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Home › Conditions › seasonal allergic rhinitis

Seasonal allergic rhinitis

Part of Allergic Rhinitis

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for seasonal allergic rhinitis

81 trials tracked for seasonal allergic rhinitis: 62 in phase 3 or 4 and 4 with published results. The most-cited published study has 56 citations.

81Trials tracked
62Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 16 Phase 3 46 Phase 2 11 Phase 1 2 Other / NA 6
  1. Phase 3 Efficacy and Safety Study of RAGWITEK™ (MK-3641) in Children With Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (MK-3641-008) Completed · 56 cited
  2. Phase 3 Efficacy and Safety of Fixed Dose Combination GSP 301 Nasal Spray (NS) in the Treatment of Seasonal Allergic Rhinitis (SAR) Completed · 44 cited
  3. Phase 3 An Exploratory Study of PQ Grass 27600 SU Completed · 2 cited
  4. Phase 3 Efficacy and Safety of PQ Grass in Subjects With Seasonal Allergic Rhinitis and/or Rhinoconjunctivitis Induced by Grass Pollen Completed · 2 cited
  5. Phase 4 Fluticasone Furoate Nasal Spray Versus Oral Fexofenadine Completed
  6. Phase 4 Fluticasone Furoate Treatment of Daytime Somnolence and Cognitive Performance in Seasonal Allergic Rhinitis Completed
Show 44 more trials
  1. Phase 4 Compare the Efficacy of Levocetirizine and Montelukast to Placebo in Reducing Seasonal Allergic Rhinitis (SAR) Symptoms in Ragweed Sensitive Subjects Completed
  2. Phase 4 Nasonex Compared With Placebo in Participants With Seasonal Allergic Rhinitis (SAR) and Concomitant Asthma (P03280) Completed
  3. Phase 4 Allergic Rhinitis Changes the Sinus Microbiome Completed
  4. Phase 4 Dymista Allergen Chamber - Onset of Action Study Completed
  5. Phase 4 Comparison of Olopatadine 0.6% and Fluticasone Proprionate 50mcg Nasal Sprays in a Two Week Seasonal Allergic Rhinitis Trial Completed
  6. Phase 4 Comparison of Seasonal Allergic Rhinitis Treatment With 2 Antihistamines Used in Combination With Intranasal Corticosteroid Completed
  7. Phase 4 A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis Completed
  8. Phase 4 Vitamin D Plus Fluticasone Propionate Completed
  9. Phase 4 Effect of Veramyst and Olopatadine 0.2% Opthalmic Solution on Allergy Symptoms Completed
  10. Phase 4 Fluticasone Furoate Nasal Spray Versus Oral Fexofenadine Completed
  11. Phase 4 Mometasone Furoate on Sleep Disturbances in Subjects With Seasonal Allergic Rhinitis (Study P04608) (COMPLETED) Completed
  12. Phase 4 Safety Study of MK-3641 and MK-7243 Co-administered in Adult Participants With Ragweed and Grass Pollen Induced Allergic Rhinitis (P08607, MK-3641-006) Completed
  13. Phase 4 This Study Contains an Active Drug Treatment Group With Mometasone Furoate Nasal Spray and a Placebo (Dummy) Treatment Group for Seasonal Allergic Rhinitis (SAR). (Study P05073)(COMPLETED) Completed
  14. Phase 4 A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis Completed
  15. Phase 3 Efficacy and Safety Study of Desloratadine (MK-4117) in Japanese Participants With Seasonal Allergic Rhinitis (MK-4117-204) Completed
  16. Phase 3 Efficacy and Safety of Ciclesonide Nasal Spray in Participants With Seasonal Allergic Rhinitis (SAR) in Russia Completed
  17. Phase 3 Safety and Efficacy of Mometasone Furoate (SCH 032088) vs Beclomethasone Dipropionate or Placebo in Seasonal Allergic Rhinitis (C93-013) Completed
  18. Phase 3 Dose-Ranging Study of Mometasone Furoate (MK-0887/SCH 032088) Nasal Spray in the Treatment of Children (Ages 6-11) With Seasonal Allergic Rhinitis (C95-161) Completed
  19. Phase 3 Mometasone Furoate Aqueous (MK-0887/SCH 032088) Nasal Spray vs Placebo and FLONASE® in Seasonal Allergic Rhinitis Patients (I94-001) Completed
  20. Phase 3 Onset of Action of Mometasone Furoate (MK-0887/SCH 032088) Nasal Spray Compared With Placebo in Seasonal Allergic Rhinitis (C93-184) Completed
  21. Phase 3 Study of Efficacy and Safety of Omalizumab in Severe Japanese Cedar Pollinosis Adult and Adolescent Patients Completed
  22. Phase 3 Clinical Equivalence Study of Mometasone Nasal Spray Completed
  23. Phase 3 A Study Comparing the Clinical Equivalence of Two Mometasone Nasal Sprays in the Relief of the Signs and Symptoms of Seasonal Allergic Rhinitis Completed
  24. Phase 3 A Study Comparing Two Fluticasone Furoate Nasal Sprays in the Relief of the Signs and Symptoms of Seasonal Allergic Rhinitis Completed
  25. Phase 3 Comparative Safety and Efficacy of Two Steroid Treatments in the Relief of the Symptoms of Seasonal Allergic Rhinitis Completed
  26. Phase 3 A Placebo-controlled Study of 2-day Pre-treatment With Fexofenadine in Seasonal Allergic Rhinitis Completed
  27. Phase 3 A Study Investigating the Effect of Montelukast in Patients With Seasonal Allergic Rhinitis (MK-0476-192)(COMPLETED) Completed
  28. Phase 3 A Safety and Efficacy Study of Ciclesonide Nasal Aerosol in Subjects 6-11 Years With Seasonal Allergic Rhinitis (SAR) Completed
  29. Phase 3 Placebo-Controlled Study of Mometasone Furoate Nasal Spray (MFNS) 200 mcg QD in the Treatment of Seasonal Allergic Rhinitis (Study P05106)(COMPLETED) Completed
  30. Phase 3 Safety and Efficacy Trial of Dymista Nasal Spray in Children Ages 4 to 11 With Seasonal Allergic Rhinitis (SAR) Completed
  31. Phase 3 A Study Comparing Montelukast With Placebo in Children With Seasonal Allergic Rhinitis (0476-219)(COMPLETED) Completed
  32. Phase 3 Study in Adult and Adolescent Subjects With Seasonal Allergic Rhinitis (SAR) Completed
  33. Phase 3 A Study to Evaluate the Safety and Effectiveness of a Nasal Spray to Treat Seasonal Allergies Completed
  34. Phase 3 A Study to Evaluate the Safety and Effectiveness of a Nasal Spray to Treat Seasonal Allergies Completed
  35. Phase 3 The Effects of Phenylephrine Compared With Those of Placebo and Pseudoephedrine on Nasal Congestion in Subjects With Seasonal Allergic Rhinitis (SAR)(P04579) Completed
  36. Phase 3 Consumer Preference Study of Two Formulations of Phenylephrine Hydrochloride (Study CL2008-15)(P07530)(COMPLETED) Completed
  37. Phase 3 A Study to Evaluate the Safety & Effectiveness of a Nasal Spray to Treat Seasonal Allergies Completed
  38. Phase 3 Safety and Efficacy of Olopatadine HCl Nasal Spray in 6-11 Year Old Patients Completed
  39. Phase 3 Study of the Efficacy and Safety of MK-0476 in Japanese Pediatric Participants With Seasonal Allergic Rhinitis (MK-0476-519) Completed
  40. Phase 3 Clinical Trial to Assess the Efficacy and Safety of Ciclesonide Hydrofluoroalkane (HFA) Nasal Aerosol for the Treatment of Seasonal Allergic Rhinitis (SAR) to Mountain Cedar in Subjects 12 Years and Older Completed
  41. Phase 3 Study of an Investigational Nasal Aerosol or Placebo Nasal Aerosol in Children (Ages 6-11) With Seasonal Allergies Completed
  42. Phase 3 Assessment of Fluticasone Propionate on Ocular Allergy Symptoms Completed
  43. Phase 3 Clinical Trial to Assess the Efficacy and Safety of Ciclesonide Hydrofluoroalkane (HFA) Nasal Aerosol for the Treatment of Seasonal Allergic Rhinitis Completed
  44. Phase 3 A Study to Evaluate the Safety and Effectiveness of a Nasal Spray to Treat Seasonal Allergies Completed

