MiniDock MTB Test Shows High Sensitivity and Specificity for Tuberculosis Detection
A new test finds TB in people who cough up nothing
This prospective cross-sectional study evaluated the MiniDock MTB test using sputum and tongue swabs in 1380 patients with presumptive pulmo…
A new test found tuberculosis in over 85% of patients who could not produce a cough sample, offering a faster way to diagnose the disease in…
Systematic review and meta-analysis shows reduced lung function in children with post-tuberculosis treatment compared to healthy controls
Children treated for TB may face lasting lung damage
This systematic review and meta-analysis evaluated pooled mean z-scores for FEV1, FVC, and FEV1/FVC ratio in children (≤18 years) with pulmo…
Kids treated for TB can have lasting lung problems, even after recovery, a new analysis finds.
Retrospective Study Shows 3D ResNeXt Classifier Distinguishes NTM-LD from PTB in 409 Patients
New AI Tool Helps Doctors Tell Two Lung Infections Apart
This retrospective cohort study evaluated a 3D ResNeXt-based deep learning classifier in 409 patients with microbiologically confirmed diagn…
A new computer program can help doctors tell two similar lung diseases apart using CT scans.
Phase 1 trial shows ESAT6-MPT64 skin test safe with high sensitivity for active TB
New TB Skin Test Shows Promise in Early Human Trial
A Phase 1 randomized clinical trial in 60 participants (30 healthy controls, 30 active TB patients) found the recombinant ESAT6-MPT64 skin t…
A new skin test for tuberculosis proved safe and accurately identified active cases in the first human trial, offering a simpler, cheaper al…
Age-period-cohort analysis shows declining bacteriologically confirmed pulmonary tuberculosis incidence in Hunan Province, China, 2009–2023
For decades, the fight against tuberculosis (TB) has followed a familiar script. But new data reveals the story is changing. The faces of those most vulnerable are shifting in surprising ways
This review analyzed population-based surveillance data from Hunan Province, China, from 2009 to 2023 to assess trends in bacteriologically …
Tuberculosis risk now peaks in young adults and the elderly, with the sharpest rise in the oldest age group, signaling a shift in who needs …
Combined radiomics-clinical model improves AP for differentiating pulmonary tuberculosis from non-tuberculous lung lesions on CT
New CT model may help distinguish tuberculosis from other lung lesions in some patients
This observational study evaluated 900 patients with pulmonary tuberculosis or non-tuberculous solid lung lesions.
A new computer model using CT scans and clinical data outperforms standard methods in distinguishing tuberculosis from other lung lesions in…
Clinical prediction model differentiates NTM pulmonary disease from tuberculosis in hospitalized patients
Can a simple checklist help doctors tell two serious lung infections apart?
A retrospective cross-sectional cohort study of 351 hospitalized patients with microbiologically confirmed NTM-PD or PTB developed a six-var…
A simple checklist using age, gender, and lung conditions helps doctors quickly tell apart two serious lung infections that need different t…
Pilot project describes TB contact management in Ugandan households without reported outcomes
Pilot project in Uganda manages TB risk among household contacts
A pilot project report describes case finding and comprehensive management of household contacts of people with pulmonary TB in Uganda.
A pilot project in Uganda manages tuberculosis risk for household contacts of people living with TB.
Research across Tuberculosis
Related studies from across the Tuberculosis family.
Video observed therapy improves treatment success and adherence in adults with tuberculosis
Digital Tools Show Better Success Rates for Tuberculosis Treatment
This network meta-analysis of 29 randomized controlled trials evaluated digital health interventions for tuberculosis. Video observed therap…
Video observed therapy shows higher success and adherence rates for patients with tuberculosis compared to traditional face-to-face methods.
Water buffalo act as reservoirs for infectious diseases in mixed livestock systems
Water Buffalo May Spread Diseases to Other Livestock
This systematic review analyzes 180 articles regarding infectious diseases in water buffalo. The authors conclude that these animals are inc…
A review of 180 articles suggests water buffalo act as disease reservoirs, meaning they can pass infections to other animals in mixed farmin…
HIV linked to lower odds of post-TB lung disease; undernutrition raises risk
Undernutrition and HIV may lower or raise lung damage risk after tuberculosis in low-income nations
This systematic review and meta-analysis of 41 studies in LMICs found that HIV was associated with reduced odds of spirometry-defined post-t…
New analysis of data from low-income countries shows mixed results on how HIV, diabetes, and poor nutrition affect lung health after tubercu…
Immediate antituberculosis therapy did not reduce mortality in HIV-related sepsis overall
Immediate TB treatment helps only those with confirmed infection in HIV sepsis
This trial investigated whether starting antituberculosis treatment immediately or using high doses improved survival in adults with HIV-rel…
In HIV sepsis, starting TB drugs immediately did not lower death rates overall, but helped only patients later confirmed to have TB.
