Clinical Trial Search

Primary: Changes in the Breakfast Game Performance: Number of Tables Set Score — 1.61; 1.43 score on a scale (change)

Primary: Simple Reaction Time (Attention) — 287.7 ms

Primary: Depression_1 — 9.87; 10.24; 7.65; 9.15 score on a scale

Primary: Knowledge of Memory Aging Questionnaire-Revised — 19.8; 19.5 units on a scale

Primary: Change From Baseline in California Verbal Learning Task Score — 3.04; 5.17; 4.22; 7.04 score on a scale

Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items

Primary: Object Location Touchscreen Task (Version C) Free Recall Total Error — 121.498; 99.77 centimeters — p=.300

Primary: Change in Magnetoencephalography (MEG) Connectivity Measures

Primary: Working Memory — 0.86; 0.04 digits recalled

Primary: Total Number of Goals Improved to Criterion on the Canadian Occupational Performance Measure (COPM) — 50; 19.6; 50; 32.6 percentage of untrained goals improved — p=0.03

Primary: UCSD Performance-based Skills Assessment Total Score (Measures Functional Capacity) — 82.7; 84.4 units on a scale

Primary: Composite Score of Attention and Executive Functioning From a Neurocognitive Test Battery — 0.18; -0.06 units on a scale

Primary: Percentage of Trials Correct On Working Memory Test — 87.69; 91.57; 88.01; 91.68 percentage of correct trials — p=>0.05

Primary: Magnetic Resonance Spectroscopy (MRS) Will Measure a Change in Cerebral Energy Function in Brain Tissue — .011; .007; .009; .006 Difference in metabolite amplitude

Primary: Percentage of Recruited Subjects Able to Comply With the Protocol — 12; 13; 3; 14 Participants

Primary: California Verbal Learning Test-II (CLVT-II) — 55.84; 55.39 age adjusted t-scores

Primary: Acute Effect of a rTMS Session on the Performance for a Working Memory Task, as Measured by Accuracy (in Percentage) — 50.43; 55.42; 83.93; 46.49 percentage of accuracy

Primary: Complutense Verbal Learning Test (TAVEC) - Memory — 0.94; -0.81; 1.65; -0.31 units on a scale

Primary: Change in the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) — -0.89; 0.55 score

Primary: Change in Cognitive Function — 0.28; .65; 1.84; -.73 T score

Primary: Number of Remembered Items — 1.72; 1.68; 1.68; 1.65 remembered items — p=0.783

Primary: Retention in Study — 22; 21 Participants

Primary: Change From Baseline on a Composite Measure (Z-score) of Attention, Working Memory, and Executive Functions — 0.26; .01 Change to Z (composite) score

Primary: Cortical Excitability: Resting Motor Threshold (RMT). — 51.1; 51.8 % of Max Stimulation Output (MSO)

Primary: Change in Hippocampal-dependent Learning — -.00369; .00404 learning rate (proportion correct/trial) — p=<.05

Primary: Change in Prefrontal Cortex Brain Activity Assessed by fMRI — -0.002; 0.015 Percent BOLD Signal Change

Primary: Percent Change in Accuracy on High-control (i.e., Difficult) Condition of Preparing to Overcome Prepotency Task — 8.6; 9.2 percent change in accuracy

Primary: Change in Brain Nicotinamide Adenine Dinucleotide Metabolites NAD+/NADH — -0.79 ratio

Primary: System Usability Scale — 46.25; 10 score on a scale

Primary: Geriatric Depression Scale Change Score — .89; 0.50 score on a scale