Showing the 50 most-cited and recently-updated of 81 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Seasonal allergic rhinitis: what the trials found

For seasonal allergic rhinitis, several treatments have demonstrated efficacy. A fixed combination of azelastine hydrochloride and fluticasone propionate nasal spray (Dymista) significantly improved total nasal symptom scores (TNSS) and total ocular symptom scores (TOSS) compared to placebo 2. Similarly, another azelastine/fluticasone combination showed significant improvements in reflective and instantaneous TNSS 22. Fluticasone furoate combined with fexofenadine significantly reduced nighttime symptom scores and reflective total nasal symptom scores 717. Olopatadine HCl nasal spray (0.6%) improved reflective and instantaneous TNSS and reflective TOSS 1114. Levocetirizine dihydrochloride significantly reduced the 24-hour reflective total 5 symptoms score and improved rhinoconjunctivitis quality of life in one trial 15, but another trial showed no significant difference 16, indicating mixed evidence. Mometasone furoate nasal spray did not show significant improvement in TNSS at 6 hours post-dose 12 or in total asthma symptom severity 4, but did significantly improve cough symptom scores 4. QNASL did not significantly improve TNSS or RQLQ scores 3. Vitamin D3 supplementation significantly improved daytime nasal symptom scores but not total nasal symptom scores 9. PL nasal spray significantly improved total eye symptoms, total nasal symptoms, and sneezing 10.

