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Home › Medications › aspirin

aspirin

23 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of aspirin

101 trials tracked of aspirin: 52 in phase 3 or 4 and 23 with published results. The most-cited published study has 2401 citations.

101Trials tracked
52Phase 3 & 4
0Recruiting
23With published results
Phase distribution
Phase 4 28 Phase 3 24 Phase 2 32 Phase 1 5 Other / NA 12
  1. Phase 3 Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease Completed · 2,401 cited
  2. Phase 4 Determining Genetic Role in Treatment Response to Anti-Platelet Interventions (The PAPI Study) Completed · 1,502 cited
  3. Phase 3 Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT) Completed · 280 cited
  4. Phase 4 Different Antiplatelet Therapy Strategy After Coronary Artery Bypass Graft Surgery Completed · 237 cited
  5. Phase 3 Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET) Completed · 171 cited
  6. Phase 3 PREVENTion of Clot in Orthopaedic Trauma Completed · 152 cited
Show 44 more trials
  1. Phase 4 Nephropathy In Type 2 Diabetes and Cardio-renal Events Completed · 129 cited
  2. Phase 3 Pharmacokinetic, Pharmacodynamic, Safety, and Efficacy Study of Rivaroxaban for Thromboprophylaxis in Pediatric Participants 2 to 8 Years of Age After the Fontan Procedure Completed · 92 cited
  3. Phase 3 Minocycline and Aspirin in the Treatment of Bipolar Depression Completed · 72 cited
  4. Phase 3 GLOBAL LEADERS: A Clinical Study Comparing Two Forms of Anti-platelet Therapy After Stent Implantation Completed · 50 cited
  5. Phase 3 Low Dose Aspirin for Venous Leg Ulcers Completed · 29 cited
  6. Phase 3 Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI) Completed · 24 cited
  7. Phase 4 Vorapaxar in Patients With Prior Myocardial Infarction Treated With Prasugrel and Ticagrelor Completed · 22 cited
  8. Phase 3 Microvascular and Antiinflammatory Effects of Rivaroxaban Compared to Aspirin in Type-2 Diabetic Patients With Subclinical Inflammation and High Cardiovascular Risk Completed · 20 cited
  9. Phase 4 Vorapaxar as an Add-On Antiplatelet Therapy in Patients With and Without Diabetes Mellitus Completed · 19 cited
  10. Phase 4 PROMUS Element Plus US Post-Approval Study Completed · 16 cited
  11. Phase 3 Comparative Efficacy of Ticagrelor Versus Aspirin on Blood Viscosity in Peripheral Artery Disease Patients With Type 2 Diabetes Completed · 13 cited
  12. Phase 4 Clopidogrel and Aspirin Interaction Study-2 Completed · 11 cited
  13. Phase 4 Switching From DAPT to Dual Pathway Inhibition With Low-dose Rivaroxaban in Adjunct to Aspirin in Patients With Coronary Artery Disease Completed · 10 cited
  14. Phase 4 A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart Completed · 9 cited
  15. Phase 4 Ticagrelor Antiplatelet Therapy to Reduce Graft Events and Thrombosis Completed · 9 cited
  16. Phase 4 Ticagrelor With Aspirin or Alone in High-Risk Patients After Coronary Intervention Completed · 7 cited
  17. Phase 3 Low Doses of Aspirin in the Prevention of Preeclampsia Completed · 4 cited
  18. Phase 4 Phase 4 Study of Effect of Aspirin on Flushing in Dimethyl Fumarate-Treated Participants With Relapsing-Remitting Multiple Sclerosis Completed
  19. Phase 4 Pharmacogenomics of Antiplatelet Response - II (PARes-II) Completed
  20. Phase 4 Pharmacogenomics of Antiplatelet Response Completed
  21. Phase 4 Pharmacogenomics of Antiplatelet Response - I Completed
  22. Phase 4 DOACs for Stroke Prevention Post Ventricular Tachycardia Ablation Completed
  23. Phase 4 Aspirin for Prevention of Venous Thromboembolism Among Ovarian Cancer Patients Receiving Neoadjuvant Chemotherapy Completed
  24. Phase 4 CES1 Carriers in the PAPI Study Completed
  25. Phase 4 The Impact of Aspirin Dose Modification on the Innate Immune Response - Will Lower Dose Aspirin Therapy Reduce the Response to Endotoxin Completed
  26. Phase 4 Aspirin Dosing in Diabetic Patients Completed
  27. Phase 4 Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2) Completed
  28. Phase 4 A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers Completed
  29. Phase 4 Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome Completed
  30. Phase 4 Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression of Peripheral Arterial Disease (The ELIMIT Study) Completed
  31. Phase 4 Effect of Cilostazol in the Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler Completed
  32. Phase 4 Aspirin Responsiveness in Women at Risk for Cardiac Events Completed
  33. Phase 4 Pilot Study Evaluating Alterations in Thrombogenicity and Platelet Reactivity Following Lower Extremity Arthroplasty Completed
  34. Phase 4 Aspirin Dose and Atherosclerosis in Patients With Heart Disease Completed
  35. Phase 3 A Study on the Use of Tanakan® for Recovery of Neurological Impairment Following Ischaemic Stroke Completed
  36. Phase 3 Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis Completed
  37. Phase 3 Omega-3 Plus Low-dose Aspirin Daily Supplementation in Non-surgical Therapy to Treat Aggressive Periodontitis Completed
  38. Phase 3 Aspirin in Young Psychotic Patients Completed
  39. Phase 3 A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia Completed
  40. Phase 3 PLATINUM Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions-Pharmacokinetics (PLATINUM PK) Completed
  41. Phase 3 A Study to Compare MPR With MP in Newly Diagnosed Multiple Myeloma Subjects 65 Years Old or Older. Completed
  42. Phase 3 Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial Completed
  43. Phase 3 The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of De Novo Coronary Artery Lesions Completed
  44. Phase 3 The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of Long De Novo Coronary Artery Lesions (PLATINUM LL) Completed

