Intensive Short-Term Dynamic Psychotherapy showed large effects on depression in treatment-resistant depression patients.
New Therapy Shifts How We Treat Stubborn Depression
This reanalysis of a randomized controlled trial (RCT) involving 86 patients with treatment-resistant depression compared Intensive Short-Te…
It started with a whisper. “I feel…
SCC DBS with at-home LFP data collection predicts stable recovery in treatment-resistant depression.
New brain signal predicts stable recovery for depression patients at home.
This cohort study evaluated ten SCC DBS participants with treatment-resistant depression. The intervention involved SCC DBS with at-home LFP…
A specific brain signal helps predict stable recovery in depression patients using at-home data, showing promise for better care.
Narrative review of TRD epidemiology and CYP2C19 genotypes in Pakistan
New Clue Reveals Why Depression Meds Fail Some People
This narrative review summarizes a genetic epidemiological study in Pakistan involving 3677 adults with major depressive disorder. It report…
A major study shows that genes and family support are key to treating depression.
Narrative review links ceramide elevations to major depressive disorder and suicidal vulnerability.
Fatty Acids in Blood May Signal Depression Risk
This narrative review examines circulating ceramide species in major depressive disorder, treatment-resistant depression, and suicidal vulne…
Your body's fat levels might hold the key to understanding why some depression cases are so hard to treat.
FDA Approves Spravato (esketamine) for Treatment-Resistant Depression and Depressive Symptoms with Acute Suicidal Ideation in Adults
The FDA approved a new nasal spray called Spravato for severe depression.
The FDA approved Spravato (esketamine) for treatment-resistant depression in adults as monotherapy or with an oral antidepressant, and for d…
FDA approved a new nasal spray for severe depression when other treatments fail or when patients face acute suicidal thoughts.
TAO-TMS shows high response rates in a small naturalistic Asian treatment-resistant depression cohort compared to historical controls.
Personalized TMS showed high response rates in a small Asian depression study
This study evaluated TAO-TMS, a personalized connectivity-guided accelerated iTBS protocol, in a naturalistic Asian population with treatmen…
A personalized magnetic stimulation method helped 70% of Asian patients with depression who had not responded to other treatments improve wi…
Ketogenic diet shows modest antidepressant benefit at 6 weeks in adults with treatment-resistant depression
Ketogenic diet shows modest benefit for treatment-resistant depression in small trial
In a randomized clinical trial of 88 UK adults with treatment-resistant depression, a ketogenic diet for 6 weeks led to a greater reduction …
A small UK trial found a strict low-carb diet offered slightly greater improvement in depression scores for adults who had not responded to …
Observational study links esketamine-induced mystical experiences to depression improvement in 45 patients
Mystical experiences during esketamine treatment linked to better depression outcomes in small study
In an observational study of 45 patients with treatment-resistant depression receiving esketamine at two centers, 58% experienced mystical e…
Patients with treatment-resistant depression who felt mystical effects from esketamine showed greater improvement, while other side effects …
Patient treatment preference does not affect outcomes in treatment-resistant depression, secondary analysis finds
Does getting your preferred depression treatment lead to better results?
A secondary analysis of an RCT involving 256 patients with treatment-resistant depression found that patient treatment preference (preferred…
For people with treatment-resistant depression, getting the specific therapy they prefer does not lead to better results than receiving a di…
Narrative review proposes combining rTMS and mindfulness for treatment-resistant depression
Could combining brain stimulation with mindfulness help stubborn depression?
A narrative review proposes that combining repetitive Transcranial Magnetic Stimulation (rTMS) with Mindfulness-Based Interventions (MBI) ma…
Combining brain stimulation with mindfulness might help stubborn depression by resetting brain circuits and building mental skills for lasti…