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Home › Conditions › Contraception

Contraception

0 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Contraception

149 trials tracked for Contraception: 65 in phase 3 or 4 and 19 with published results. The most-cited published study has 528 citations.

149Trials tracked
65Phase 3 & 4
0Recruiting
19With published results
Phase distribution
Phase 4 32 Phase 3 33 Phase 2 10 Phase 1 13 Other / NA 61
  1. Phase 3 Safety and Efficacy of CDB-2914 in Comparison to Levonorgestrel for Emergency Contraception Completed · 528 cited
  2. Phase 4 RAPID EC - Rct Assessing Pregnancy With Intrauterine Devices for EC Completed · 129 cited
  3. Phase 4 Emergency Contraception and Body Weight: Pilot Study Completed · 75 cited
  4. Phase 3 Study of the Safety, Efficacy and Cycle Control of a Contraceptive Vaginal Ring Completed · 67 cited
  5. Phase 3 Contraceptive Effectiveness and Safety of the SILCS Diaphragm Completed · 45 cited
  6. Phase 4 Long-Acting Reversible Contraception Completed · 36 cited
Show 44 more trials
  1. Phase 3 Safety, Efficacy, Tolerability and Pharmacokinetics of LF111 (Drospirenone 4.0 mg) During 13 Cycles Completed · 32 cited
  2. Phase 3 Study to Evaluate the Contraceptive Efficacy/Safety of a Low Dose EE/LNG Transdermal Contraceptive Delivery System Completed · 25 cited
  3. Phase 3 Intervention to End Recurrent Unscheduled Bleeding Trial Completed · 22 cited
  4. Phase 4 Synthetic vs Natural Estrogen in Combined Oral Contraception Completed · 20 cited
  5. Phase 4 LNG-IUS at 2 Weeks Postpartum Completed · 15 cited
  6. Phase 3 Sayana® Press Extension Study Completed · 15 cited
  7. Phase 4 Regulation of Cervical Mucus Secretion Completed · 12 cited
  8. Phase 3 Study of the Safety and Contraceptive Efficacy of Relugolix Combination Therapy in Women With Uterine Fibroids or Endometriosis Who Are at Risk for Pregnancy Completed · 11 cited
  9. Phase 3 E4 FREEDOM (Female Response Concerning Efficacy and Safety of Estetrol/Drospirenone as Oral Contraceptive in a Multicentric Study) - United States/Canada Study Completed · 8 cited
  10. Phase 3 E4 FREEDOM (Female Response Concerning Efficacy and Safety of Estetrol/Drospirenone as Oral Contraceptive in a Multicentric Study) - EU/Russia Study Completed · 8 cited
  11. Phase 4 Nexplanon and Combined Oral Contraceptive (COC) Combined Use Study Completed · 6 cited
  12. Phase 4 BLIS - Breastfeeding Levonorgestrel IUD Study Completed · 2 cited
  13. Phase 4 Desogestrel-containing COCP Pharmacokinetic Validation Study Completed
  14. Phase 4 Postpartum Etonogestrel Implant for Adolescents Completed
  15. Phase 4 EC PK in Women With Normal and Obese BMI Completed
  16. Phase 4 Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding, Contraceptive Continuation, and Depression Completed
  17. Phase 4 Oral Ketorolac for Pain Relief During IUD Insertion Completed
  18. Phase 4 Impact of Combined Hormonal Contraceptives on UPA Completed
  19. Phase 4 Depo Provera Self-Administration Study: Putting a Patient-Centered Practice to the Test at Planned Parenthood Completed
  20. Phase 4 Sayana Press UK Self-Injection Study Completed
  21. Phase 4 Impact of Hormonal Contraception on HIV Acquisition and Transmission Risk Completed
  22. Phase 4 Rifampin and the Contraceptive Implant Completed
  23. Phase 4 Shoulder Contraceptive Implant Study Completed
  24. Phase 4 Effectiveness of Orally Dosed Emergency Contraception in Obese Women - UPA Completed
  25. Phase 4 Progestin-Only Pill Use and Breastfeeding Study Completed
  26. Phase 4 Metabolism of 0.35mg Norethindrone vs 5mg Norethindrone Acetate Completed
  27. Phase 4 Evaluation of Pharmacokinetic Drug-drug Interactions Between Hormonal Contraceptives and Doravirine-containing ART Among Women Living With HIV in South Africa Completed
  28. Phase 4 Breastfeeding Etonogestrel Implant Study Completed
  29. Phase 4 Intrauterine Contraceptive Device (IUD) Placement at Time of C-Section Completed
  30. Phase 4 A Trial in Healthy Female Subjects to Compare the Pharmacokinetics of Ethinyl Estradiol of NuvaRing®, a Contraceptive Patch (EVRA(TM)) and an Oral Contraceptive (Microgynon® 30) (Study 34237 (P06650)) (COMPLETED) Completed
  31. Phase 4 Study of the Use of a Contraceptive Vaginal Ring (NuvaRing) in Normal Daily Practice in Indian Women (P07733) Completed
  32. Phase 4 Immediate Versus Delayed Insertion of the Copper Intrauterine Device (IUD) After Medication Abortion Completed
  33. Phase 4 Effects of St. John's Wort on the Oral Contraceptive Hormone Levonorgestrel Completed
  34. Phase 4 Maintaining Intrauterine Devices (IUDs) in Teens (MINT): A Randomization Trial Completed
  35. Phase 4 Study to Evaluate Cycle Control With Norgestimate/Ethinyl Estradiol and Drospirenone/Ethinyl Estradiol in Healthy Sexually Active Females Completed
  36. Phase 4 Women With Epilepsy: a Pilot Study of PK and PD Anti-epileptic Drug Effects in Levonorgestrel Intrauterine System Users Completed
  37. Phase 3 Transdermal Contraceptive Delivery System (TCDS), Also Known as AG200-15 Patch Arm Completed
  38. Phase 3 AMP002 Phase III Contraceptive Study Completed
  39. Phase 3 Study of Contraceptive Efficacy & Safety of Phexxi™ (Previously Known as Amphora) Gel Compared to Conceptrol Vaginal Gel Completed
  40. Phase 3 Mirena Extension Trial Completed
  41. Phase 3 Efficacy and Safety of Two Flexible Extended Regimens of BAY86-5300 (SH T00186D) in Comparison With the Conventional Regimen of YAZ Completed
  42. Phase 3 A Multicenter Trial to Evaluate the Insertion Characteristics of the Radiopaque Etonogestrel Implant Using a Next Generation Applicator (34530)(P05702) Completed
  43. Phase 3 A Study to Evaluate the Efficacy and Safety of DR-102 for the Prevention of Pregnancy Completed
  44. Phase 3 To Compare SH T00658ID Over Ortho Tri-Cyclen Lo (US/Canada) Completed

