Belantamab mafodotin plus lenalidomide and dexamethasone shows high response in unfit multiple myeloma
Early trial shows promising results for a new drug combination in frail multiple myeloma patients
A Phase 1/2 randomized controlled trial in 42 RP2D patients with unfit, transplant-ineligible newly diagnosed multiple myeloma found an over…
A new drug combination helped 97.6% of frail multiple myeloma patients respond to treatment while keeping eye side effects manageable.
RCD chemotherapy in Waldenström macroglobulinemia with AL amyloidosis led to rapid progression and death
Rare Blood Cancer Causes Fast Kidney Failure
This case report and literature review describes a 75-year-old female with Waldenström macroglobulinemia and AL lambda-type amyloid nephropa…
When a rare blood cancer attacks the kidneys, standard treatments often fail to stop the fast progression to organ failure.
Network meta-analysis compares 5-HT3 antagonists with or without dexamethasone for highly emetogenic chemotherapy-induced nausea and vomiting
New analysis suggests palonosetron plus dexamethasone may reduce delayed vomiting in chemotherapy patients
This network meta-analysis evaluated 5-hydroxytryptamine-3 (5-HT3) receptor antagonists with or without dexamethasone in patients undergoing…
Combining palonosetron with dexamethasone reduces delayed vomiting in chemotherapy patients better than other common drug options.
Carfilzomib-lenalidomide-dexamethasone improves progression-free survival versus lenalidomide after transplant in multiple myeloma
Adding carfilzomib to lenalidomide improved survival in multiple myeloma patients after stem cell transplant
In a phase 3 trial of 180 patients with newly diagnosed multiple myeloma after autologous HSCT, carfilzomib-lenalidomide-dexamethasone maint…
Adding carfilzomib to lenalidomide after stem cell transplant boosted four-year survival to 67.5% compared to 38.0% for patients on lenalido…
Systemic glucocorticoid exposure in children linked to reversible myocardial hypertrophy, subclinical cardiac changes
Review finds reversible heart changes in children taking certain steroid medications
A narrative review of pediatric systemic glucocorticoid exposure found the most consistent structural signal is time-locked, reversible myoc…
Certain steroid medicines used for childhood illnesses can temporarily thicken the heart muscle in very young babies, but this change appear…
Topical dexamethasone mouthwash reduces oral mucositis severity in head and neck cancer radiotherapy patients
Can a simple mouthwash prevent the painful mouth sores of cancer radiation?
A phase II randomized controlled trial of 50 patients with head and neck cancer receiving ≥60 Gy radiotherapy found prophylactic topical dex…
Rinsing with a steroid mouthwash during head and neck cancer radiation reduced severe mouth sores, delayed pain peaks, and prevented the wor…
Observational study explores daratumumab resistance mechanisms in primary light-chain amyloidosis
Small study links daratumumab resistance to immune changes in light-chain amyloidosis
An observational cohort study of 30 patients with primary light-chain amyloidosis treated with daratumumab-bortezomib-dexamethasone found th…
Patients with weaker responses to amyloidosis treatment showed lower gene activity before therapy and increased immune stress during treatme…
Observational report describes racial and ethnic disparities in receiving COVID-19 treatment medications in the US
Report describes racial and ethnic disparities in receiving COVID-19 treatment medications
An observational report from the United States described racial and ethnic disparities in the receipt of medications for COVID-19 treatment.
A new report describes racial and ethnic disparities in receiving medications for COVID-19 treatment in the United States.
Real-world study shows lenalidomide-dexamethasone yields 22.9-month PFS in transplant-ineligible myeloma
Real-world study shows lenalidomide treatment outcomes for older multiple myeloma patients
A prospective, non-interventional study of 168 transplant-ineligible NDMM patients in Germany found median PFS of 22.9 months and OS of 58.1…
Real-world data shows lenalidomide plus low-dose dexamethasone keeps older multiple myeloma patients disease-free for nearly two years while…
Antenatal dexamethasone reduces respiratory support need in late preterm infants in Vietnamese RCT
Can a steroid shot before late preterm birth help babies breathe easier?
A randomized controlled trial of 294 pregnant women at risk of late preterm delivery in Vietnam found antenatal dexamethasone reduced infant…
Giving mothers a steroid shot before late preterm birth cut the need for breathing support in babies by nearly 10%, reducing hospital stays …
Perineural dexamethasone extends analgesia duration in upper limb surgery blocks versus bupivacaine alone
Can a common steroid make pain relief from arm surgery last longer?
A double-blinded RCT in 90 ASA I/II patients undergoing upper limb procedures found adding 4 mg perineural dexamethasone to bupivacaine sign…
Adding a tiny amount of common steroid dexamethasone to arm surgery numbing shots nearly doubled pain relief time to over 20 hours with few …
Daratumumab + Len/Dex shows ORR in relapsed/refractory multiple myeloma phase 1/2 trial
Can a new drug combination help people with multiple myeloma that has returned after treatment?
This phase 1/2 study evaluated daratumumab in combination with lenalidomide and dexamethasone in patients with relapsed or relapsed-refracto…
A new three-drug combination of daratumumab, lenalidomide, and dexamasone showed safety and response in people with relapsed multiple myelom…