Multi-target therapies may address combined hypertension and dyslipidemia pathophysiology
Multi-Target Therapies May Address Combined Hypertension and High Cholesterol
This systematic review synthesizes evidence on synergistic mechanisms of hypertension and dyslipidemia, highlighting the RAAS/PPAR axis, AMP…
Combining treatments like statins and RAAS inhibitors may offer a more precise way to manage both high blood pressure and cholesterol levels…
Research in coronary heart disease shows misalignment between investment and clinical guideline priorities
China's heart disease research focuses on bioequivalence, not innovation
This guideline-based research trend analysis of 3,339 publications identifies a significant gap between current research investments and cli…
A review of 3,339 publications shows China's coronary heart disease research heavily emphasizes bioequivalence studies over innovative drug …
Microcirculatory dysfunction during cardiac surgery remains heterogeneous and inconclusive in current clinical evidence
Microcirculation in Cardiac Surgery: What We Know and What Remains Unclear
This narrative review examines microcirculatory dysfunction in patients undergoing cardiac surgery with cardiopulmonary bypass. The authors …
A review of cardiac surgery research shows mixed results on microcirculation, with many gaps between lab findings and patient care.
Statins reduce recurrence risk 23% and mortality in 267,913 HR+ breast cancer patients with HR 0.77
Statins lower recurrence and death risk in hormone receptor-positive breast cancer
This systematic review and meta-analysis evaluated statin use versus non-use in 267,913 patients with hormone receptor-positive breast cance…
A massive analysis of over 267,000 patients shows statins reduce recurrence and death risk in hormone receptor-positive breast cancer.
Narrative review suggests precision interventions for preeclampsia phenotypes
At-a-Glance
This narrative review examines prevention strategies for preeclampsia in pregnant women. The authors note that standard low-dose aspirin eff…
Preeclampsia prevention is moving beyond aspirin for everyone, with new research showing that matching treatments to a woman's specific risk…
Meta-analysis on Tongxinluo plus statins for carotid atherosclerosis
Herbal Combo Shrinks Dangerous Neck Artery Plaques Faster
This meta-analysis of 4,175 patients with carotid atherosclerosis found that Tongxinluo capsules combined with statins significantly decreas…
• Adds Chinese herbs to statins for better plaque reduction • Helps people with clogged neck arteries avoid strokes • Not yet approved outsi…
Pre-admission statin use linked to better 30-day outcomes after aneurysmal SAH
Pre-admission statin use linked to better 30-day outcomes in brain bleed patients
This observational study of 1,431 patients with aneurysmal subarachnoid hemorrhage found that pre-admission statin use was associated with a…
Using statins before a brain bleed may improve early recovery chances, but benefits did not last to 90 days in this real-world study.
Nurse-led care coordination fails to improve medication adherence in high-need patients
Nurse-led care coordination did not improve medication adherence for most common chronic conditions
This pragmatic randomized controlled trial tested nurse-led care coordination versus usual care in high-need, high-cost commercially insured…
A large trial found that nurse-led care coordination did not improve how often people took their diabetes, heart, or thyroid medications com…
High LDL-C to HDL-C ratio linked to cardiovascular events in type 2 diabetes with retinopathy
High cholesterol ratio raises heart risk in diabetics
This post hoc analysis of a randomized controlled trial in 5,006 high-risk type 2 diabetes patients with diabetic retinopathy found that a h…
A routine cholesterol test may reveal hidden heart danger in people with diabetes, even when taking cholesterol drugs.
Diabetes Prevalence and Clinical Correlates in Hospitalized Heart Failure Patients in China
Diabetes is common in hospitalized heart failure patients in China
This retrospective cohort study of 2,008 adults hospitalized with heart failure in China found a 23.21% prevalence of diabetes.
In a study of 2,008 hospitalized heart failure patients in China, 23.21% had diabetes, and certain factors like female sex and higher blood …
PCSK9 inhibitor initiation associated with lower depression risk versus statins in hyperlipidemia
Could lowering cholesterol with a new drug also protect against new episodes of depression?
A population-based cohort study of 35,610 adults with hyperlipidemia found PCSK9 inhibitor initiation was associated with lower risk of inci…
Starting a new cholesterol drug might lower the risk of developing depression compared to standard statins, based on data from over 35,000 a…
Meta-analysis finds no significant association between statin use and ALS survival outcomes
Do statins help people with ALS live longer? A new analysis finds no clear link
A meta-analysis of 3,739 ALS patients (889 statin users) from six studies found no statistically significant association between statin use …
A new analysis of 3,739 people with ALS found no link between taking statins and living longer.