Showing the 50 most-cited and recently-updated of 149 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Contraception: what the trials found

New clinical evidence demonstrates that a combination of 150 mg Nestorone and 15 mg ethinyl estradiol (150/15 NES/EE CVR) resulted in a Pearl Index of 3.92 for subjects aged 35 or younger 1. This regimen was associated with consistent bleeding patterns, specifically between 4.3 and 4.6 scheduled bleeding days and 0.7 to 1.3 unscheduled bleeding days 1.

Other established methods include the Copper IUD, which showed pregnancy rates of 0% and 0.3% 7, and the Levonorgestrel IUD, which was associated with breastfeeding continuation rates of 86% to 88% at 8 weeks postpartum 14. The Etonogestrel implant is supported by data regarding consistent hormonal contraceptive concentrations 17 and high levels of satisfaction with postpartum contraception counseling 15.

Additional established methods include DMPA 9, the Levonorgestrel Intrauterine System (LNG-IUS) 11, Desogestrel and Ethinyl Estradiol tablets 16, Norethindrone Acetate 5 MG 18, and the Etonog_estrel implant 21. UPA-ECx1 was shown to delay follicular rupture by more than 5 days in a majority of participants 20.

Recent results — preliminary, needs further review

  • * LevoCept showed a cumulative pregnancy percentage of 0% across study arms, with varying bleeding/spotting patterns 3. * A levonorgestrel patch was evaluated in patients with a BMI between 32 and 40 kg/m²; results indicated that while some subjects had poor cervical mucus scores, several still showed evidence of potential or likely ovulation 4. * The Woman's Condom demonstrated low rates of clinical breakage (1.2%), misdirection (2.2%), and slippage (4.3%) 6.

For the clinician treating this condition

  • The 150/15 NES/EE CVR combination provides a documented Pearl Index of 3.92 for women aged 35 or younger 1.
  • Long-acting methods like the Copper IUD and Levonorgestrel IUD are established options with high breastfeeding continuation rates [7, 14].
  • The Etonogestrel implant maintains consistent hormonal concentrations in clinical use 17.

AI synthesis of 14 cited trials, updated Jun 22, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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