Plasma cytokines and CSF ROS measured in MS phenotypes show associations with disability and cognition.
New Clues Explain Why Some MS Patients Lose Mobility Without Inflammation
This multicenter cohort study measured plasma cytokines and CSF ROS in participants with MS and other neurological disorders. IL-8 and CSF R…
A new study reveals that in a form of progressive MS without active inflammation, brain stress signals—not inflammation—predict disability a…
MRI outcomes show weak association with disability in primary progressive multiple sclerosis patients
MRI results show weak connection to disability changes in progressive multiple sclerosis
This Phase 3 trial secondary analysis evaluated 943 patients with primary progressive multiple sclerosis treated with glatiramer acetate ove…
MRI scans show weak links to disability changes in progressive multiple sclerosis, challenging their use as reliable trial endpoints for thi…
High-dose melatonin linked to hepatotoxicity in small PP-MS trial, prompting early halt
High-dose melatonin trial halted after liver safety concerns in MS patients
A phase I/II RCT of 8 patients with PP-MS on stable ocrelizumab found that adjunctive high-dose oral melatonin (300 mg/day) was associated w…
A high-dose melatonin trial for multiple sclerosis stopped early after three of four patients developed mild liver injury, though the issue …