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Home › Medications › dexmedetomidine

dexmedetomidine

26 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of dexmedetomidine

103 trials tracked of dexmedetomidine: 56 in phase 3 or 4 and 19 with published results. The most-cited published study has 313 citations.

103Trials tracked
56Phase 3 & 4
0Recruiting
19With published results
Phase distribution
Phase 4 37 Phase 3 19 Phase 2 15 Phase 1 5 Other / NA 27
  1. Phase 4 Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery Completed · 313 cited
  2. Phase 3 The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure Completed · 289 cited
  3. Phase 3 Intranasal Dexmedetomidine Premedication in Children Completed · 288 cited
  4. Phase 4 Dexmedotomidine for Acute Pain Control in Patients With Multiple Rib FracturesRandomized Controlled Trial Completed · 203 cited
  5. Phase 3 Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep Completed · 68 cited
  6. Phase 4 UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study Completed · 66 cited
Show 44 more trials
  1. Phase 4 Dexmedetomidine Versus Morphine and Midazolam in Prevention and Treatment of Delirium After Adult Cardiac Surgery Completed · 51 cited
  2. Phase 4 Can Dexmedetomidine For Procedural Sedation In Knee Arthroplasty Reduce Postoperative Pain? A Randomized Control Study Completed · 40 cited
  3. Phase 4 Influence of Dexmedetomidine and Lidocaine on Opioid Consumption in Laparoscopic Intestine Resection Completed · 30 cited
  4. Phase 4 Cognitive Functions After TIVA With Dexmedetomidine Completed · 26 cited
  5. Phase 4 The Synergistic Effect of Dexmedetomidine on Propofol for Sedation for Pediatric Endoscopy Completed · 22 cited
  6. Phase 3 Effects of Dexmedetomidine on Delirium Duration of Non-intubated ICU Patients (4D Trial) Completed · 22 cited
  7. Phase 4 Evaluation of Dexmedetomidine on Post-operative Narcotic Requirements and Pain Scores in Bariatric Patients Completed · 21 cited
  8. Phase 4 The Effects of Dexmedetomidine on the Heart Beat During Elective Surgery in Children Completed · 13 cited
  9. Phase 3 Study of DA-9501 In Pediatric Subjects In The Intensive Care Unit Completed · 10 cited
  10. Phase 4 Effects of Dexmedetomidine on Activity in the Subthalamic Nucleus Completed · 7 cited
  11. Phase 3 Self-management of Sedative Therapy by Ventilated Patients Completed · 4 cited
  12. Phase 3 Clinical Study to Investigate the Efficacy and the Safety of DA-9501 in Sedation During the Surgery With Epidural Anesthesia or Spinal Anesthesia Without Intubation Completed · 3 cited
  13. Phase 4 Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy Completed · 2 cited
  14. Phase 4 Intranasal Dexmedetomidine vs Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair Completed
  15. Phase 4 Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion Completed
  16. Phase 4 The Effect of Dexmedetomidine Infusion on Post-operative Cognitive Function and Oxidative Stress in Cardiac Surgery Completed
  17. Phase 4 Effect of Dexmedetomidine on Emergence Agitation in Children With or Without Tube Insertion Under General Anesthesia Completed
  18. Phase 4 Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy Completed
  19. Phase 4 Dexmedetomidine and Propofol for Pediatric MRI Sedation Completed
  20. Phase 4 Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure Completed
  21. Phase 4 the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block Completed
  22. Phase 4 Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels. Completed
  23. Phase 4 Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans Completed
  24. Phase 4 Study on the Effects of Intravenous Dexmedetomidine on Pain in Patients Undergoing Elective Spinal Surgery Completed
  25. Phase 4 Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF Surgery Completed
  26. Phase 4 Multimodal Versus Opioid aNalgesia in carDiAc Surgery Completed
  27. Phase 4 Effect of Dexmedetomidine of Gastrointestinal Motility Completed
  28. Phase 4 Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea Completed
  29. Phase 4 Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis Completed
  30. Phase 4 Dexmedetomidine vs Fentanyl for BMT Completed
  31. Phase 4 Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy Completed
  32. Phase 4 A Trial Of Oral Chloral Hydrate Versus Intranasal Dexmedetomidine For Sedated Abr Exams Completed
  33. Phase 4 Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids Completed
  34. Phase 4 Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block Completed
  35. Phase 4 Dexmedetomidine to Prevent Agitation After Free Flap Surgery Completed
  36. Phase 4 Dexmedetomidine for Immediate Perioperative Analgesia in Pediatric Patients Undergoing Tonsillectomy Completed
  37. Phase 4 Efficacy of Single-Shot Dexmedetomidine Versus Placebo in Preventing Pediatric Emergence Delirium in Strabismus Surgery Completed
  38. Phase 4 Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Subjects Undergoing Procedure-Type Sedation Completed
  39. Phase 3 Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy Completed
  40. Phase 3 Use of Dexmedetomidine to Reduce Emergence Delirium Incident in Children Completed
  41. Phase 3 Dexmedetomidine to Treat Bariatric Surgery-associated Pain Completed
  42. Phase 3 Placebo Controlled Clinical Trial of the Postoperative Opioid Sparing Effects of Intraoperative Dexmedetomidine Infusion for Thoracic Surgery Completed
  43. Phase 3 Sedation Using Intranasal Dexmedetomidine in Upper Gastrointestinal Endoscopy Completed
  44. Phase 3 Neuroimaging Study of Dexmedetomidine-Induced Analgesia Completed

Showing the 50 most-cited and recently-updated of 103 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Benzodiazepines, Dexmedetomidine, and Physical Restraints Associated with Next-Day Delirium in Critically Ill Children
Pediatrics RCT
Benzodiazepines, Dexmedetomidine, and Physical Restraints Associated with Next-Day Delirium in Critically Ill Children Study finds link between certain medications, restraints, and delirium in critically ill children
A secondary analysis of a pilot RCT dataset in 1,006 critically ill children across seven PICUs found previous-day benzodiazepine and dexmed…
Higher doses of sedatives like midazolam and any use of physical restraints are linked to increased confusion in critically ill children the…
Apr 3, 2026
Ketamine may reduce positional pain more than dexmedetomidine or nerve block in femur fracture patients
Orthopedics & Sports Medicine RCT
Ketamine may reduce positional pain more than dexmedetomidine or nerve block in femur fracture patients Which drug works best for pain when positioning patients with broken hips?
A 75-patient RCT compared IV ketamine (0.3 mg/kg), IV dexmedetomidine (0.5 μg/kg), and femoral nerve block for analgesia during positioning …
Ketamine outperformed nerve blocks and dexmedetomidine for reducing severe pain when positioning patients with broken hips before surgery.
Apr 2, 2026