Bronchoscopic resection and individualized therapy may treat tracheobronchial tuberculosis presenting as endobronchial masses
Rare airway tuberculosis found in young man's bronchial mass
This case report and literature review describes a 21-year-old male with tumorous tracheobronchial tuberculosis complicated by infiltrative …
A 21-year-old's airway mass turned out to be a rare form of tuberculosis. Early removal and treatment led to marked improvement.
Pulmonary TB History Linked to Higher COPD Odds
Past tuberculosis infection significantly increases risk of developing lung disease
Meta-analysis of over 1 million people finds prior pulmonary TB associated with 2.65 times higher odds of COPD.
A history of pulmonary tuberculosis is linked to a much higher risk of developing chronic obstructive pulmonary disease, especially in certa…
MiniDock MTB Test Shows High Sensitivity and Specificity for Tuberculosis Detection
A new test finds TB in people who cough up nothing
This prospective cross-sectional study evaluated the MiniDock MTB test using sputum and tongue swabs in 1380 patients with presumptive pulmo…
A new test found tuberculosis in over 85% of patients who could not produce a cough sample, offering a faster way to diagnose the disease in…
Systematic review and meta-analysis shows reduced lung function in children with post-tuberculosis treatment compared to healthy controls
Children treated for TB may face lasting lung damage
This systematic review and meta-analysis evaluated pooled mean z-scores for FEV1, FVC, and FEV1/FVC ratio in children (≤18 years) with pulmo…
Kids treated for TB can have lasting lung problems, even after recovery, a new analysis finds.
Retrospective Study Shows 3D ResNeXt Classifier Distinguishes NTM-LD from PTB in 409 Patients
New AI Tool Helps Doctors Tell Two Lung Infections Apart
This retrospective cohort study evaluated a 3D ResNeXt-based deep learning classifier in 409 patients with microbiologically confirmed diagn…
A new computer program can help doctors tell two similar lung diseases apart using CT scans.
Phase 1 trial shows ESAT6-MPT64 skin test safe with high sensitivity for active TB
New TB Skin Test Shows Promise in Early Human Trial
A Phase 1 randomized clinical trial in 60 participants (30 healthy controls, 30 active TB patients) found the recombinant ESAT6-MPT64 skin t…
A new skin test for tuberculosis proved safe and accurately identified active cases in the first human trial, offering a simpler, cheaper al…
Age-period-cohort analysis shows declining bacteriologically confirmed pulmonary tuberculosis incidence in Hunan Province, China, 2009–2023
For decades, the fight against tuberculosis (TB) has followed a familiar script. But new data reveals the story is changing. The faces of those most vulnerable are shifting in surprising ways
This review analyzed population-based surveillance data from Hunan Province, China, from 2009 to 2023 to assess trends in bacteriologically …
Tuberculosis risk now peaks in young adults and the elderly, with the sharpest rise in the oldest age group, signaling a shift in who needs …
Combined radiomics-clinical model improves AP for differentiating pulmonary tuberculosis from non-tuberculous lung lesions on CT
New CT model may help distinguish tuberculosis from other lung lesions in some patients
This observational study evaluated 900 patients with pulmonary tuberculosis or non-tuberculous solid lung lesions.
A new computer model using CT scans and clinical data outperforms standard methods in distinguishing tuberculosis from other lung lesions in…
Clinical prediction model differentiates NTM pulmonary disease from tuberculosis in hospitalized patients
Can a simple checklist help doctors tell two serious lung infections apart?
A retrospective cross-sectional cohort study of 351 hospitalized patients with microbiologically confirmed NTM-PD or PTB developed a six-var…
A simple checklist using age, gender, and lung conditions helps doctors quickly tell apart two serious lung infections that need different t…
Pilot project describes TB contact management in Ugandan households without reported outcomes
Pilot project in Uganda manages TB risk among household contacts
A pilot project report describes case finding and comprehensive management of household contacts of people with pulmonary TB in Uganda.
A pilot project in Uganda manages tuberculosis risk for household contacts of people living with TB.
Research across Tuberculosis
Related studies from across the Tuberculosis family.
Meta-analysis-guided sampling plan targets 14 zoonotic and animal diseases across India
New sampling plan helps track diseases jumping from animals to humans
This meta-analysis pools prevalence estimates for 10 zoonotic and 4 transboundary animal diseases in India, reporting a range of 4 to 30% ac…
A new plan for monitoring animal diseases in India helps track infections like Q-fever and scrub typhus before they spread to people.
