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Home › Conditions › Back Pain

Back Pain

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Back Pain

56 trials tracked for Back Pain: 17 in phase 3 or 4 and 3 with published results. The most-cited published study has 144 citations.

56Trials tracked
17Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 10 Phase 3 7 Phase 2 5 Other / NA 34
  1. Phase 4 Spinal Cord Stimulation for Predominant Low Back Pain Completed · 144 cited
  2. Phase 4 Duloxetine Treatment of Major Depression and Chronic Low Back Pain For Older Adults Completed · 34 cited
  3. Phase 4 ADAPT: Addressing Depression and Pain Together Completed · 32 cited
  4. Phase 4 Spinal Cord Stimulation (SCS) Dosing Study Completed
  5. Phase 4 Low Dose Ketamine (LDK) Versus Morphine for Acute Pain Control in the Emergency Department Completed
  6. Phase 4 Embrace TDD: Post-Market Study to Evaluate Intrathecal Morphine as an Alternative to Systemic Opioids for Chronic Pain Completed
Show 44 more trials
  1. Phase 4 Tapentadol Prolonged Release (PR) Versus Oxycodone/Naloxone Prolonged Release in Severe Chronic Low Back Pain With a Neuropathic Component. Completed
  2. Phase 4 Effect of Pulse Width With Spinal Cord Stimulation Completed
  3. Phase 4 A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to Osteoarthritis Completed
  4. Phase 4 Herniectomy Versus Herniectomy With a Spinal Stabilization System for the Treatment of Complex Disc Disease Completed
  5. Phase 3 Cyclobenzaprine HCl Extended Release 15 mg Versus Placebo in Treatment of Cervical and/or Lower Back Pain Due to Muscle Spasms of Local Origin Completed
  6. Phase 3 Ibuprofen/Caffeine Lower Back or Neck Pain Study Completed
  7. Phase 3 The Safety and Efficacy of the Buprenorphine Transdermal System (BTDS) in Subjects With Chronic Back Pain. Completed
  8. Phase 3 Effect of Teriparatide Compared to Risedronate on Back Pain in Women With a Spine Fracture Caused by Osteoporosis Completed
  9. Phase 3 Tapentadol IR vs Oxycodone IR vs Placebo in Acute Pain From Vertebral Compression Fracture Associated With Osteoporosis Completed
  10. Phase 3 NUCYNTA (Tapentadol Immediate Release) Versus Oxycodone Immediate Release in the Treatment of Acute Low Back Pain Completed
  11. Phase 3 An Implantable Spinal Cord Stimulation Pain Management System Completed
  12. Phase 2 Tolperisone in Acute Muscle Spasm of the Back Completed
  13. Phase 2 Safety and Efficacy of XT-150 for Facet Joint Osteoarthritis Pain Completed
  14. Phase 2 Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments Completed
  15. Phase 2 Efficacy of Antidepressants in Chronic Back Pain Completed
  16. Phase 2 An Efficacy and Safety Study for Tapentadol Extended Release (JNS024ER) in Chronic Pain Participants Completed
  17. N/A Strategies for Prescribing Analgesics Comparative Effectiveness Trial Completed
  18. N/A Upright Back Posture Device Study Completed
  19. N/A Rehabilitation in Primary Care: A Project to Maximize the Health Status of Adults With Chronic Illness Completed
  20. N/A Electrical Stimulation for the Treatment of Back Pain Using Peripheral Nerve Stimulation (PNS) Completed
  21. N/A Group-based Mindfulness for Chronic Pain in the Primary Care Setting Completed
  22. N/A Value of Multiple Modalities Using the Spectra WaveWriter Spinal Cord Stimulator System Completed
  23. N/A Spine Pain INtervention to Enhance Care Quality And Reduce Expenditure Completed
  24. N/A Safety and Efficacy Study of the Evoke™ SCS System With Feedback vs. Conventional Stimulation Completed
  25. N/A Patient-Centered Pain Care Using Artificial Intelligence and Mobile Health Tools Completed
  26. N/A ECAP-controlled, Closed-loop Stimulation to Treat Chronic Trunk and/or Limb Pain (ECAP) Completed
  27. N/A Access to a Sit-stand Computer Workstation and Back Pain Completed
  28. N/A Veterans Walk to Beat Back Pain Completed
  29. N/A Virtual Reality Treatment for Adults With Chronic Back Pain Completed
  30. N/A Virtual Reality Guided Imagery for Chronic Pain Completed
  31. N/A Evaluation of Conventional and Long Pulse Widths During a Temporary Spinal Cord Stimulation Trial Completed
  32. N/A Trial of Inserting Prevalence Information Into Lumbar Spine Imaging Reports Completed
  33. N/A Ultrasound-Guided Landmark and Epidural Site Pain Completed
  34. N/A BurstDR™ micrOdosing stimuLation in De-novo Patients Completed
  35. N/A Study to Evaluate Automated Intensity Management in Patients Undergoing a BSC SCS Temporary Trial Completed
  36. N/A Hippocampal Stimulation in Chronic Low Back Pain Completed
  37. N/A Supporting Decision Making for Musculoskeletal Preference-Sensitive Care Completed
  38. N/A Assess the Effectiveness of Pulse RadioFrequency in Patients With Chronic Lumbar Radicular Pain Completed
  39. N/A Combining Mechanisms for Better Outcomes (COMBO) Completed
  40. N/A Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain Completed
  41. N/A LifeWalker Upright Walker vs. Conventional Rollator Walker and Predicate Device Completed
  42. N/A Evaluation of Clinical Outcomes of Pulse Widths in Spinal Cord Stimulation Completed
  43. N/A Acupuncture Approaches for Chronic Pain Completed
  44. N/A Ultra-high Frequency (500 KHz) Spinal Cord Stimulation for Treatment of Chronic Back Pain or Lower Limb Pain Completed

