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Home › Conditions › Allergic Rhinitis

Allergic Rhinitis

Subtypes of Allergic Rhinitis

Hay Fever 2 House dust mite allergy 1 Seasonal allergic rhinitis 1

25 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Allergic Rhinitis

73 trials tracked for Allergic Rhinitis: 40 in phase 3 or 4 and 4 with published results. The most-cited published study has 206 citations.

73Trials tracked
40Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 17 Phase 3 23 Phase 2 13 Phase 1 6 Other / NA 14
  1. Phase 3 Safety and Efficacy Study of Sublingual Immunotherapy (SLIT) to Treat House Dust Mite Allergic Rhinitis Completed · 206 cited
  2. Phase 4 Safety Study of Levocetirizine and Fexofenadine Completed · 20 cited
  3. Phase 4 A Study to Compare the Efficacy and Safety of Fluticasone Furoate Nasal Sprays (FFNS) 55 Microgram (mcg) and 110 mcg in Chinese Pediatric Subjects With Allergic Rhinitis (AR) Completed · 16 cited
  4. Phase 4 Comparison Between Systemic Exposure to Ciclesonide Nasal Spray, Ciclesonide HFA Nasal Aerosol and Orally Inhaled Ciclesonide (BY9010/M1-422) Completed · 15 cited
  5. Phase 4 Effects of Bilastine on F1 Simulator Driving Performance in Patients Affected by Allergic Rhinitis and/or Urticaria Completed
  6. Phase 4 Comparability and Standardization of Controlled Allergen Challenge Facilities Completed
Show 44 more trials
  1. Phase 4 Sunovion Growth Study Pediatric Subjects With Mild Asthma & Allergic Rhinitis Completed
  2. Phase 4 A Study to Evaluate Cooling Sensation of an Allergy Product in Adults With a History of Allergies Completed
  3. Phase 4 An Allergen BioCube (ABC) Study Evaluating the Efficacy of Fluticasone Propionate Nasal Spray Compared to Placebo Completed
  4. Phase 4 Immunologic Basis of Anti-IgE Therapy (Study II: On Patients With Asthma) Completed
  5. Phase 4 Factors Involved in Dymista's Superior Clinical Efficacy in the Treatment of Seasonal Allergic Rhinitis Completed
  6. Phase 4 Safety of Astepro 0.15% Nasal Spray and Astepro 0.1% Nasal Spray in Children Ages >6 Months to <6 Years With AR Completed
  7. Phase 4 Effect of Veramyst on the Nasal and Ocular Symptoms of the Early Reaction to Nasal Challenge With Allergen Completed
  8. Phase 4 Intranasal Steroids and Oxymetazoline in Allergic Rhinitis Completed
  9. Phase 4 Is Levocetirizine Less Sedating Than Cetirizine? Completed
  10. Phase 4 Evaluation of the Sensory Attributes of Olopatadine 0.6% and Azelastine 137mcg Nasal Sprays in Patients w/Allergic Rhinitis Completed
  11. Phase 4 Montelukast in Mild Asthmatic Children With Allergic Rhinitis (0476-367) Completed
  12. Phase 4 A Randomised, Double Blind, Placebo Controlled, 4 Period, Incomplete Block, Crossover Study Assessing the Dose-response Curve of Fluticasone Propionate in an Antigen Challenge Chamber Completed
  13. Phase 3 Efficacy and Safety Trial of Pangramin SLIT HDM-mix in Subjects With House Dust Mite Induced Rhinitis Completed
  14. Phase 3 Safety and Efficacy of Mometasone Furoate Nasal Spray With the Addition of Loratadine Versus Placebo in Participants With Seasonal Allergic Rhinitis (C94-145) Completed
  15. Phase 3 Study to Assess the Efficacy of Anti-Bet v 1 Monoclonal Antibodies in Adults to Reduce Symptoms of Seasonal Allergic Rhinitis Completed
  16. Phase 3 Adolescent Mite Allergy Safety Evaluation Completed
  17. Phase 3 An Exploratory Study of Nasonex in Patients With Moderate to Severe Persistent Allergic Rhinitis and Intermittent Asthma Completed