Allergen immunotherapy also shows benefit. PQ Grass significantly improved the combined symptom and medication score (CSMS) during peak grass pollen season in two trials 120. Short ragweed pollen allergen extract significantly improved total combined score and rhinoconjunctivitis daily symptom score during peak ragweed season 18. However, MK-3641 (short ragweed extract) was associated with local swelling and application site reactions, leading to discontinuation in some participants 8. Fexofenadine alone was evaluated but only reported adverse events without efficacy outcomes 21. Placebo was used as a comparator in some trials 5.

Recent results — preliminary, needs further review

  • PQ Grass (a grass pollen allergen extract) showed significant improvement in CSMS during peak grass pollen season in two phase 3 trials 120, but one trial also reported non-significant results for CSMS averaged over the entire season 1.
  • Azelastine hydrochloride/fluticasone propionate nasal spray demonstrated significant improvements in TNSS and iTNSS 22.
  • Fluticasone furoate combined with fexofenadine significantly improved nighttime and daytime nasal symptom scores 717.
  • Levocetirizine dihydrochloride showed conflicting results: one trial found significant improvement in symptoms and quality of life 15, while another did not 16.
  • Vitamin D3 supplementation significantly improved daytime nasal symptom scores but not total nasal symptom scores 9.

For the clinician treating this condition

  • Intranasal corticosteroids combined with antihistamines (e.g., azelastine/fluticasone) are effective for nasal and ocular symptoms in seasonal allergic rhinitis.
  • Allergen immunotherapy (e.g., PQ Grass, short ragweed extract) can reduce symptom and medication scores but may cause local reactions.
  • Levocetirizine shows inconsistent efficacy; consider alternative antihistamines if response is inadequate.
  • Vitamin D3 may improve daytime nasal symptoms but not overall nasal symptom scores.

AI synthesis of 19 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Stapokibart shows nasal symptom reduction in pediatric seasonal allergic rhinitis case series
Allergy & Immunology Cohort
Stapokibart shows nasal symptom reduction in pediatric seasonal allergic rhinitis case series Could a new drug help teens breathe easier during allergy season?
A retrospective case series of 20 pediatric patients with moderate-to-severe seasonal allergic rhinitis found that all patients demonstrated…
Twenty young patients with moderate-to-severe seasonal allergic rhinitis took stapokibart for one month.
Frontiers Apr 9, 2026

Research across Allergic Rhinitis

Related studies from across the Allergic Rhinitis family.

