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Home › Conditions › Weight Loss

Weight Loss

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Weight Loss

88 trials tracked for Weight Loss: 7 in phase 3 or 4 and 5 with published results. The most-cited published study has 273 citations.

88Trials tracked
7Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 3 Phase 3 4 Phase 2 6 Other / NA 75
  1. Phase 4 Liraglutide in Obesity and Diabetes: Identification of CNS Targets Using fMRI Completed · 273 cited
  2. Phase 3 Opt-IN: Optimization of Remotely Delivered Intensive Lifestyle Treatment for Obesity Completed · 68 cited
  3. Phase 3 The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects Completed · 39 cited
  4. Phase 4 Saxenda in Obesity Services (STRIVE Study) Completed · 18 cited
  5. Phase 4 Weight Loss With Risedronate for Bone Health Completed · 11 cited
  6. Phase 3 Behavioral Mechanism of Energy Compensation With Exercise Completed
Show 44 more trials
  1. Phase 3 Safety and Efficacy of IQP- AK-102 in Reducing Body Weight Completed
  2. Phase 2 Topiramate in Adolescents With Severe Obesity Completed
  3. Phase 2 Obinutuzumab and Lenalidomide in Treating Patients With Previously Untreated Stage II-IV Grade 1-3a Follicular Lymphoma Completed
  4. Phase 2 Qsymia as an Adjunct to Surgical Therapy in the Superobese Completed
  5. Phase 2 Evaluation of Safety, Efficacy and Thermogenesis-induction of RZL-012 in Overweight and Obese Volunteers Completed
  6. Phase 2 Ex Vivo-activated Autologous Lymph Node Lymphocytes in Treating Patients With Chronic Lymphocytic Leukemia Completed
  7. Phase 2 Does Dapagliflozin Provide Additional Health Benefits To Dietary Counseling For Weight Loss? Completed
  8. N/A Testing the Effectiveness of WW Clinic GLP1 Completed
  9. N/A The Healthy Moms Study: Comparison of a Post-Partum Weight Loss Intervention Delivered Via Facebook or In-Person Groups Completed
  10. N/A Psychological Intervention to Reduce Weight Bias Internalization Completed
  11. N/A Engaging Rural Men With Mobile Technologies for Weight Loss Completed
  12. N/A Weight Management in Rural Communities Completed
  13. N/A Our Lifestyles Our Lives Completed
  14. N/A Effect of Caloric Restriction and Protein Intake on Metabolism and Anabolic Sensitivity Completed
  15. N/A University Of Pennsylvania Weight Loss Study Completed
  16. N/A The Personalized Nutrition Study Completed
  17. N/A Gestational Weight Gain and Postpartum Weight Loss in Active Duty Women (Moms Fit 2 Fight) Completed
  18. N/A A Single-Group Study to Examine the Efficacy of a Gut Health Supplement to Increase Metabolism, Improve Gut Health, and Support Weight Management Completed
  19. N/A Bariatric Embolization of Arteries With Imaging Visible Embolics (BEATLES) Completed
  20. N/A Alternate Day Fasting for Weight Loss, Weight Maintenance and Cardio-protection Completed
  21. N/A Low Indexes of Metabolism - Information to Teams (LIMIT) Completed
  22. N/A TOPS for African American Breast Cancer Survivors Completed
  23. N/A FitLink: Improving Weight Loss Maintenance by Using Digital Data to Provide Support and Accountability Completed
  24. N/A Project Activate: Mindfulness and Acceptance Based Behavioral Treatment for Weight Loss Completed
  25. N/A Project Impact: An Innovative Approach to Weight Loss Maintenance Completed
  26. N/A Rural Disparities in Pediatric Obesity: The iAmHealthy Intervention Completed
  27. N/A Breastfeeding and Exercise for Healthy Infants and Postpartum Moms Too! Completed
  28. N/A A Trial to Test an Acceptance-based Therapy Program Among Adolescent Girls With Overweight/Obesity Completed
  29. N/A Behavioral Activation for Smoking Cessation and the Prevention of Post-Cessation Weight Gain Completed
  30. N/A Online Family Dyadic Skills Training for Black Adults in Behavioral Weight Loss Program Completed
  31. N/A Total Lifestyle Coaching Pilot Study (TLC) Completed
  32. N/A Esophageal Cytology With FISH in Detecting Esophageal Cancer Completed
  33. N/A Effect of High Protein Weight Loss for Seniors Completed
  34. N/A Low-level Laser and Lifestyle Modifications Completed
  35. N/A Physical and Cognitive Function - Look AHEAD Ancillary Study Completed
  36. N/A Delicious Eating for Life in Southern Homes Completed
  37. N/A Effectiveness and Cost-Effectiveness of Fully-Automated Digital vs. Human Coach-Based Diabetes Prevention Programs Completed
  38. N/A Weight Loss Study-Mechanism Underlying the Improvement of Insulin Resistance in Response to Weight Loss Completed
  39. N/A Feasibility of a Campaign Intervention Compared to a Standard Behavioral Weight Loss Intervention in Overweight and Obese Adults Completed
  40. N/A Self-Weighing Instruction Feasibility Study Completed
  41. N/A Lifestyle Behavior Weight Loss Intervention Completed
  42. N/A Utilizing Protein During Weight Loss to Impact Physical Function Completed
  43. N/A An Evaluation of the Effect of the Erchonia Laser for Non-invasive Reduction of Submental Fat Completed
  44. N/A Investigating the Physiological Effects of Weight Loss on Male Fertility Completed