Showing the 50 most-cited and recently-updated of 101 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Aspirin and NSAIDs show little benefit for colorectal cancer prevention within 15 years but increase bleeding risk
Oncology Meta-analysis
Aspirin and NSAIDs show little benefit for colorectal cancer prevention within 15 years but increase bleeding risk The Aspirin-Cancer Question Has a Complicated Answer
This Cochrane meta-analysis of randomized controlled trials involving 124,837 participants evaluated aspirin and nonsteroidal anti-inflammat…
A major new review finds that taking daily aspirin to prevent colon cancer offers little benefit for the first 15 years while increasing ble…
Apr 14, 2026
Ten-year HOST-EXAM trial data show clopidogrel reduces major adverse events versus aspirin in chronic PCI maintenance
Cardiology RCT
Ten-year HOST-EXAM trial data show clopidogrel reduces major adverse events versus aspirin in chronic PCI maintenance Long-term clopidogrel may lower risks compared to aspirin after heart stents
This 10-year extended follow-up of the HOST-EXAM randomized controlled trial evaluated clopidogrel versus aspirin in 5,438 patients during t…
After heart stents, long-term clopidogrel alone lowered risks of major heart events and death compared to aspirin alone in a 10-year study.
Apr 14, 2026
Systematic review links neutrophil extracellular trap dysregulation to pregnancy complications
Diabetes & Endocrinology Sys. Review
Systematic review links neutrophil extracellular trap dysregulation to pregnancy complications Web of White Blood Cells Linked to Pregnancy Risks
A systematic review of emerging evidence indicates that dysregulation of neutrophil extracellular trap (NET) formation and clearance is stro…
A sticky web of white blood cells meant to fight germs can instead trigger serious pregnancy risks like preeclampsia and preterm birth when …
Frontiers Apr 12, 2026
Ticagrelor Not Noninferior to Prasugrel in Diabetes Patients With Multivessel CAD After PCI
Cardiology RCT
Ticagrelor Not Noninferior to Prasugrel in Diabetes Patients With Multivessel CAD After PCI New study shows ticagrelor did not beat prasugrel for heart attack prevention in diabetics
This randomized clinical trial of 1,800 patients with diabetes and multivessel coronary artery disease undergoing PCI compared ticagrelor pl…
For diabetics with heart stents, a new study found ticagrelor offered no clear advantage over prasugrel in preventing death, heart attacks, …
JAMA Cardiol Apr 9, 2026
Adding low-dose rivaroxaban to DAPT did not significantly reduce LV thrombus in anterior STEMI patients
Cardiology RCT
Adding low-dose rivaroxaban to DAPT did not significantly reduce LV thrombus in anterior STEMI patients Adding low-dose rivaroxaban to standard heart attack drugs did not clearly prevent blood clots in the heart
This randomized clinical trial evaluated 560 patients with anterior ST-segment elevation myocardial infarction (STEMI) across 29 centers in …
Adding a low-dose blood thinner to standard heart attack drugs did not clearly prevent dangerous clots in the heart, based on a trial of 560…
JAMA Cardiol Apr 9, 2026
Tirofiban plus aspirin associated with lower early neurological deterioration in branch atheromatous disease
Neurology Cohort
