Targeted therapy plus dexamethasone resolves S. suis meningitis without surgery in case report
Man's S. suis Meningitis Resolved Without Surgery
This case report describes a 52-year-old man with Streptococcus suis meningitis and hydrocephalus who achieved complete clinical and radiolo…
A 52-year-old man with S. suis meningitis and hydrocephalus recovered fully without surgery, keeping his hearing intact.
D-VCd improves hematologic CR rate to 59.5% compared to 19.2% in AL amyloidosis
Trial shows adding daratumumab improves outcomes for AL amyloidosis
This Phase 3 randomized controlled trial of 388 patients with newly diagnosed AL amyloidosis found that adding subcutaneous daratumumab to V…
Adding daratumumab to a standard drug combination helps patients with AL amyloidosis achieve faster and deeper responses in blood and organ …
D-VRd ranks highest for progression-free survival among anti-CD38 regimens in transplant-ineligible multiple myeloma
New data ranks best treatments for transplant-ineligible multiple myeloma
This network meta-analysis of 6 trials involving 3162 patients evaluated various treatment nodes for transplant-ineligible newly diagnosed m…
A large review of 3,162 patients reveals which combinations of drugs work best to keep multiple myeloma from progressing.
Prophylactic dexamethasone reduces risk of radiation induced pain flares in patients with bone metastases
Dexamethasone reduces radiation induced pain for bone metastasis patients
This meta-analysis evaluated the use of prophylactic dexamethasone in patients with bone metastases undergoing palliative radiotherapy. The …
A steroid treatment may help prevent sudden spikes in pain for patients receiving radiation therapy for cancer that has spread to the bone.
Low-dose oral dexamethasone is comparable to high-dose dexamethasone for managing children with croup
Low dose dexamethasone works as well as high dose for croup
This meta-analysis of 1,058 children evaluated the efficacy of low-dose oral dexamethasone compared to a high-dose regimen. The study found …
A lower dose of the steroid dexamethasone may be just as effective as a higher dose for treating mild to moderate croup in children.
Reduced-dose daratumumab and bortezomib may achieve partial renal remission in CyBorD-refractory PGNMID
Reduced Dose Daratumumab Shows Promise for Rare Kidney Disease
This case report describes a 73-year-old male with proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) who ach…
A new case report shows a reduced dose of daratumumab may help manage severe kidney disease and heart failure in high-risk elderly patients.
Intraoperative dexamethasone increases maximum perioperative blood glucose by 1.86 mM in patients with diabetes
Trial shows Dexamethasone impacts blood sugar during surgery for diabetes
This randomized controlled trial of 1130 people with diabetes and glycated haemoglobin <9.0% found that a single 8 mg dose of intraoperative…
A new study shows that a single dose of dexamethasone can raise blood glucose levels in patients with diabetes undergoing nonurgent surgery.
IV-PEG asparaginase compared to IM-EC in children with acute lymphoblastic leukemia
PEG-asparaginase shows lower toxicity in childhood leukemia trial
This Phase 3 randomized controlled trial evaluated intravenous PEG-asparaginase (IV-PEG) versus intramuscular native E. coli L-asparaginase …
A new trial finds that PEG-asparaginase may cause fewer side effects than standard treatment for children with leukemia.
Bortezomib, cyclophosphamide, and dexamethasone achieved remission in a patient with AL amyloidosis and POEMS syndrome
Treatment shows success for heart failure and rare blood diseases
This case report and literature review describes the treatment of an elderly male with concurrent AL amyloidosis and POEMS syndrome. The pat…
A new look at a complex case reveals how a specific drug combination helped an elderly man with multiple rare conditions.
Carbonic anhydrase inhibitors and DEXi show superior CMT reduction in retinitis pigmentosa macular oedema
New Analysis Compares Treatments for Retinitis Pigmentosa Macular Oedema
This network meta-analysis evaluates various treatments for retinitis pigmentosa (RP)-associated macular oedema. The study found that carbon…
Different medications show varying success in reducing swelling and improving vision for patients with retinitis pigmentosa-associated macul…
Anti-VEGF plus corticosteroids improves BCVA and reduces edema recurrence in BRVO and CRVO
Combination therapy improves vision for patients with retinal vein occlusion
This meta-analysis of 2040 patients found that anti-VEGF plus corticosteroid combination therapy resulted in better BCVA (MD -0.09) and redu…
Adding corticosteroids to anti-VEGF injections can improve vision and reduce the need for frequent eye injections in certain retinal conditi…
101-PGC-005 achieves HR 2.31 for faster WHO scale improvement over dexamethasone in COVID-19
New drug beats dexamethasone for moderate COVID-19 recovery
This randomized Phase II/III trial of 309 hospitalized patients with moderate COVID-19 found that 101-PGC-005 (20 mg IV daily for 3 days) si…
A new drug helped hospitalized COVID-19 patients recover a day faster than dexamethasone, with similar safety.