  18. Phase 3 Efficacy and Long-Term Safety of Ragweed (Ambrosia Artemisiifolia) Sublingual Tablet (SCH 39641) in Adults With a History of Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (Study P05234) Completed
  19. Phase 3 A 6 Month Safety and Efficacy Study of Once Daily Ciclesonide Hydrofluoroalkane (HFA) in the Treatment of Perennial Allergic Rhinitis (PAR) in Subjects 12 Years and Older Completed
  20. Phase 3 3 Month Safety Study of Dymista Nasal Spray and Fluticasone Propionate in Children 4-11 Years of Age With Allergic Rhinitis Completed
  21. Phase 3 Safety Study of Levocetirizine Dihydrochloride Oral Liquid Formulation in Children Aged 1 to Less Than 6 Years Suffering From Allergic Rhinitis or Chronic Urticaria of Unknown Origin Completed
  22. Phase 3 Topical ASP-1001 (Contrast Media Formulation) and the Acute Response to Nasal Allergen Challenge (NAC) Completed
  23. Phase 3 Hypothalamic-Pituitary-Adrenal (HPA)-Axis Study in Pediatric Subjects With Perennial Allergic Rhinitis (PAR) Completed
  24. Phase 3 Study of Nasonex in the Relief of Nasal Congestion in Patients With Seasonal Allergic Rhinitis (Study P05528)(COMPLETED) Completed
  25. Phase 3 Safety Study of Levocetirizine Dihydrochloride Oral Liquid Formulation in Children Aged 6 Months to 11 Months Completed
  26. Phase 3 Study of Nasonex in the Relief of Nasal Congestion in Patients With Seasonal Allergic Rhinitis (Study P05529) Completed
  27. Phase 3 Assessment of Fluticasone Propionate on Ocular Allergy Symptoms Completed
  28. Phase 3 A Study to Evaluate the Safety of Combination Montelukast/Loratadine in Mexican Participants With Allergic Rhinitis (MK-0476A-484) Completed
  29. Phase 3 A Study of SCH 697243 in Participants With Grass Pollen Allergy Symptoms, With or Without Asthma (P08067) Completed
  30. Phase 3 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Fluticasone Furoate Nasal Spray for 2 Weeks in Chinese Adult and Adolescent Subjects With Allergic Rhinitis Completed
  31. Phase 3 Efficacy Study of Sublingual Immunotherapy to Treat Ragweed Allergies Completed
  32. Phase 3 Study for the Treatment of Persistent Allergic Rhinitis With Desloratadine (Study P04684) Completed
  33. Phase 3 Study of an Investigational Nasal Aerosol or Placebo in Children (Ages 4 to 11) With Perennial Allergic Rhinitis (PAR) Completed
  34. Phase 3 Study of Nasonex in the Relief of Nasal Congestion in Patients With Seasonal Allergic Rhinitis (Study P05583) Completed
  35. Phase 2 Grass Pollen Allergen Immunotherapy Tablet (AIT) Time Course Study Completed
  36. Phase 2 Efficacy of the Anti-Bet v 1 Monoclonal Antibodies (Given Subcutaneously) to Reduce Allergic Rhinitis and Conjunctivitis Symptoms and Skin Test Reactivity Upon Exposure to Birch Allergen in Adult Participants Completed
  37. Phase 2 Dupilumab As An Adjunct For Subcutaneous Grass Immunotherapy Completed
  38. Phase 2 Efficacy Study in Allergic Rhinitis Patients After Intranasal Administration of AZD8848 Completed
  39. Phase 2 Clinical Response to Rhinovirus Challenge Completed
  40. Phase 2 A Novel Biologic Therapy for Perennial Allergic Rhinitis Completed
  41. Phase 2 Efficacy Study of a Preseasonal Treatment With AllerT in Subjects With Birch Pollen Allergy Completed
  42. Phase 2 Effects of Broccoli Sprout Extract on Allergy Rhinitis Completed
  43. Phase 2 Efficacy and Safety of SUBLIVAC Phleum for Immunotherapy of Grass Pollen-Allergy Completed
  44. Phase 2 Safety and Pharmacokinetics of Patanase in Pediatric Patients 2 to < 6 Years of Age Completed