Showing the 50 most-cited and recently-updated of 56 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Back Pain: what the trials found

Pharmacological interventions for back pain show varying degrees of efficacy. Optimal Medical Management (OMM) demonstrated a significantly higher proportion of subjects achieving a ≥50% reduction in low back pain intensity compared to the control group (p=0.036), with significant improvements in both low back pain and leg pain intensity on the Numeric Pain Rating Scale (p<0.001). Oxycodone/Naloxone was associated with a statistically significant reduction in average daily pain scores at week 12 (p=0.002).

Opioid and non-opioid medications showed mixed results in specific metrics. Buprenorphine transdermal patch resulted in significant reductions in 'Pain on the Average' and 'Pain Right Now' scores between days 21-84 (p<0.05). Preservative-free morphine sulfate (PFMS) showed a significant reduction in Visual Analog Scale (VAS) pain intensity at 6 months (p<0.001). In contrast, NUCYNTA did not show a statistically significant difference in Sum of Pain Intensity Difference (SPID) for low back pain at any measured interval (p>0.05).

Neuromodulation and surgical interventions provided varied outcomes. Precision SCS was associated with a 35-point reduction in VAS score at 2 weeks post-fitting. However, the DIAM Spinal Stabilization System did not show a statistically significant difference in the relief of back pain or the reduction of disability compared to the control group (p>0.05).

Other pharmacological agents showed specific effects: Duloxetine was associated with a reduction in MADRS scores and McGill Pain Questionnaire scores. Ibuprofen showed a statistically significant improvement in global assessment of efficacy by the patient at the end of treatment (p=0.0045), though it did not significantly change pain on movement or pressure algometry. Cyclobenzaprine HCl showed a statistically significant difference in physician clinical global assessment on day 3 (p=0.0393).

Recent results — preliminary, needs further review

  • The STEPPT Pilot was associated with an Involvement Rating Score of 8.
  • A 5% lidocaine/5 mg/ml 0.02% estradiol compound cream showed no significant difference in pain scores during the Tampon Test or change in SF-MPQ scores, but was associated with a statistically significant improvement in self-reported physical health via the SF-12 survey (p<0.0001).

For the clinician treating this condition

  • Optimal Medical Management (OMM) is associated with significant reductions in both low back pain and leg pain intensity compared to standard controls.
  • Buprenorphine transdermal patches and preservative-free morphine sulfate (PFMS) demonstrated statistically significant improvements in pain intensity scores.
  • While some interventions like Precision SCS show significant VAS reductions, others like the DIAM Spinal Stabilization System did not reach statistical significance for pain relief or disability reduction.

AI synthesis of 0 cited trials, updated Sep 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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