCT
Review of quercetin in metabolic diseases shows promise but lacks clinical validation Review suggests quercetin may have multiple beneficial effects on metabolic conditions
This review evaluates quercetin for conditions including diabetes, obesity, and gout.
A natural compound found in fruits and vegetables shows promise for managing type 2 diabetes, obesity, and fatty liver disease, though human…
Frontiers Apr 13, 2026
Systematic review shows PCOS in obese women links to high MASLD and 2–4 fold increased cardiovascular and diabetes risks
Diabetes & Endocrinology Sys. Review
Systematic review shows PCOS in obese women links to high MASLD and 2–4 fold increased cardiovascular and diabetes risks PCOS Is Not Just About Your Ovaries Anymore
This systematic review evaluated the extra-ovarian health impacts of polycystic ovary syndrome (PCOS) in women, with a focus on those with o…
Polycystic ovary syndrome is being rethought as a full-body metabolic condition, and that shift could change how — and by whom — it's treate…
Frontiers Apr 13, 2026
Chinese women with PCOS phenotypes A, B, C show higher BMI, WC, and blood pressure than phenotype D
Diabetes & Endocrinology Cohort
Chinese women with PCOS phenotypes A, B, C show higher BMI, WC, and blood pressure than phenotype D Not All PCOS Is The Same — And Your Heart May Know It
A cross-sectional study of 206 Chinese women with PCOS found that phenotypes A, B, and C had significantly higher BMI, waist circumference, …
The form of PCOS you have — A, B, C, or D — may shape your future heart risk far more than the label alone suggests.
Frontiers Apr 13, 2026
Meta-analysis finds liraglutide improves menstrual frequency and BMI in overweight women with PCOS
OB/GYN & Women's Health Meta-analysis
Meta-analysis finds liraglutide improves menstrual frequency and BMI in overweight women with PCOS A Common Weight Loss Drug May Ease a Hidden Cause of Infertility
A systematic review and meta-analysis of 330 overweight or obese women with PCOS found liraglutide significantly increased menstrual frequen…
A common weight loss drug helps overweight women with PCOS restore regular periods and improve metabolic health.
Apr 12, 2026
Homocysteine and androgen profiles show outcome-specific associations in PCOS patients with infertility, live birth, or spontaneous abortion
Diabetes & Endocrinology Cohort
Homocysteine and androgen profiles show outcome-specific associations in PCOS patients with infertility, live birth, or spontaneous abortion Homocysteine Levels Shift Meaningfully During Pregnancy
This retrospective cohort study evaluated homocysteine and androgen profiles in 875 PCOS patients categorized by reproductive outcomes.
In women with PCOS, high homocysteine links strongly to male hormones when conception fails, but this connection weakens significantly durin…
Frontiers Apr 10, 2026
Feasibility study finds time-restricted eating safe in PCOS with exploratory metabolic signals
OB/GYN & Women's Health RCT
Feasibility study finds time-restricted eating safe in PCOS with exploratory metabolic signals Can time-restricted eating help people with PCOS lose weight safely?
A 24-week crossover feasibility RCT in 11 participants with PCOS found time-restricted eating (18-hour fast) was safe with near-total compli…
A small study found that time-restricted eating was safe and helped people with PCOS lose weight and improve blood sugar levels, though rese…
Apr 9, 2026
Review Proposes Gut Microbiota-Ferroptosis Axis in PCOS and Potential TCM Role
OB/GYN & Women's Health Sys. Review
Review Proposes Gut Microbiota-Ferroptosis Axis in PCOS and Potential TCM Role Review explores gut bacteria link to PCOS and potential role of Chinese herbal medicine
A systematic review proposes a theoretical perspective that gut microbiota dysbiosis may trigger ferroptosis in ovarian granulosa cells in P…
A scientific review explored how gut bacteria imbalances might contribute to PCOS by triggering a specific type of cell stress called ferrop…
Frontiers Apr 3, 2026
Narrative review explores hepatokines and hepato-ovarian axis in PCOS metabolic disorders
Diabetes & Endocrinology Sys. Review
Narrative review explores hepatokines and hepato-ovarian axis in PCOS metabolic disorders Could your liver be talking to your ovaries? A new PCOS theory emerges
A narrative review summarizes existing evidence on the association between PCOS, glycolipid metabolic disorders, and hepatokines in women of…
A new theory suggests the liver and ovaries constantly signal each other, creating a cycle that links PCOS with fatty liver and blood sugar …
Frontiers Apr 2, 2026

Questions about Polycystic Ovary Syndrome

Does being obese make Autoimmune Thyroiditis more common in women with PCOS?

Yes, obesity is linked to a higher prevalence of autoimmune thyroiditis in women with PCOS, with one study showing 23.6% in obese vs. 18.6% in non-obese.

Full answer →
How does exposure to endocrine disrupting chemicals affect metabolic markers in Polycystic Ovary Syndrome?

Higher exposure to endocrine disrupting chemicals (EDCs) like BPA and phthalates is linked to worse metabolic markers in PCOS, including higher fasting insulin and insulin resistance.

Full answer →
What common genes link Polycystic Ovary Syndrome and type 2 diabetes according to recent studies?

Recent studies link PCOS and type 2 diabetes through shared genetic variants, notably the insulin gene VNTR and epigenetic changes in metabolism-related genes.

Full answer →
Are women with Polycystic Ovary Syndrome more likely to have autoimmune thyroiditis if they are obese?

Yes, a retrospective study found that obese women with PCOS have a higher prevalence of autoimmune thyroiditis (23.6%) compared to non-obese women with PCOS (18.6%).

Full answer →