Ethambutol optic neuropathy incidence 1.54 percent with renal impairment and hypertension as key risk factors
Kidney disease and high blood pressure raise risk of vision loss from TB drug
This systematic review and meta-analysis synthesized evidence on ethambutol optic neuropathy and tuberculous meningitis complications. The p…
A massive review of over 260,000 patients found that kidney problems and high blood pressure make vision loss from the TB drug ethambutol mu…
Narrative review on vitamin D and VDR in gastrointestinal and pulmonary diseases
Vitamin D's Role in Gut and Lung Health Examined
This narrative review synthesizes evidence on vitamin D deficiency and VDR expression across gastrointestinal and pulmonary conditions. The …
A review explores how vitamin D deficiency and VDR expression may influence digestive and respiratory diseases, but more research is needed.
Case report review: BPaLM for MDR-TB with cerebral or bone involvement shows mixed outcomes
New Drug Regimen Shows Promise For Rare Bone And Brain TB Cases
This review of a case report describes two patients with multidrug-resistant tuberculosis (MDR-TB) involving cerebral or bone sites treated …
A new short drug combo cleared bone and brain TB in one patient but side effects stopped treatment for another.
Systematic review and meta-analysis of MDR-TB prevalence in the MENA region
TB drug resistance in Middle East and North Africa
This meta-analysis of 25 studies from 6 countries synthesized the prevalence of multidrug-resistant tuberculosis in the MENA region. The poo…
A review of 25 studies found about 3.5% of TB patients in the region have drug-resistant strains. The findings highlight a need for stronger…
Meta-analysis of dolutegravir-based ART and risk-stratified HIV care in Uganda
HIV Treatment Works Better Now, But One Problem Remains
This meta-analysis and cohort review examined viral non-suppression rates among people with HIV in Uganda receiving dolutegravir-based ART. …
New HIV drugs are highly effective, yet thousands of patients in Uganda still have uncontrolled virus, and a fresh approach using routine da…
Expert consensus guidelines for N-acetylcysteine use in various respiratory conditions
Experts share new guidance on using N-acetylcysteine for lung health
This expert consensus guideline reviews the clinical utility of N-acetylcysteine (NAC) across several respiratory diseases. The authors sugg…
Medical experts have reached a consensus on how a specific supplement might help people managing various chronic lung diseases.
Digital chest radiography with CAD shows variable sensitivity for asymptomatic tuberculosis in South African adults
Digital scans miss many silent tuberculosis cases in South Africa adults
This cohort study evaluated digital chest radiography (dCXR) read by blinded human readers and qXR CAD in 1353 adults in South Africa.
New data from South Africa shows digital scans and computer tools miss many silent tuberculosis cases, raising questions about current scree…
Meta-analysis shows linezolid-containing regimens for multidrug/rifampicin-resistant tuberculosis
Linezolid helps treat drug resistant tuberculosis
This meta-analysis of 3019 patients evaluates the efficacy and safety of linezolid-containing regimens compared to standard of care for…
New evidence shows that adding linezolid to treatment helps patients with drug resistant tuberculosis achieve better health outcomes.
Questions about Pulmonary Tuberculosis
What factors help differentiate non-tuberculous mycobacterial disease from tuberculosis in patients?
NTM lung disease is more likely in older patients with bronchiectasis, COPD, or diabetes, and often shows thin-walled cavities on CT; TB-IGRA is usually negative in NTM.
Full answer →How well does a combined radiomics model distinguish tuberculosis from other lung lesions?
A combined radiomics model shows good accuracy (AP 0.85-0.91) for distinguishing tuberculosis from other lung lesions on CT, though performance drops in temporal validation (AP 0.62).
Full answer →Is the rate of confirmed pulmonary tuberculosis cases dropping in Hunan Province?
Data from Hunan Province shows the rate of confirmed pulmonary tuberculosis cases dropped by an average of 2.2% annually between 2009 and 2023, though the decline slowed after 2017.
Full answer →