Multi-scale computational methods identify pivotal tuberculosis vulnerabilities and predict drug resistance with high fidelity
Computational Methods Identify New Targets for Tuberculosis Treatment
This systematic review evaluates multi-scale computational methods including machine learning and molecular dynamics for tuberculosis drug d…
New computer modeling techniques are identifying key targets and predicting drug resistance to help speed up the development of tuberculosis…
Host-directed therapy including metformin and statins may modulate immune response in tuberculosis patients
Repurposed Drugs Like Metformin May Help Fight Tuberculosis
This narrative review explores host-directed therapy (HDT) as an adjunctive strategy to modulate immune responses and limit immunopathology …
New research explores how host-directed therapies, including common drugs like metformin and statins, could help the body fight tuberculosis…
3HP with SMS reminders increases treatment completion to 84.9% compared to 65.4% for 4RIF
SMS reminders help more people finish tuberculosis treatment
This randomized controlled trial of 210 individuals with tuberculosis infection found that 3HP with SMS reminders resulted in a higher treat…
A new trial shows that a shorter treatment plan paired with text message reminders helps more people finish their tuberculosis medication.
Tobacco smoking history increases odds of antibiotic-resistant infections including tuberculosis-related resistance
Tobacco smoking increases risk of antibiotic-resistant bacterial infections
This meta-analysis of more than 35,000 participants indicates that tobacco smoking history is associated with higher odds of antibiotic-resi…
A large review of over 35,000 people shows that a history of smoking significantly increases the risk of developing drug-resistant infection…
Pre-XDR-TB affects 3% and XDR-TB 1% of MDR-TB patients in Ethiopia
Drug-Resistant TB Strains Affect 4% of Ethiopian MDR-TB Patients
This meta-analysis estimates the prevalence of pre-extensively drug-resistant (Pre-XDR-TB) and extensively drug-resistant tuberculosis (XDR-…
About 4 in 100 MDR-TB patients in Ethiopia also carry harder-to-treat TB strains, a new analysis finds.
Gestational HIV exposure does not increase tuberculosis disease risk in children who are HIV-exposed uninfected
Comparing Tuberculosis Risk in Children Exposed to HIV During Pregnancy
This meta-analysis of 18 studies evaluated tuberculosis risk in children who are HIV-exposed uninfected (cHEU) compared to HIV-unexposed uni…
New data shows that children exposed to HIV before birth have similar tuberculosis risks as children never exposed.
Community health workers support infectious disease management and PrEP navigation in agricultural communities
Community health workers help farm workers manage infectious diseases
This mini-review examines the role of community health workers (CHWs) in managing infectious diseases among California agricultural workers.…
Community health workers can help farm workers manage serious infections like HIV, tuberculosis, and hepatitis through direct outreach and n…
Short course regimens 3HP, 4HR, and 4R show higher adherence and lower active cases than 9H
Short Treatment Courses May Reduce Tuberculosis Cases in Children
This network meta-analysis evaluates treatment regimens for children and adolescents with TB infection. The study finds that 4HR reduces act…
New analysis suggests shorter drug regimens for children with tuberculosis may improve treatment completion and reduce the number of active …
Mtb antigen-induced IP-10 shows pooled sensitivity 0.81 and specificity 0.88 for latent TB
New Blood Test Marker Shows Promise for Detecting Hidden Tuberculosis Infections
This meta-analysis of 24 studies (2,014 participants) evaluated Mycobacterium tuberculosis antigen-induced interferon-gamma-inducible protei…
A new protein marker in the blood helps doctors identify people with hidden tuberculosis infections more accurately.
Comprehensive pulmonary rehabilitation may improve exercise capacity and quality of life in post-tuberculosis lung disease
Comprehensive Pulmonary Rehabilitation May Improve Life After Tuberculosis
This narrative review examines the role of comprehensive pulmonary rehabilitation for individuals with post-tuberculosis lung disease. The a…
Comprehensive pulmonary rehabilitation programs may improve exercise capacity and quality of life for people living with lung disease after …
Fluoroquinolone resistance acquired more frequently during TB treatment than other anti-TB drugs
Bacteria develop resistance to fluoroquinolones more often during tuberculosis treatment
This meta-analysis analyzed 5882 high-quality genomes from 1044 patients to identify MTBC mutations during infection and treatment. It found…
New data shows that tuberculosis bacteria develop resistance to fluoroquinolones more frequently than any other drug during treatment.
Questions about Pulmonary Tuberculosis
What factors help differentiate non-tuberculous mycobacterial disease from tuberculosis in patients?
NTM lung disease is more likely in older patients with bronchiectasis, COPD, or diabetes, and often shows thin-walled cavities on CT; TB-IGRA is usually negative in NTM.
Full answer →How well does a combined radiomics model distinguish tuberculosis from other lung lesions?
A combined radiomics model shows good accuracy (AP 0.85-0.91) for distinguishing tuberculosis from other lung lesions on CT, though performance drops in temporal validation (AP 0.62).
Full answer →Is the rate of confirmed pulmonary tuberculosis cases dropping in Hunan Province?
Data from Hunan Province shows the rate of confirmed pulmonary tuberculosis cases dropped by an average of 2.2% annually between 2009 and 2023, though the decline slowed after 2017.
Full answer →