The nose-brain axis facilitates bidirectional inflammatory signaling and neuroinflammation in allergic rhinitis
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The nose-brain axis facilitates bidirectional inflammatory signaling and neuroinflammation in allergic rhinitis The Nose-Brain Axis Links Inflammation to Allergic Rhinitis Symptoms
This systematic review explores the role of the nose-brain axis in allergic rhinitis, focusing on mechanisms of central sensitization and ne…
New research explores how the nose-brain axis links nasal inflammation to central nervous system changes in people with allergic rhinitis.
Frontiers Oct 6, 2026
Functionalized mesenchymal stem cells and exosomes show potential for anti-inflammatory effects in allergic rhinitis
Oncology Sys. Review
Functionalized mesenchymal stem cells and exosomes show potential for anti-inflammatory effects in allergic rhinitis Stem Cells and Exosomes May Help Treat Allergic Rhinitis
This systematic review examines the efficacy of functionalized stem cells and their derivatives, such as exosomes, for managing allergic rhi…
New research explores how stem cells and their derivatives could offer a non-hormonal way to treat allergic rhinitis symptoms and inflammati…
Frontiers Sep 30, 2026
Biological heterogeneity and overlapping phenotypes complicate the classification of allergic rhinitis cases
Allergy & Immunology Sys. Review
Biological heterogeneity and overlapping phenotypes complicate the classification of allergic rhinitis cases New research shows allergic rhinitis is more complex than once thought
This narrative review explores the complex biological heterogeneity of the nasal mucosa in allergic rhinitis. It argues that overlapping fea…
Allergic rhinitis is not a single condition. New research shows a complex mix of cells and overlapping symptoms that can make treatment diff…
Frontiers Sep 23, 2026
Nasal tissue-resident memory T cells may provide a framework for understanding allergic rhinitis relapse
Allergy & Immunology Sys. Review
Nasal tissue-resident memory T cells may provide a framework for understanding allergic rhinitis relapse New cellular targets could help manage chronic allergy symptoms
This mini review explores the role of nasal tissue-resident memory (TRM) cells in allergic rhinitis and chronic rhinosinusitis with nasal po…
Scientists are looking at specific immune cells in the nose that might explain why some people's allergies keep coming back.
Frontiers Sep 18, 2026
Macrophage metabolic reprogramming and polarization may offer therapeutic targets for chronic airway inflammatory diseases
Dermatology Sys. Review
Macrophage metabolic reprogramming and polarization may offer therapeutic targets for chronic airway inflammatory diseases Metabolic Reprogramming May Offer New Path for Airway Inflammation
This systematic review examines the role of macrophage polarization and metabolic reprogramming in chronic upper and lower airway inflammato…
New research suggests that changing how certain immune cells process energy could offer a way to treat asthma and chronic sinus infections.
Frontiers Sep 8, 2026
Several risk factors including early-life antibiotic use and maternal OCP exposure increase allergic rhinitis risk
Allergy & Immunology Meta-analysis
Several risk factors including early-life antibiotic use and maternal OCP exposure increase allergic rhinitis risk Several Risk Factors Linked to Children with Allergic Rhinitis
This umbrella review of systematic reviews and meta-analyses synthesizes evidence regarding 75 risk factors for pediatric allergic rhinitis.…
New research identifies various factors, like early-life antibiotic use and air pollution, that are linked to a higher risk of allergic rhin…
Frontiers Sep 7, 2026
Comprehensive-component subcutaneous immunotherapy shows the most favorable symptom score reduction in allergic rhinitis
Allergy & Immunology Meta-analysis
Comprehensive-component subcutaneous immunotherapy shows the most favorable symptom score reduction in allergic rhinitis Comprehensive Immunotherapy Shows Best Results for Allergic Rhinitis Symptoms
This network meta-analysis of 7,329 participants evaluated three types of house dust mite allergen immunotherapy for allergic rhinitis. CC-S…
A large review of over 7,000 patients suggests that comprehensive subcutaneous immunotherapy may offer the strongest relief for allergic rhi…
Frontiers Sep 4, 2026
Press-needle therapy as an adjunct to medication improves clinical efficacy in pediatric allergic rhinitis
Allergy & Immunology Meta-analysis
Press-needle therapy as an adjunct to medication improves clinical efficacy in pediatric allergic rhinitis Press-needle therapy may improve symptoms for children with allergic rhinitis
This meta-analysis of 1625 children found that press-needle therapy combined with medication significantly improved clinical efficacy (OR 3.…
Adding press-needle therapy to medication may help children with allergic rhinitis experience fewer symptoms and a lower rate of recurrence.
Sep 1, 2026
Nasal saline irrigation significantly reduces nasal symptoms and rescue antihistamine use in pediatric allergic rhinitis
Allergy & Immunology Meta-analysis
Nasal saline irrigation significantly reduces nasal symptoms and rescue antihistamine use in pediatric allergic rhinitis Nasal Saline Irrigation Reduces Symptoms for Children with Allergies
This meta-analysis of 462 children and adolescents with allergic rhinitis found that nasal saline irrigation leads to a large reduction in n…
Nasal saline irrigation can significantly reduce nasal symptoms and the need for rescue antihistamines in children with allergic rhinitis.
Sep 1, 2026
Air pollution exposure increases type 2 inflammation-related markers and reduces ZO-1 in rodent models
Drug Pipeline Meta-analysis
Air pollution exposure increases type 2 inflammation-related markers and reduces ZO-1 in rodent models Air Pollution Worsens Allergic Rhinitis in Rodent Studies
This meta-analysis of 18 rodent studies indicates that air pollution exposure leads to increased eosinophils, IL-4, IL-5, IL-13, and OVA-spe…
Air pollution exposure boosts allergy inflammation in rodents, suggesting a link to worse allergic rhinitis in people.
Frontiers Aug 23, 2026
Framework Maps Skin-Nose Link in Pediatric Allergy
Allergy & Immunology Guideline
Framework Maps Skin-Nose Link in Pediatric Allergy New framework links eczema and allergic rhinitis in children
A new research framework explores how atopic dermatitis and allergic rhinitis may interact in children, guiding future studies.
A new research framework may explain why eczema and allergic rhinitis often occur together in children, but evidence is limited.
Frontiers Aug 7, 2026
Calcium homeostasis dysregulation serves as an integrative regulatory node in allergic rhinitis inflammation
Allergy & Immunology Sys. Review
Calcium homeostasis dysregulation serves as an integrative regulatory node in allergic rhinitis inflammation Calcium Imbalance May Drive Inflammation in Allergic Rhinitis
This systematic review explores the role of calcium signaling in allergic rhinitis pathogenesis, including mucosal barrier maintenance and i…
New research suggests that how your body manages calcium levels may play a key role in maintaining nasal barriers and driving allergic rhini…
Frontiers Jul 28, 2026