Tirofiban plus aspirin associated with lower early neurological deterioration in branch atheromatous disease Early tirofiban plus aspirin linked to fewer early neurological declines in branch atheromatous disease patients
A retrospective single-center cohort study in patients with acute branch atheromatous disease found early tirofiban plus aspirin was associa…
Early tirofiban plus aspirin reduced early neurological decline from 55.1% to 10.1% in branch atheromatous disease patients compared to stan…
Frontiers Apr 9, 2026
Lp-PLA2 activity does not significantly modify dual antiplatelet therapy efficacy in minor stroke/TIA with CYP2C19 loss-of-function alleles
Neurology RCT
Lp-PLA2 activity does not significantly modify dual antiplatelet therapy efficacy in minor stroke/TIA with CYP2C19 loss-of-function alleles Blood enzyme levels don't change which stroke prevention drug works better, study finds
This subgroup analysis of the CHANCE-2 RCT examined 5919 patients with minor stroke/TIA and CYP2C19 loss-of-function alleles.
A simple blood test for inflammation doesn't predict which stroke prevention drug works best for patients with a specific genetic trait.
Apr 5, 2026
Protocol for argatroban plus clopidogrel versus aspirin plus clopidogrel in acute minor ischemic stroke
Neurology RCT
Protocol for argatroban plus clopidogrel versus aspirin plus clopidogrel in acute minor ischemic stroke Study will compare two blood thinner combinations for minor strokes
This is a study protocol for a randomized controlled trial of 464 patients with acute minor ischemic stroke (NIHSS ≤5) within 72 hours.
A new trial will test if adding argatroban to clopidogrel leads to better recovery than aspirin plus clopidogrel for minor stroke patients.
medRxiv Apr 4, 2026
Post hoc analysis finds cilostazol reduces stroke recurrence without lowering systolic blood pressure
Neurology RCT
Post hoc analysis finds cilostazol reduces stroke recurrence without lowering systolic blood pressure Study finds cilostazol reduces stroke recurrence without lowering blood pressure
A post hoc mediation analysis of an RCT in 1,795 patients with noncardioembolic ischemic stroke found dual therapy with cilostazol plus…
Cilostazol lowers stroke recurrence risk in patients with prior noncardioembolic strokes without working by dropping their blood pressure.
Apr 3, 2026
Adjuvant NSAIDs associated with improved DFS in resected PIK3CA-mutated colorectal cancer
Gastroenterology Meta-analysis
Adjuvant NSAIDs associated with improved DFS in resected PIK3CA-mutated colorectal cancer NSAID therapy after surgery may help prevent colorectal cancer recurrence in some patients
A meta-analysis of 789 patients with resected PIK3CA-mutated colorectal cancer found adjuvant NSAID therapy (aspirin or COX-2 inhibitors) wa…
Taking anti-inflammatory drugs like aspirin after colorectal cancer surgery may lower the risk of the cancer returning in patients with a sp…
Apr 2, 2026
Phase 2 Trial: Cytisine and ASA for Inflammation in Lifelong Smokers
Pulmonology & Critical Care Phase II
Phase 2 Trial: Cytisine and ASA for Inflammation in Lifelong Smokers Can quitting smoking and changing your diet really reduce lung inflammation?
A Phase 2 trial evaluates cytisine for smoking cessation and ASA for inflammation in 2000 lifelong smokers.
Quitting smoking, eating better, and moving more can reduce lung inflammation in lifelong smokers, offering a path to breathe easier and low…
CT.gov Mar 28, 2026