Showing the 50 most-cited and recently-updated of 73 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Peri- and postmenopausal hormonal changes may exacerbate asthma, rhinitis, cough, allergies, hypersensitivity, anaphylaxis, and angioedema
Allergy & Immunology Sys. Review
Peri- and postmenopausal hormonal changes may exacerbate asthma, rhinitis, cough, allergies, hypersensitivity, anaphylaxis, and angioedema Menopause Changes Allergy Rules for Women
This systematic review examines the association between declining and fluctuating estrogen and progesterone levels and various allergic and …
Menopause can worsen allergies like hay fever and asthma because dropping estrogen levels make your immune system more reactive to triggers.
Frontiers Apr 14, 2026
A single case report confirms rare IgE-mediated cocoa allergy causing anaphylaxis in a child
Pediatrics Sys. Review
A single case report confirms rare IgE-mediated cocoa allergy causing anaphylaxis in a child Your Child's Chocolate Reaction Might Not Be Milk or Nuts
This systematic review and case report describes a 2-year-old female with a history of allergic rhinitis and tree nut anaphylaxis who experi…
Most chocolate reactions aren't the cocoa itself, but a rare toddler case proves true cocoa allergies exist and require careful testing to f…
Frontiers Apr 14, 2026
Serum 25-hydroxyvitamin D levels associated with disease severity in children with allergic rhinitis and adenoid hypertrophy
Nutrition & Obesity Medicine Cohort
Serum 25-hydroxyvitamin D levels associated with disease severity in children with allergic rhinitis and adenoid hypertrophy Low Vitamin D May Worsen Your Child's Allergies and Sleep
This retrospective observational study examined 268 children aged 3 to 12 years with co-existing allergic rhinitis and adenoid hypertrophy.
A simple blood test might reveal a surprising factor behind a child's constant congestion and restless nights.
Frontiers Apr 13, 2026
Meta-analysis of mercury exposure in children associates with higher prevalence of asthma, atopic dermatitis, and other allergic outcomes
Pediatrics Meta-analysis
Meta-analysis of mercury exposure in children associates with higher prevalence of asthma, atopic dermatitis, and other allergic outcomes A Hidden Link in Your Child's Allergies Might Be in Your Diet
This systematic review and meta-analysis examined sixteen studies involving children with measured mercury exposure in East Asia and Europe.
Mercury exposure in early life is linked to asthma, eczema, and other allergies in children, with up to 22% of exposed kids affected.
Frontiers Apr 10, 2026
House dust mite immunotherapy reduces IgE and symptoms in Indonesian children with allergic rhinitis and asthma
Allergy & Immunology RCT
House dust mite immunotherapy reduces IgE and symptoms in Indonesian children with allergic rhinitis and asthma Could weekly dust mite shots help Indonesian children breathe easier with less medicine?
A small RCT of 41 Indonesian children with allergic rhinitis and asthma found 14 weeks of weekly subcutaneous HDM immunotherapy significantl…
Weekly dust mite shots helped Indonesian children with allergies and asthma breathe easier, needing fewer pills and feeling less discomfort …
Apr 9, 2026
Stapokibart shows nasal symptom reduction in pediatric seasonal allergic rhinitis case series
Allergy & Immunology Cohort
Stapokibart shows nasal symptom reduction in pediatric seasonal allergic rhinitis case series Could a new drug help teens breathe easier during allergy season?
A retrospective case series of 20 pediatric patients with moderate-to-severe seasonal allergic rhinitis found that all patients demonstrated…
Twenty young patients with moderate-to-severe seasonal allergic rhinitis took stapokibart for one month.
Frontiers Apr 9, 2026
Acupuncture plus sphenopalatine ganglion needling shows higher response rate than loratadine for allergic rhinitis
Allergy & Immunology RCT
Acupuncture plus sphenopalatine ganglion needling shows higher response rate than loratadine for allergic rhinitis Acupuncture combined with targeted needling may improve allergy symptoms better than standard medication
