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Home › Conditions › Aging

Aging

13 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Aging

153 trials tracked for Aging: 10 in phase 3 or 4 and 3 with published results. The most-cited published study has 106 citations.

153Trials tracked
10Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 5 Phase 3 5 Phase 2 19 Phase 1 9 Other / NA 115
  1. Phase 3 The LIFE Study - Lifestyle Interventions and Independence for Elders Completed · 106 cited
  2. Phase 4 Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults Completed · 11 cited
  3. Phase 4 Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines Completed · 4 cited
  4. Phase 4 Metformin in Longevity Study (MILES). Completed
  5. Phase 4 Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial Completed
  6. Phase 4 Changing in Skin Physiology After Microdroplet Placement of Stabilized Hyaluronic Acid in Aging Faces Completed
Show 44 more trials
  1. Phase 3 Cognition in the Study of Tamoxifen and Raloxifene Completed
  2. Phase 3 A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes Completed
  3. Phase 3 Subjects' Satisfaction on Pan Facial Aesthetic Enhancement After Treatment With Azzalure® and the Restylane® Range Completed
  4. Phase 3 ACTIVE: Advanced Cognitive Training for Independent and Vital Elderly Completed
  5. Phase 2 Semaglutide Use in Elderly Obese Patients Completed
  6. Phase 2 The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity Completed
  7. Phase 2 Nutraceutical Effects on Long-Term Memory Completed
  8. Phase 2 Resveratrol and Exercise to Treat Functional Limitations in Late Life Completed
  9. Phase 2 The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial Completed
  10. Phase 2 SGLT2 Inhibition in Older Obese Adults With Pre-diabetes Completed
  11. Phase 2 Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age Completed
  12. Phase 2 Acarbose Anti-aging Effects in Geriatric Subjects (Substudy B & C) Completed
  13. Phase 2 Effects of Testosterone Gel on Carbohydrate and Lipid Metabolism In Elderly Obese Men Completed
  14. Phase 2 Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease Completed
  15. Phase 2 Executive Functioning Training Study Completed
  16. Phase 2 Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly Completed
  17. Phase 2 Evaluation of the Mechanism of Action of Platelet Rich Fibrin Matrix (PRFM) in Producing Skin Volume Augmentation Completed
  18. Phase 2 Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease Completed
  19. Phase 2 Pilot Study of Losartan and N-acetylcysteine as Inhibitors of Muscle Oxidative Stress in Elderly Completed
  20. Phase 2 Efficacy of Polypodium Leucotomos Extract Decreasing UVA Premutagenic and Photoaging Markers Completed
  21. Phase 2 ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension Completed
  22. Phase 2 Postmenopausal Women Estrogen and Progesterone Infusion Completed
  23. Phase 2 Acute Effects of Cannabis on Cognition and Mobility in Older HIV-infected and HIV-Un-infected Women Completed
  24. Phase 1 Muscle Perfusion and Protein Metabolism in Elderly Completed
  25. Phase 1 Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study Completed
  26. Phase 1 Age Comparisons of Exercising Muscle O2 Supply in Healthy Adults: Effects of Esmolol Infusion Completed
  27. Phase 1 Spinal Excitation to Enhance Mobility Completed
  28. Phase 1 Topical-RAPA Use in Inflammation Reversal and Re-setting the Epigenetic Clock Completed
  29. Phase 1 Metformin to Augment Strength Training Effective Response in Seniors (MASTERS) Completed
  30. Phase 1 CONTROL Walking Study Completed
  31. Phase 1 Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals Completed
  32. Phase 1 A Trial of Habit Formation Theory for Exercise in Older Adults Completed
  33. N/A Everyday Memory Intervention Completed
  34. N/A Ambient Independence Measures for Guiding Care Transitions Completed
  35. N/A Oral Hygiene in Assisted Living Completed
  36. N/A PEU in Elderly TCU Residents Completed
  37. N/A SimpleC Wellness Platform With Social Robot Interaction Completed
  38. N/A ABSORB (Amount of Blueberries So Older Adults Reap Benefits) Completed
  39. N/A A Needs-focused Palliative Care Intervention for Older Adults in ICUs Completed
  40. N/A Psychosocial Intervention for Older HIV+ Adults With HAND Completed
  41. N/A Effects of Gamma-tACS on Memory and Sleep Completed
  42. N/A Cardio-vascular Protective Effects of Wolfberry in Middle-aged and Older Adults Completed
  43. N/A Exercise Effects on Word Learning Completed
  44. N/A Cardiovascular Responses to Heat Waves in the Elderly Completed

Showing the 50 most-cited and recently-updated of 153 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Aging: what the trials found

Physical activity has been shown to significantly reduce the incidence of major mobility disability, specifically defined as the incapacity to walk 400 meters, and is associated with lower rates of persistent mobility disability over a 6-month assessment period 14.

Restylane Vital was found to improve skin hydration, elasticity, and melanin index 13.

Cognitive training did not result in statistically significant changes in memory, reasoning, or speed of processing over a 10-year period 18.

Recent results — preliminary, needs further review

  • OneClick Social Engagement Intervention significantly improved scores for social isolation, loneliness, and quality of life in patients with Alzheimer's disease 7.
  • Yakult 300 LIGHT Fermented Milk was associated with significant changes in gut microbiota and improvements in sarcopenia markers (handgrip strength and walking speed) 5.
  • Daily mouth care significantly reduced the Plaque Index Score for Long-Term Care over a 4-month period 3.
  • Nitrate-containing interventions were associated with changes in carotid artery compliance and carotid pulse pressure 2.
  • Cannabis showed no statistically significant acute effects on mobility gait speed, balance (functional reach), or sustained attention 19.

For the clinician treating this condition

  • Physical activity is an established intervention to reduce major and persistent mobility disabilities in aging populations 14.
  • Social engagement interventions have shown significant improvements in loneliness and quality of life for patients with Alzheimer's disease 7.
  • Fermented milk (Yakult 300 LIGHT) may impact gut microbiota and improve physical markers associated with sarcopenia 5.

AI synthesis of 8 cited trials, updated Jun 25, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic review examines nine therapeutic peptides for targeting aging hallmarks in older adults
Geriatrics & Aging Sys. Review
Systematic review examines nine therapeutic peptides for targeting aging hallmarks in older adults Can peptides help us age better? A review looks at nine promising compounds
A systematic review of 20 primary sources examined nine therapeutic peptides for healthy aging and age-related conditions in aging populatio…
Nine therapeutic peptides target aging biology, from restoring metabolism to protecting the brain, though experts warn more research is need…
Frontiers Apr 8, 2026

Questions about Aging

Do antioxidant strategies help male infertility in aging men with immune disorders?

Antioxidant strategies may help male infertility in aging men with immune disorders by reducing oxidative stress, but evidence is preliminary and personalized approaches are needed.

Full answer →