Showing the 50 most-cited and recently-updated of 88 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Weight Loss: what the trials found

Pharmacological interventions have demonstrated varying effects on weight management. Saxenda showed significant results for achieving a weight loss of ≥15% from baseline in both Intention to Treat (p<0.001) and Per Protocol (p=0.002) analyses 5. Byetta (exenatide) was associated with a statistically significant reduction in body weight (p=0.05) alongside significant reductions in energy intake (p=0.01) and 24-hour energy expenditure (p=0.01) 8.

Non-pharmacological interventions also show evidence of efficacy. Telephone coaching sessions resulted in a statistically significant reduction in weight by month 6 (p<0.001) 7. Additionally, exercise was evaluated as an intervention for this condition 9.

Recent results — preliminary, needs further review

  • Med-South Weight Loss Intervention showed statistically significant percent weight changes at months 4 and 12 (p<0.0001) 21.
  • Mindfulness Orientated Recovery Enhancement resulted in a statistically significant reduction in body weight (p<0.001) 19.
  • A study on weight loss percentage change from week 0 to 24 reported values of 161, 121, 81, and 20 17.
  • Community-based mentoring and education sessions were evaluated for changes in waist circumference and 'Life's Simple 6' composite scores 3.
  • A digital diabetes prevention program (dDPP) showed a statistically significant achievement of CDC benchmarks for type 2 diabetes risk reduction (p<0.05) despite a modest percentage change in weight [-1.03; -1.43] 18.

For the clinician treating this condition

  • Saxenda is associated with statistically significant achievement of ≥15% weight loss in both ITT and Per Protocol analyses.
  • Exenatide (Byetta) significantly reduces body weight while simultaneously decreasing energy intake and expenditure.
  • Telephone coaching and exercise are established non-pharmacological interventions for weight management.

AI synthesis of 9 cited trials, updated Jun 27, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Observational registry finds 29% hospital-associated disability in older Japanese rehabilitation patients
Physical Medicine & Rehab
Observational registry finds 29% hospital-associated disability in older Japanese rehabilitation patients Study establishes registry tracking disability in older hospital patients
A prospective multicenter observational study of 209 patients aged ≥70 years in Japanese rehabilitation wards established a hospital-associa…
A new tracking system reveals that nearly 30% of older patients lose independence during hospital stays, while most also lose weight.
medRxiv Apr 3, 2026