A 260-patient RCT in persistent moderate-to-severe allergic rhinitis found combination acupuncture and sphenopalatine ganglion needling had …
Combining acupuncture with targeted needling helped more hay fever patients find relief than standard allergy medication alone.
Apr 8, 2026
Parental autoimmune diseases associated with increased risk of asthma, eczema in offspring
Allergy & Immunology Meta-analysis
Parental autoimmune diseases associated with increased risk of asthma, eczema in offspring Parental autoimmune diseases linked to higher allergy risk in children
A systematic review and meta-analysis of 12 studies found maternal autoimmune diseases were associated with increased odds of asthma (OR 1.2…
Children of parents with autoimmune diseases face higher risks for asthma, eczema, and hay fever, according to a new analysis of existing he…
Apr 3, 2026
Meta-analysis finds allergic rhinitis associated with 2.75-fold increased migraine risk
Rheumatology Meta-analysis
Meta-analysis finds allergic rhinitis associated with 2.75-fold increased migraine risk Do allergies make migraines more likely? A new review finds a strong link
A systematic review and meta-analysis of 10 observational studies involving over 4.8 million participants found allergic rhinitis was signif…
Millions with seasonal allergies may also face a higher risk of migraines, according to new research analyzing data from over 4.8 million pe…
Frontiers Apr 2, 2026
Gut microbiome interventions show conceptual promise for allergic rhinitis but clinical application remains constrained
Allergy & Immunology Sys. Review
Gut microbiome interventions show conceptual promise for allergic rhinitis but clinical application remains constrained Can fixing your gut help with seasonal allergies? The science isn't ready yet
A narrative mini-review examining gut microbiome-based interventions for allergic rhinitis found these therapies represent a promising conce…
Gut microbiome therapies for seasonal allergies show promise, but doctors lack standard tests to measure results or confirm long-term safety…
Frontiers Apr 2, 2026
Dietary zinc supplementation alleviates allergic rhinitis in rats via gut-nasal axis
Allergy & Immunology
Dietary zinc supplementation alleviates allergic rhinitis in rats via gut-nasal axis Could zinc help with allergies? A rat study suggests a possible gut-nose connection
A preclinical animal study in rats found dietary zinc supplementation may alleviate allergic rhinitis, especially at 150 ppm, through mechan…
A rat study suggests zinc supplements might help seasonal allergies by balancing gut bacteria and reducing inflammation in the nose.
Frontiers Apr 1, 2026
FDA Approves Children's Zyrtec Allergy (cetirizine) for Symptoms of Upper Respiratory Allergies
Allergy & Immunology FDA Approval
FDA Approves Children's Zyrtec Allergy (cetirizine) for Symptoms of Upper Respiratory Allergies FDA approves a chewable allergy medicine for children called Children's Zyrtec Allergy
The FDA approved Children's Zyrtec Allergy (cetirizine) for temporarily relieving symptoms of hay fever or other upper respiratory allergies…
FDA approves chewable allergy medicine for kids as young as 2 to help with runny nose, sneezing, and itchy eyes from hay fever.
FDA Mar 31, 2026

Questions about Allergic Rhinitis

Do hormonal changes during menopause make allergic rhinitis symptoms worse?

Yes, hormonal changes during menopause may worsen allergic rhinitis symptoms by affecting immune and nasal tissue responses, though evidence is limited.

Full answer →
How do environmental exposures and microbiome changes affect allergic rhinitis?

Environmental exposures like air pollution and climate change disrupt the nasal microbiome and epithelial barrier, increasing allergic rhinitis risk, while microbial changes (dysbiosis) promote inflammation.

Full answer →
Can swimming pool attendance increase the risk of allergic rhinitis in children?

Current evidence does not show that swimming pool attendance increases the risk of allergic rhinitis in children; some studies even suggest a protective effect.

Full answer →